SMURF2 and ING2

Number of citations of the paper that reports this interaction (PMID 15761153)
154

Data Source:
HPRD (in vivo)

		SMURF2	ING2
Gene Name		SMAD specific E3 ubiquitin protein ligase 2	inhibitor of growth family, member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Raft	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Sin3 Complex CCAAT-binding Factor Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Ligase Activity Identical Protein Binding SMAD Binding	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Protein Complex Binding Methylated Histone Binding Phosphatidylinositol Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Canonical Wnt Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Male Meiosis I Signal Transduction Spermatogenesis Spermatid Development Negative Regulation Of Cell Proliferation Chromatin Modification Sperm Motility Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Male Germ-line Stem Cell Asymmetric Division Seminiferous Tubule Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Cellular Senescence Regulation Of Response To DNA Damage Stimulus
Pathways		Loss of Function of TGFBR2 in Cancer Antigen processing: Ubiquitination & Proteasome degradation Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs Signaling by Wnt Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by BMP Generic Transcription Pathway RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Class I MHC mediated antigen processing & presentation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer TCF dependent signaling in response to WNT Asymmetric localization of PCP proteins Signaling by Hedgehog degradation of AXIN Signaling by WNT in cancer PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		79 interactors: ACBD3 ACOX3 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CUEDC1 DAB2 DAZAP2 DGCR2 EGFR EPHA1 FAM175B FKBP4 FLNB GNG2 HDGFRP3 ING2 IRF3 IRF8 KLF5 LAPTM5 LATS1 MAVS NEK6 NKIRAS1 NRAS PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOA RHOD RLIM RNF11 RNF111 RNF2 RNF20 RPS27A RRAS2 RUNX2 RUNX3 SF3A2 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNRNP70 SOCS6 SPG20 SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TRAF2 TRAF4 TSSK4 TXNIP UBC UBE2D1 UBE2D3 UBE2L3 YY1 ZBTB44	9 interactors: APP COPS2 EP300 HIST3H3 HIST4H4 SMAD1 SMURF1 SMURF2 SUMO1
Entrez ID		64750	3622
HPRD ID		06901	05021
Ensembl ID			ENSG00000168556
Uniprot IDs		Q96DE7 Q9HAU4	Q9H160
PDB IDs		1ZVD 2DJY 2JQZ 2KXQ 2LTZ
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Organic Substance Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Signal Transduction Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cell Communication Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Signaling Protein Polyubiquitination Response To Stimulus Epithelium Development Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Ubiquitination Regulation Of Protein Metabolic Process Multicellular Organismal Development Tissue Development Protein Modification By Small Protein Conjugation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Organ Development Regulation Of RNA Metabolic Process Anatomical Structure Development	Cellular Protein Modification Process Negative Regulation Of Gene Expression Ubiquitin-dependent SMAD Protein Catabolic Process BMP Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Binding Striated Muscle Tissue Development Muscle Tissue Development Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Telomere Maintenance Histone H2B Acetylation Cellular Metabolic Process Gene Expression Posttranscriptional Regulation Of Gene Expression Signal Transduction Regulation Of Metabolic Process Gene Silencing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Synaptic Growth At Neuromuscular Junction Signaling Defense Response Cellular Response To Growth Factor Stimulus
Tagcloud ?		autoinhibitory biochemical c2 catalytic controlled domain dysregulation e3 e3s framework hect impaired interaction intramolecular ligases magnetic maintaining nedd4 nmr noncovalent regulate regulators resonance state structural terminal transthiolation ub ubiquitin	acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a e3 ing1 ing1b ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic pias4 preferred reveals s199d stoichiometric sumo sumoylation suppressors
Tagcloud (Difference) ?		autoinhibitory biochemical c2 catalytic controlled domain dysregulation e3s framework hect impaired interaction intramolecular ligases magnetic maintaining nedd4 nmr noncovalent regulate regulators resonance state structural terminal transthiolation ub ubiquitin	acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a ing1 ing1b ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic pias4 preferred reveals s199d stoichiometric sumo sumoylation suppressors
Tagcloud (Intersection) ?		e3