CSPG4 and C1QA

Number of citations of the paper that reports this interaction (PubMedID 9013976)
0

Data Source:
HPRD (in vitro)

		CSPG4	C1QA
Description		chondroitin sulfate proteoglycan 4	complement C1q A chain
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Nucleoplasm Golgi Lumen Plasma Membrane Focal Adhesion Cell Surface Membrane Apical Plasma Membrane Extracellular Matrix Lamellipodium Membrane Cell Projection Lysosomal Lumen Extracellular Exosome	Extracellular Region Collagen Trimer Complement Component C1 Complex Cell Surface Extracellular Matrix Synapse Complement Component C1q Complex Postsynapse Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse Symbiont Cell Surface
	Molecular Function	Coreceptor Activity Protein Kinase Binding	Amyloid-beta Binding Phosphatidylserine Binding IgM Binding Protein Binding IgG Binding
	Biological Process	Angiogenesis Substrate-dependent Cell Migration Signal Transduction Glial Cell Migration Cell Differentiation Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Platelet-derived Growth Factor Receptor Signaling Pathway Tissue Remodeling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Ruffle Assembly	Microglial Cell Activation Immune System Process Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Neuron Remodeling Innate Immune Response Astrocyte Activation Synapse Organization Synapse Pruning Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning
Pathways		Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs			Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab
Diseases			Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Estimated glomerular filtration rate ( 31015462) Hip index ( 34021172) Intraocular pressure ( 29617998) Simvastatin-induced myopathy ( 31220337)	Inflammatory biomarkers (multivariate analysis) ( 33110245)
Interacting Genes		9 interacting genes: ATF7IP BCAR1 C1QA CDC42 GRIP1 GRIP2 MPDZ PTK2 TNK2	31 interacting genes: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HMGB1 HRG HSPB2 NLGN3 PIAS2 PPP1CA PPP1CC PTX3 SGTA SGTB SLC25A47 TXN UBQLN1 UBQLN2 USP40
Entrez ID		1464	712
HPRD ID		03105	00393
Ensembl ID		ENSG00000173546	ENSG00000173372
Uniprot IDs		Q6UVK1	P02745
PDB IDs		7ML7 7N8X 7N9Y	1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V 9C9L 9C9U
Enriched GO Terms of Interacting Partners?		Endothelin Receptor Signaling Pathway Integrin-mediated Signaling Pathway Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Endosome To Plasma Membrane Protein Transport Neurotransmitter Receptor Transport Anchoring Junction Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Localization To Synapse Establishment Of Protein Localization To Plasma Membrane Regulation Of Substrate Adhesion-dependent Cell Spreading Protein Localization To Synapse Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Protein-containing Complex Localization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels ERBB Signaling Pathway Endocytic Recycling Protein Localization To Cell Junction Apical Part Of Cell Establishment Of Cell Polarity GBD Domain Binding Storage Vacuole Grb2-EGFR Complex Activation Of Immune Response Focal Adhesion Complement Component C1q Complex Vertebrate Eye-specific Patterning Cell Junction Organization Protein Kinase Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Dendrite Cytoophidium Cell Surface Receptor Signaling Pathway Extrinsic Component Of Presynaptic Membrane Complement-mediated Synapse Pruning Apolipoprotein A-I Receptor Binding Vesicle-mediated Transport Neuropilin Signaling Pathway Plasma Membrane Protein Tyrosine Kinase Activity Vesicle-mediated Transport To The Plasma Membrane IgM Binding	Complement Component C1q Complex Binding Complement Activation, Classical Pathway Complement Component C1 Complex Complement Activation Blood Microparticle Cell Surface Opsonization Immune Effector Process Positive Regulation Of ERAD Pathway Symbiont Cell Surface Defense Response To Symbiont Defense Response To Other Organism Regulation Of ERAD Pathway Innate Immune Response Regulation Of Protein Metabolic Process Extracellular Region Response To Stress Humoral Immune Response Virion Binding Activation Of Immune Response Extracellular Matrix Positive Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Response To External Biotic Stimulus Regulation Of Immune System Process Immune System Process Positive Regulation Of Immune Response Defense Response Response To Other Organism Negative Regulation By Host Of Viral Glycoprotein Metabolic Process TRC Complex Regulation Of Immune Response Immune Response Extracellular Space Identical Protein Binding Negative Regulation Of Endothelial Cell Migration Complement Component C1q Complex Positive Regulation Of Immune System Process Protein Targeting To ER Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Multicellular Organismal Development Establishment Of Protein Localization To Endoplasmic Reticulum IgM Binding Positive Regulation Of Proteolysis Negative Regulation Of Immune System Process Polyubiquitin Modification-dependent Protein Binding Acute-phase Response Positive Regulation Of Proteasomal Protein Catabolic Process Postsynapse
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