SMURF2 and ARHGAP5

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SMURF2	ARHGAP5
Gene Name		SMAD specific E3 ubiquitin protein ligase 2	Rho GTPase activating protein 5
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Raft	Cytoplasm Cytosol Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Ligase Activity Identical Protein Binding SMAD Binding	GTPase Activity Rho GTPase Activator Activity Protein Binding GTP Binding SH2 Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Canonical Wnt Signaling Pathway	Positive Regulation Of Mesenchymal Cell Proliferation Cell Adhesion Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Metabolic Process Regulation Of Cell Size Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of Rho GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Loss of Function of TGFBR2 in Cancer Antigen processing: Ubiquitination & Proteasome degradation Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs Signaling by Wnt Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by BMP Generic Transcription Pathway RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Class I MHC mediated antigen processing & presentation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer TCF dependent signaling in response to WNT Asymmetric localization of PCP proteins Signaling by Hedgehog degradation of AXIN Signaling by WNT in cancer PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System	Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS
Protein-Protein Interactions		79 interactors: ACBD3 ACOX3 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CUEDC1 DAB2 DAZAP2 DGCR2 EGFR EPHA1 FAM175B FKBP4 FLNB GNG2 HDGFRP3 ING2 IRF3 IRF8 KLF5 LAPTM5 LATS1 MAVS NEK6 NKIRAS1 NRAS PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOA RHOD RLIM RNF11 RNF111 RNF2 RNF20 RPS27A RRAS2 RUNX2 RUNX3 SF3A2 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNRNP70 SOCS6 SPG20 SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TRAF2 TRAF4 TSSK4 TXNIP UBC UBE2D1 UBE2D3 UBE2L3 YY1 ZBTB44	11 interactors: ADRB2 ITGA5 ITGB1 PTK2B PTPN18 RASA1 RHOA RND1 RND2 RND3 SMURF2
Entrez ID		64750	394
HPRD ID		06901	04060
Ensembl ID			ENSG00000100852
Uniprot IDs		Q96DE7 Q9HAU4	Q13017
PDB IDs		1ZVD 2DJY 2JQZ 2KXQ 2LTZ	2EE4 2EE5
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Organic Substance Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Signal Transduction Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cell Communication Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Signaling Protein Polyubiquitination Response To Stimulus Epithelium Development Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Ubiquitination Regulation Of Protein Metabolic Process Multicellular Organismal Development Tissue Development Protein Modification By Small Protein Conjugation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Organ Development Regulation Of RNA Metabolic Process Anatomical Structure Development	Axon Guidance Neuron Projection Development Regulation Of Cell-substrate Adhesion Cell Junction Assembly Generation Of Neurons Neuron Development Neurogenesis Axonogenesis Positive Regulation Of Neuron Projection Development Signal Transduction Axon Development Cell Morphogenesis Involved In Neuron Differentiation Response To External Stimulus Actin Cytoskeleton Organization Neuron Differentiation Chemotaxis Cell-cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Cell Projection Organization Signaling Positive Regulation Of Cell Projection Organization Neuron Projection Morphogenesis Actin Filament-based Process Cell Communication Locomotion Positive Regulation Of Signal Transduction Cell Morphogenesis Involved In Differentiation Positive Regulation Of Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Adhesion Mediated By Integrin Positive Regulation Of Cell-substrate Adhesion Nervous System Development Integrin-mediated Signaling Pathway Regulation Of Neuron Projection Development Cell Differentiation Movement Of Cell Or Subcellular Component Negative Regulation Of Anoikis Cell Projection Morphogenesis Cellular Response To Stimulus Cell Part Morphogenesis Positive Regulation Of Neurogenesis Blood Vessel Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Anoikis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Morphogenesis Blood Vessel Endothelial Cell Migration Heterotypic Cell-cell Adhesion Regulation Of Cell Projection Organization Positive Regulation Of Cell Development
Tagcloud ?		autoinhibitory biochemical c2 catalytic controlled domain dysregulation e3 e3s framework hect impaired interaction intramolecular ligases magnetic maintaining nedd4 nmr noncovalent regulate regulators resonance state structural terminal transthiolation ub ubiquitin	10a 200c 30a 30c cd36 cdh2 cdk5r1 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Difference) ?		autoinhibitory biochemical c2 catalytic controlled domain dysregulation e3 e3s framework hect impaired interaction intramolecular ligases magnetic maintaining nedd4 nmr noncovalent regulate regulators resonance state structural terminal transthiolation ub ubiquitin	10a 200c 30a 30c cd36 cdh2 cdk5r1 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Intersection) ?