ARHGEF1 and CSNK1E

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ARHGEF1	CSNK1E
Gene Name		Rho guanine nucleotide exchange factor (GEF) 1	casein kinase 1, epsilon
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Nucleus Cytoplasm Cytosol Ribonucleoprotein Complex
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Poly(A) RNA Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Rho Protein Signal Transduction Cell Proliferation Positive Regulation Of Rho GTPase Activity Termination Of G-protein Coupled Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Axonogenesis Negative Regulation Of Axonogenesis	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Repair Protein Phosphorylation Endocytosis Organelle Organization Signal Transduction Circadian Rhythm Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Cellular Protein Localization Regulation Of Circadian Rhythm Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Signaling by GPCR GPCR downstream signaling Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis G alpha (12/13) signalling events p75 NTR receptor-mediated signalling	Organelle biogenesis and maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling G2/M Transition Assembly of the primary cilium Signaling by Wnt Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic WNT mediated activation of DVL Loss of proteins required for interphase microtubule organizationÂ from the centrosome TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Loss of Nlp from mitotic centrosomes XAV939 inhibits tankyrase, stabilizing AXIN Centrosome maturation Signaling by WNT in cancer Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ATR CD44 CNKSR1 CSNK1E GNA13 HRAS PRKCA RAP1A RHOA SREBF2 TCF4	40 interactors: AKAP9 ANKRD6 APC APP ARHGEF1 ARNTL AXIN1 AXIN2 BBS10 BID C2orf44 CADM4 CRY1 DVL1 DVL2 DVL3 FAM110A FAM110C FAM83D FBP1 GTF3C1 HES1 KAT7 MCC NCOA3 PER1 PER2 PER3 PNO1 PPP1CA PPP1R14A RAD54B RBX1 SDCCAG3 SOCS3 TAOK1 TAZ TNS2 ZMYND8 ZNF227
Entrez ID		9138	1454
HPRD ID		03511	02919
Ensembl ID		ENSG00000076928	ENSG00000213923
Uniprot IDs		Q6NX52 Q92888	B0QY34 P49674 Q5U045
PDB IDs		1IAP 1SHZ 3AB3 3ODO 3ODW 3ODX 3P6A	4HNI 4HOK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Positive Regulation Of Intracellular Signal Transduction Ras Protein Signal Transduction Response To Stress Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of ERK1 And ERK2 Cascade Response To Wounding Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of ERK1 And ERK2 Cascade Platelet Activation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Rho Protein Signal Transduction Signal Transduction Cell Cycle Process Tissue Development Regulation Of Intracellular Signal Transduction Epithelium Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Small GTPase Mediated Signal Transduction Signaling Cell Communication Positive Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Regulation Of Signaling Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Cycle Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Peptidyl-serine Phosphorylation Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Energy Reserve Metabolic Process Tube Morphogenesis Response To Organic Substance Positive Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Morphogenesis Morphogenesis Of An Epithelium Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus	Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Regulation Of Wnt Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Regulation Of Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Phosphorus Metabolic Process Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Intracellular Signal Transduction Wnt Signaling Pathway Signaling Regulation Of JNK Cascade Circadian Rhythm Cell Communication Canonical Wnt Signaling Pathway Regulation Of Stress-activated MAPK Cascade Planar Cell Polarity Pathway Involved In Neural Tube Closure Cochlea Development Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Positive Regulation Of JNK Cascade Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Regulation Of Epithelial Cell Differentiation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Kinase Activity Regulation Of Cell Differentiation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stimulus Wnt Signaling Pathway, Planar Cell Polarity Pathway Epithelium Development Positive Regulation Of Metabolic Process Entrainment Of Circadian Clock By Photoperiod
Tagcloud ?		activates angiotensin arterial arteries causative elusive environmental exchange feature frequent guanine hypertension ii inactivation industrialized monomeric muscle pathologies phosphorylates recognized remains responsible rhoa smooth specifically tyr738 unclear undescribed world	accessible applicable cancerous chosen constitute crc ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs polb ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a
Tagcloud (Difference) ?		activates angiotensin arterial arteries causative elusive environmental exchange feature frequent guanine hypertension ii inactivation industrialized monomeric muscle pathologies phosphorylates recognized remains responsible rhoa smooth specifically tyr738 unclear undescribed world	accessible applicable cancerous chosen constitute crc ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs polb ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a
Tagcloud (Intersection) ?