INPPL1 and FCGR2B

Number of citations of the paper that reports this interaction (PMID 10789675)
9

Data Source:
HPRD (in vivo, in vitro)

		INPPL1	FCGR2B
Gene Name		inositol polyphosphate phosphatase-like 1	Fc fragment of IgG, low affinity IIb, receptor (CD32)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Lamellipodium Filopodium	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Actin Binding Protein Binding Hydrolase Activity SH3 Domain Binding SH2 Domain Binding	Protein Binding IgG Binding
	Biological Process	Endochondral Ossification Immune System Process Glucose Metabolic Process Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Actin Filament Organization Cell Adhesion Negative Regulation Of Cell Proliferation Post-embryonic Development Negative Regulation Of Gene Expression Response To Insulin Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation Ruffle Assembly	Immune Response Signal Transduction Viral Process Regulation Of Immune Response
Pathways		Synthesis of PIPs at the plasma membrane Signaling by Interleukins Interleukin receptor SHC signaling Synthesis of IP3 and IP4 in the cytosol Metabolism of lipids and lipoproteins Interleukin receptor SHC signaling Cytokine Signaling in Immune system Interleukin-2 signaling Phospholipid metabolism Interleukin-3, 5 and GM-CSF signaling Inositol phosphate metabolism PI Metabolism	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Lipid metabolism phenotypes ( 22286219) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		14 interactors: ABL1 BCAR1 CBL CD4 CSF1R EGFR FCGR2B FLNC HID1 MET SHC1 SORBS1 SORBS3 SRC	11 interactors: APCS BLK C14orf1 CRP INPP5D INPPL1 LY6E LYN MAPK1 MAPK3 PTPN6
Entrez ID		3636	2213
HPRD ID		02900	06849
Ensembl ID		ENSG00000165458	ENSG00000072694
Uniprot IDs		O15357	P31994
PDB IDs		2K4P 2KSO 3NR8 4A9C	2FCB
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Transport Cell Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Regulation Of Kinase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Immune Response Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Actin Filament Organization Actin Cytoskeleton Organization Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Signaling Regulation Of Cell Motility Positive Regulation Of Cell Migration Actin Filament-based Process Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Locomotion Regulation Of Locomotion Cell Activation Regulation Of Cellular Component Movement Cell Proliferation Platelet-derived Growth Factor Receptor Signaling Pathway Response To Organic Substance Regulation Of Cellular Amino Acid Metabolic Process	JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Response To Growth Hormone Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Immune Response Regulation Of Immune System Process Response To Peptide Hormone Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Response To Peptide Positive Regulation Of Immune System Process Wound Healing Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Wounding Defense Response Lipopolysaccharide-mediated Signaling Pathway Innate Immune Response Peptidyl-tyrosine Autophosphorylation Response To Organonitrogen Compound Blood Coagulation Hemostasis Regulation Of Golgi Inheritance Cellular Response To Organonitrogen Compound Platelet Activation Response To Hormone Negative Regulation Of Myeloid Leukocyte Differentiation Caveolin-mediated Endocytosis Regulation Of Cellular Localization Cellular Response To Heat Regulation Of Body Fluid Levels Negative Regulation Of Monocyte Differentiation Cellular Response To Hormone Stimulus Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Phagocytosis Regulation Of Golgi Organization Leukocyte Mediated Immunity Negative Regulation Of Leukocyte Proliferation Peptidyl-tyrosine Phosphorylation Endocytosis Response To Insulin Regulation Of MAP Kinase Activity
Tagcloud ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x	arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr3a genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Difference) ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x	arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr3a genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Intersection) ?