MAP3K13

Description		mitogen-activated protein kinase kinase kinase 13
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding IkappaB Kinase Complex Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation JNK Cascade Positive Regulation Of Neuron Maturation Intracellular Signal Transduction Positive Regulation Of Axon Extension Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Branching Morphogenesis Of A Nerve
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Airflow obstruction ( 22837378) Arterial stiffness index ( 31235810) Major depressive disorder ( 27519822) Neonatal white matter microstructure ( 33009551)
Novel Interacting Genes		1 novel interacting genes: CD44
Interacting Genes		8 interacting genes: GLO1 HLA-DRB3 IKBKB MAP2K7 MAPK8IP1 PRDX3 STAT3 TRIM25
Entrez ID		9175
HPRD ID		05372
Ensembl ID		ENSG00000073803
Uniprot IDs		O43283
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Cellular Response To Cytokine Stimulus Fc-epsilon Receptor Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Stress-activated MAPK Cascade Negative Regulation Of Phosphate Metabolic Process Response To Cytokine Response To Peptide Regulation Of Intracellular Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Receptor Signaling Pathway MAPK Cascade Negative Regulation Of Cytokine Production Involved In Inflammatory Response Antigen Processing And Presentation Of Exogenous Antigen Regulation Of RNA Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction JNK Cascade MRNA Transcription Lactoylglutathione Lyase Activity Antigen Processing And Presentation Of Peptide Antigen Regulation Of Canonical NF-kappaB Signal Transduction Response To Lipid Dentate Gyrus Mossy Fiber NADH-dependent Peroxiredoxin Activity Regulation Of Nucleobase-containing Compound Metabolic Process Cytosol Negative Regulation Of Apoptotic Process Intracellular Signaling Cassette Immune Response-activating Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytokine Production Involved In Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Monocyte Aggregation
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