INPPL1

Gene Name		inositol polyphosphate phosphatase-like 1
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Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Lamellipodium Filopodium
	Molecular Function	Actin Binding Protein Binding Hydrolase Activity SH3 Domain Binding SH2 Domain Binding
	Biological Process	Endochondral Ossification Immune System Process Glucose Metabolic Process Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Actin Filament Organization Cell Adhesion Negative Regulation Of Cell Proliferation Post-embryonic Development Negative Regulation Of Gene Expression Response To Insulin Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation Ruffle Assembly
Pathways		Synthesis of PIPs at the plasma membrane Signaling by Interleukins Interleukin receptor SHC signaling Synthesis of IP3 and IP4 in the cytosol Metabolism of lipids and lipoproteins Interleukin receptor SHC signaling Cytokine Signaling in Immune system Interleukin-2 signaling Phospholipid metabolism Interleukin-3, 5 and GM-CSF signaling Inositol phosphate metabolism PI Metabolism
Drugs
Diseases
GWAS
Protein-protein Interactions		14 interactors: ABL1 BCAR1 CBL CD4 CSF1R EGFR FCGR2B FLNC HID1 MET SHC1 SORBS1 SORBS3 SRC
Entrez ID		3636
HPRD ID		02900
Ensembl ID		ENSG00000165458
Uniprot IDs		O15357
PDB IDs		2K4P 2KSO 3NR8 4A9C
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Transport Cell Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Regulation Of Kinase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Immune Response Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Actin Filament Organization Actin Cytoskeleton Organization Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Signaling Regulation Of Cell Motility Positive Regulation Of Cell Migration Actin Filament-based Process Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Locomotion Regulation Of Locomotion Cell Activation Regulation Of Cellular Component Movement Cell Proliferation Platelet-derived Growth Factor Receptor Signaling Pathway Response To Organic Substance Regulation Of Cellular Amino Acid Metabolic Process
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