INPPL1 and ARAP3

Number of citations of the paper that reports this interaction (PubMedID 17314030)
0

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		INPPL1	ARAP3
Description		inositol polyphosphate phosphatase like 1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
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GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Basal Plasma Membrane Membrane Nuclear Speck Lamellipodium Filopodium Cell Projection	Ruffle Cytoplasm Cytoskeleton Plasma Membrane Membrane Lamellipodium Cell Projection
	Molecular Function	Actin Binding Inositol-polyphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity SH3 Domain Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity SH2 Domain Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Endochondral Ossification Immune System Process Glucose Metabolic Process Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Apoptotic Process Actin Filament Organization Cell Adhesion Negative Regulation Of Cell Population Proliferation Post-embryonic Development Gene Expression Negative Regulation Of Gene Expression Response To Insulin Regulation Of Protein Localization Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol Dephosphorylation Regulation Of Immune Response ERK1 And ERK2 Cascade Ruffle Assembly Regulation Of Actin Filament Organization	Cytoskeleton Organization Signal Transduction Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling Signaling by CSF1 (M-CSF) in myeloid cells	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Heart rate response to recovery post exercise (10 sec) ( 29497042)	Cerebral amyloid deposition (PET imaging) ( 26252872) Diffuse large B cell lymphoma ( 25261932) Fasting plasma glucose ( 32682390) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Household income ( 31844048) Lung cancer ( 28604730) Mean arterial pressure ( 27618448) Offspring birth weight ( 31043758)
Interacting Genes		23 interacting genes: ABL1 AR ARAP3 BCAR1 CBL CD4 CSF1R EGFR ERBB2 ERBB3 ERBB4 FCGR2B FLNC GAB1 HID1 LNCAROD MET PLEK2 SHC1 SORBS1 SORBS3 SRC UBC	11 interacting genes: ANKS1A ARHGEF6 CD2AP CLNK GGA3 INPPL1 PARD6B SAMHD1 SH3KBP1 SNCA TNKS2
Entrez ID		3636	64411
HPRD ID		02900	09441
Ensembl ID		ENSG00000165458	ENSG00000120318
Uniprot IDs		O15357	Q05CH1 Q8WWN8 Q9H7C1
PDB IDs		2K4P 2KSO 2MK2 3NR8 4A9C 5OKM 5OKN 5OKO 5OKP 6SQU 6SRR	2KG5 2LNW 5JCP 5JD0 7A9B 7YIR 7YIS
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus ERBB2 Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Growth Factor Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Focal Adhesion Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Apoptotic Process Signal Transduction Basal Plasma Membrane Ephrin Receptor Binding Plasma Membrane Animal Organ Development Regulation Of Cellular Component Organization Receptor Complex Positive Regulation Of Cell Population Proliferation Protein Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Neuron Differentiation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Biosynthetic Process Positive Regulation Of Protein Phosphorylation Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Protein Tyrosine Kinase Activator Activity Shc-EGFR Complex ERBB3:ERBB2 Complex Kinase Activity Intracellular Signal Transduction	Cell Death ERK1 And ERK2 Cascade Apoptotic Process SH3 Domain Binding Vesicle-mediated Transport Actin Filament Organization Establishment Of Organelle Localization Cell Projection Programmed Cell Death Regulation Of Immune System Process Supramolecular Fiber Organization MAPK Cascade Response To Desipramine Negative Regulation Of Norepinephrine Uptake Protein Complex Oligomerization Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein Destabilization Protein-containing Complex Cell-cell Junction DGTPase Activity DGTP Binding Triphosphoric Monoester Hydrolase Activity Deoxynucleoside Triphosphate Hydrolase Activity Plasma Membrane Bounded Cell Projection Assembly Regulation Of Amide Metabolic Process Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Neuron Projection DATP Catabolic Process DGTP Catabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Projection Assembly Actin Binding Protein Tetramerization Cellular Component Assembly Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Secretion By Cell Anchoring Junction DGTP Metabolic Process Regulated Exocytosis Regulation Of Immune Response Endocytosis Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
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