SMURF2 and ARHGAP5

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		SMURF2	ARHGAP5
Description		SMAD specific E3 ubiquitin protein ligase 2	Rho GTPase activating protein 5
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Membrane Raft	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Identical Protein Binding SMAD Binding Ubiquitin Protein Ligase Activity	GTPase Activity GTPase Activator Activity Protein Binding SH2 Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Trophoblast Cell Migration	Positive Regulation Of Mesenchymal Cell Proliferation Cell Adhesion Signal Transduction Rho Protein Signal Transduction Regulation Of Cell Size Epithelial Cell Migration Positive Regulation Of Epithelial Cell Migration Cell Migration Mammary Gland Development Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Asymmetric localization of PCP proteins Degradation of AXIN Hedgehog 'on' state Hedgehog 'on' state Ub-specific processing proteases Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Cardiac troponin-I levels ( 31014085) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Periodontitis (Mean PAL) ( 24024966)	Asthma ( 29273806)
Interacting Genes		94 interacting genes: ABRAXAS2 ACBD3 ACOX3 ADAR AIMP2 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CNKSR2 CUEDC1 DAB2 DAZAP2 DGCR2 DSCR9 EGFR EPHA1 ERBB2 FKBP4 FLNB FUBP1 GNG2 HDGFL3 ING2 IRF3 IRF8 ITGB1BP1 KLF5 LAPTM5 LATS1 LITATS1 LMNA MAVS NEK6 NKIRAS1 NRAS PARP1 PDE4B PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOD RLIM RNF11 RNF111 RNF2 RPS27A RRAS2 RTN4IP1 RUNX2 RUNX3 SF3A2 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNCA SNRNP70 SOCS6 SPART SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TOP2A TRAF2 TRAF4 TRIM28 TSSK4 TXNIP UBC UBE2D2 UBE2D3 UBE2L3 USP15 XPO1 YY1 ZBTB44	12 interacting genes: ADRB2 CSDE1 FGF13 HSPA13 ITGA5 ITGB1 PTK2B PTPN18 RASA1 RHOA RND3 SMURF2
Entrez ID		64750	394
HPRD ID		06901	04060
Ensembl ID		ENSG00000108854	ENSG00000100852
Uniprot IDs		Q96DE7 Q9HAU4	Q13017
PDB IDs		1ZVD 2DJY 2JQZ 2KXQ 2LTZ 6FX4 7M3Q	2EE4 2EE5 5U4V
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding I-SMAD Binding Heteromeric SMAD Protein Complex Response To Growth Factor Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Protein-containing Complex Negative Regulation Of RNA Metabolic Process GTPase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process GDP Binding Negative Regulation Of Transcription By RNA Polymerase II GTP Binding Nucleoplasm Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytosol Negative Regulation Of Signal Transduction SMAD Protein Complex Cell Surface Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Cell Development Regulation Of RNA Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Transcription Regulator Complex Ureteric Bud Development Negative Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Response To Transforming Growth Factor Beta Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Osteoblast Fate Commitment Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Mesonephric Tubule Development Cellular Developmental Process Intracellular Signal Transduction Mesonephric Epithelium Development Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process R-SMAD Binding	Integrin Alpha5-beta1 Complex Wound Healing, Spreading Of Cells Regulation Of Developmental Process Focal Adhesion Cell-cell Adhesion Mediated By Integrin Anatomical Structure Formation Involved In Morphogenesis Plasma Membrane Regulation Of Cell-substrate Adhesion CD40 Signaling Pathway Regulation Of Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Ruffle Membrane Integrin-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Cell-matrix Adhesion Angiogenesis Ruffle Cell Differentiation Negative Regulation Of Anoikis Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-matrix Adhesion Signal Transduction Regulation Of Organelle Organization Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Bone Resorption Blood Vessel Diameter Maintenance Regulation Of Tube Size Cell-substrate Adhesion Regulation Of Supramolecular Fiber Organization Neuron Migration Regulation Of Actin Filament-based Process Regulation Of Anoikis Integrin Complex Cell Adhesion Mediated By Integrin LncRNA Binding Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Developmental Process Cerebral Cortex Cell Migration Response To Muscle Activity Positive Regulation Of Excitatory Postsynaptic Potential Cell Surface Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Angiogenesis
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