INPPL1 and HID1

Number of citations of the paper that reports this interaction (PMID 20368287)
12

Data Source:
BioGRID (two hybrid)

		INPPL1	HID1
Gene Name		inositol polyphosphate phosphatase-like 1	HID1 domain containing
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Lamellipodium Filopodium	Golgi Trans Cisterna Cytoplasm Golgi Apparatus Golgi Medial Cisterna Cytoplasmic Microtubule Extracellular Vesicular Exosome Extrinsic Component Of Golgi Membrane
	Molecular Function	Actin Binding Protein Binding Hydrolase Activity SH3 Domain Binding SH2 Domain Binding	Protein Binding
	Biological Process	Endochondral Ossification Immune System Process Glucose Metabolic Process Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Actin Filament Organization Cell Adhesion Negative Regulation Of Cell Proliferation Post-embryonic Development Negative Regulation Of Gene Expression Response To Insulin Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation Ruffle Assembly	Intracellular Protein Transport Response To Brefeldin A
Pathways		Synthesis of PIPs at the plasma membrane Signaling by Interleukins Interleukin receptor SHC signaling Synthesis of IP3 and IP4 in the cytosol Metabolism of lipids and lipoproteins Interleukin receptor SHC signaling Cytokine Signaling in Immune system Interleukin-2 signaling Phospholipid metabolism Interleukin-3, 5 and GM-CSF signaling Inositol phosphate metabolism PI Metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ABL1 BCAR1 CBL CD4 CSF1R EGFR FCGR2B FLNC HID1 MET SHC1 SORBS1 SORBS3 SRC	7 interactors: BEGAIN CBS CSDE1 INPPL1 RAD51 RBBP8 RCN3
Entrez ID		3636	283987
HPRD ID		02900	05766
Ensembl ID		ENSG00000165458	ENSG00000167861
Uniprot IDs		O15357	Q8IV36
PDB IDs		2K4P 2KSO 3NR8 4A9C
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Transport Cell Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Regulation Of Kinase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Immune Response Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Actin Filament Organization Actin Cytoskeleton Organization Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Signaling Regulation Of Cell Motility Positive Regulation Of Cell Migration Actin Filament-based Process Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Locomotion Regulation Of Locomotion Cell Activation Regulation Of Cellular Component Movement Cell Proliferation Platelet-derived Growth Factor Receptor Signaling Pathway Response To Organic Substance Regulation Of Cellular Amino Acid Metabolic Process	Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cysteine Biosynthetic Process From Serine Homocysteine Catabolic Process Cysteine Biosynthetic Process Via Cystathionine Transsulfuration Double-strand Break Repair Positive Regulation Of DNA Ligation Nuclear-transcribed MRNA Catabolic Process, No-go Decay DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Cysteine Biosynthetic Process L-cysteine Catabolic Process Cellular Response To Camptothecin Hydrogen Sulfide Biosynthetic Process Response To Camptothecin L-serine Catabolic Process Meiotic Cell Cycle DNA Recombinase Assembly Hydrogen Sulfide Metabolic Process DNA Recombination Cysteine Metabolic Process DNA Double-strand Break Processing Homocysteine Metabolic Process Blastocyst Hatching Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Unwinding Involved In DNA Replication Sulfur Amino Acid Catabolic Process Serine Family Amino Acid Catabolic Process Ruffle Assembly Aromatic Compound Catabolic Process Cellular Modified Amino Acid Catabolic Process Sulfur Amino Acid Biosynthetic Process Cellular Metabolic Process Regulation Of Double-strand Break Repair Catabolic Process Mitotic Recombination L-serine Metabolic Process Phosphatidylinositol Dephosphorylation G2 DNA Damage Checkpoint DNA Catabolic Process, Exonucleolytic DNA Repair Ruffle Organization Phospholipid Dephosphorylation Cellular Response To Alkaloid Endochondral Ossification Sulfur Amino Acid Metabolic Process Reciprocal Meiotic Recombination Inositol Phosphate Metabolic Process
Tagcloud ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x
Tagcloud (Difference) ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x
Tagcloud (Intersection) ?