ARHGEF1 and RAP1A

Number of citations of the paper that reports this interaction (PubMedID 12581858)
0

Data Source:
BioGRID (enzymatic study)

		ARHGEF1	RAP1A
Description		Rho guanine nucleotide exchange factor 1	RAP1A, member of RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Cytoplasm Endosome Early Endosome Late Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Specific Granule Membrane Neuron Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Sperm Midpiece Presynapse Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Binding RNA Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Nucleotide Binding GTPase Activity G Protein Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Small GTPase Binding Protein-containing Complex Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway	Signal Transduction Small GTPase-mediated Signal Transduction Nervous System Development Response To Carbohydrate Positive Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Rap Protein Signal Transduction Negative Regulation Of Collagen Biosynthetic Process Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of D-glucose Import Positive Regulation Of Phagocytosis Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Protein Localization To Plasma Membrane Response To Antineoplastic Agent Liver Regeneration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Cell Junction Assembly Cellular Response To Forskolin Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Hallux valgus ( 32131869)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 30500874 32581322) High altitude adaptation ( 28373541) Lymphocyte count ( 32888494) Osteoporosis-related phenotypes ( 20548944)
Interacting Genes		12 interacting genes: ATR CD44 CNKSR1 CSNK1E GNA13 HRAS PRKCA RAP1A RHOA RNF10 SREBF2 TCF4	43 interacting genes: AFDN APBB1IP ARHGEF1 BIN1 BMX BRAF ELOA FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A HSPA4 KRIT1 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALGDS RAP1GAP RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA2 SMARCA4 TNFRSF10C
Entrez ID		9138	5906
HPRD ID		03511	01545
Ensembl ID		ENSG00000076928	ENSG00000116473
Uniprot IDs		M0QZR4 Q92888	A8KAH9 P62834
PDB IDs		1IAP 1SHZ 3AB3 3ODO 3ODW 3ODX 3P6A	1C1Y 1GUA 3KUC 4KVG
Enriched GO Terms of Interacting Partners?		G Protein Activity Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Junction Assembly Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Nucleotide Binding Positive Regulation Of Signal Transduction GTPase Activity Regulation Of Cell Communication Regulation Of Signaling Membrane Disassembly Nuclear Membrane Disassembly Regulation Of ERK1 And ERK2 Cascade Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane GTP Binding Intracellular Signaling Cassette Wound Healing, Spreading Of Cells Cellular Response To Gamma Radiation Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Positive Regulation Of MAPK Cascade Regulation Of Protein Localization Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Component Biogenesis Cellular Response To Nerve Growth Factor Stimulus Regulation Of Developmental Process Glutamatergic Synapse Response To Nerve Growth Factor Regulation Of Cellular Component Organization Nuclear Membrane Organization Non-canonical Wnt Signaling Pathway Response To Gamma Radiation Positive Regulation Of Cellular Component Organization Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation E-box Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of MAPK Cascade Cellular Response To Growth Factor Stimulus Regulation Of Cell Projection Organization Positive Regulation Of MiRNA Metabolic Process Rho Protein Signal Transduction	GTPase Regulator Activity Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction Guanyl-nucleotide Exchange Factor Activity Signal Transduction Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of GTPase Activity Plasma Membrane Establishment Of Endothelial Barrier Endothelial Cell Development Positive Regulation Of GTPase Activity CD95 Death-inducing Signaling Complex Positive Regulation Of Hydrolase Activity Neurotrophin Signaling Pathway Epithelial Cell Development Rap Protein Signal Transduction Regulation Of Microvillus Assembly GTPase Binding Regulation Of Signal Transduction Regulation Of Apoptotic Process Cytosol Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Communication Regulation Of Signaling Small GTPase Binding Nerve Growth Factor Signaling Pathway Establishment Of Endothelial Intestinal Barrier Death-inducing Signaling Complex Assembly Diacylglycerol Binding Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling CAMP Binding Fas Signaling Pathway Protein-containing Complex Organization Cytoplasm Positive Regulation Of Cellular Component Biogenesis Regulation Of Developmental Process Protein-containing Complex Assembly GTPase Activator Activity Regulation Of Cellular Component Organization Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Nucleosome Array Spacer Activity Positive Regulation Of Microvillus Assembly Regulation Of Cell Differentiation
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