CSPG4 and ATF7IP

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		CSPG4	ATF7IP
Description		chondroitin sulfate proteoglycan 4	activating transcription factor 7 interacting protein
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Nucleoplasm Golgi Lumen Plasma Membrane Focal Adhesion Cell Surface Membrane Apical Plasma Membrane Extracellular Matrix Lamellipodium Membrane Cell Projection Lysosomal Lumen Extracellular Exosome	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Nuclear Body
	Molecular Function	Coreceptor Activity Protein Kinase Binding	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding ATP Hydrolysis Activity
	Biological Process	Angiogenesis Substrate-dependent Cell Migration Signal Transduction Glial Cell Migration Cell Differentiation Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Platelet-derived Growth Factor Receptor Signaling Pathway Tissue Remodeling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Ruffle Assembly	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription
Pathways		Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	PKMTs methylate histone lysines Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462) Hip index ( 34021172) Intraocular pressure ( 29617998) Simvastatin-induced myopathy ( 31220337)	Breast cancer ( 24143190) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Height ( 31562340 33713608) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Leukocyte telomere length ( 32109421) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate-specific antigen levels ( 23359319) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240 28604728 28604732)
Interacting Genes		9 interacting genes: ATF7IP BCAR1 C1QA CDC42 GRIP1 GRIP2 MPDZ PTK2 TNK2	71 interacting genes: A2M ACTB ACTG1 AP1B1 CADM1 CEP250 COL4A2 CREB1 CREBBP CSPG4 DISC1 DMTF1 DNM2 EHMT2 EPG5 FLNB FLT4 GMEB1 GTF2E2 GTF2F1 GTF2H1 HEYL HLA-B HMGB1 HSPG2 KIF13A KRT7 LAMA4 LAMA5 LAMC1 LUC7L2 MACF1 MBD1 MCAM MED4 MRI1 NOMO1 NPR1 PAPPA PAPPA2 PCDH1 PEX6 PIAS3 PKD1 PLEKHB2 POLR2C POLR2D POLR2G PRSS8 PSG3 QRICH1 RPS3A RRBP1 SENP3 SETDB1 SLC12A4 SMAD4 SP1 SPTBN1 SREBF2 STBD1 STRN SUMO2 SUSD1 SVEP1 TRIP12 TTC3 UBE2I ZBTB6 ZNF350 ZNF518A
Entrez ID		1464	55729
HPRD ID		03105	09811
Ensembl ID		ENSG00000173546	ENSG00000171681
Uniprot IDs		Q6UVK1	B3KNI7 B3KQF8 Q6VMQ6
PDB IDs		7ML7 7N8X 7N9Y	2RPQ
Enriched GO Terms of Interacting Partners?		Endothelin Receptor Signaling Pathway Integrin-mediated Signaling Pathway Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Endosome To Plasma Membrane Protein Transport Neurotransmitter Receptor Transport Anchoring Junction Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Localization To Synapse Establishment Of Protein Localization To Plasma Membrane Regulation Of Substrate Adhesion-dependent Cell Spreading Protein Localization To Synapse Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Protein-containing Complex Localization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels ERBB Signaling Pathway Endocytic Recycling Protein Localization To Cell Junction Apical Part Of Cell Establishment Of Cell Polarity GBD Domain Binding Storage Vacuole Grb2-EGFR Complex Activation Of Immune Response Focal Adhesion Complement Component C1q Complex Vertebrate Eye-specific Patterning Cell Junction Organization Protein Kinase Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Dendrite Cytoophidium Cell Surface Receptor Signaling Pathway Extrinsic Component Of Presynaptic Membrane Complement-mediated Synapse Pruning Apolipoprotein A-I Receptor Binding Vesicle-mediated Transport Neuropilin Signaling Pathway Plasma Membrane Protein Tyrosine Kinase Activity Vesicle-mediated Transport To The Plasma Membrane IgM Binding	Transcription By RNA Polymerase II DNA-templated Transcription Morphogenesis Of A Polarized Epithelium Transcription Initiation At RNA Polymerase II Promoter Nucleoplasm DNA-templated Transcription Initiation Basement Membrane Laminin-11 Complex Laminin-10 Complex Lymph Vessel Morphogenesis RNA Polymerase II, Core Complex Nucleobase-containing Compound Biosynthetic Process SUMO Transferase Activity Regulation Of Transepithelial Transport Dense Body Regulation Of Multicellular Organismal Development Nuclear Thyroid Hormone Receptor Binding Presynaptic Cytosol Macromolecule Biosynthetic Process Postsynaptic Cytosol Structural Constituent Of Postsynaptic Actin Cytoskeleton Maintenance Of Blood-brain Barrier Proximal Tubule Development Focal Adhesion DNA-directed RNA Polymerase Complex Golgi To Plasma Membrane Protein Transport Histone H3K9me2 Methyltransferase Activity DNA Methylation-dependent Constitutive Heterochromatin Formation Extracellular Exosome Positive Regulation Of Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Histone H3K9 Methyltransferase Activity Nucleus
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