MAP3K13 and HLA-DRB3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MAP3K13	HLA-DRB3
Gene Name		mitogen-activated protein kinase kinase kinase 13	major histocompatibility complex, class II, DR beta 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	IkappaB Kinase Complex Membrane	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Protein Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Activation Of MAPKK Activity Protein Phosphorylation JNK Cascade Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity	Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Inflammatory Response To Antigenic Stimulus Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response Signal Transduction Detection Of Bacterium Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Regulation Of Interleukin-4 Production Negative Regulation Of Interferon-gamma Production Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T-helper 1 Type Immune Response Negative Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Protein Tetramerization Interferon-gamma-mediated Signaling Pathway Regulation Of Interleukin-10 Secretion
Pathways			Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Airflow obstruction ( 22837378)
Protein-Protein Interactions		7 interactors: GLO1 HLA-DRB3 IKBKB MAP2K7 MAPK8IP1 PRDX3 STAT3	4 interactors: CDCA8 CTAG1B MAP3K13 POMC
Entrez ID		9175	3125
HPRD ID		05372	09985
Ensembl ID		ENSG00000073803
Uniprot IDs		O43283	P79483
PDB IDs			2Q6W 3C5J 4H1L
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Death Negative Regulation Of Cell Death Regulation Of Apoptotic Process Response To Cytokine Response To Stress Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Immune System Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Organic Substance Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of JUN Kinase Activity JNK Cascade Defense Response Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Peptidyl-cysteine Oxidation Response To Tumor Necrosis Factor Positive Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Antigen Receptor-mediated Signaling Pathway Activation Of Innate Immune Response Regulation Of JNK Cascade Phosphorylation Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Sorbitol Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Stress-activated MAPK Cascade Intracellular Receptor Signaling Pathway Regulation Of Immune Response
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