ARHGEF1

Description		Rho guanine nucleotide exchange factor 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Binding RNA Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Hallux valgus ( 32131869)
Interacting Genes		12 interacting genes: ATR CD44 CNKSR1 CSNK1E GNA13 HRAS PRKCA RAP1A RHOA RNF10 SREBF2 TCF4
Entrez ID		9138
HPRD ID		03511
Ensembl ID		ENSG00000076928
Uniprot IDs		M0QZR4 Q92888
PDB IDs		1IAP 1SHZ 3AB3 3ODO 3ODW 3ODX 3P6A
Enriched GO Terms of Interacting Partners?		G Protein Activity Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Junction Assembly Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Nucleotide Binding Positive Regulation Of Signal Transduction GTPase Activity Regulation Of Cell Communication Regulation Of Signaling Membrane Disassembly Nuclear Membrane Disassembly Regulation Of ERK1 And ERK2 Cascade Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane GTP Binding Intracellular Signaling Cassette Wound Healing, Spreading Of Cells Cellular Response To Gamma Radiation Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Positive Regulation Of MAPK Cascade Regulation Of Protein Localization Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Component Biogenesis Cellular Response To Nerve Growth Factor Stimulus Regulation Of Developmental Process Glutamatergic Synapse Response To Nerve Growth Factor Regulation Of Cellular Component Organization Nuclear Membrane Organization Non-canonical Wnt Signaling Pathway Response To Gamma Radiation Positive Regulation Of Cellular Component Organization Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation E-box Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of MAPK Cascade Cellular Response To Growth Factor Stimulus Regulation Of Cell Projection Organization Positive Regulation Of MiRNA Metabolic Process Rho Protein Signal Transduction
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