CSPG4

Description		chondroitin sulfate proteoglycan 4
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GO Annotations	Cellular Component	Ruffle Extracellular Region Nucleoplasm Golgi Lumen Plasma Membrane Focal Adhesion Cell Surface Membrane Apical Plasma Membrane Extracellular Matrix Lamellipodium Membrane Cell Projection Lysosomal Lumen Extracellular Exosome
	Molecular Function	Coreceptor Activity Protein Kinase Binding
	Biological Process	Angiogenesis Substrate-dependent Cell Migration Signal Transduction Glial Cell Migration Cell Differentiation Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Platelet-derived Growth Factor Receptor Signaling Pathway Tissue Remodeling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Ruffle Assembly
Pathways		Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462) Hip index ( 34021172) Intraocular pressure ( 29617998) Simvastatin-induced myopathy ( 31220337)
Interacting Genes		9 interacting genes: ATF7IP BCAR1 C1QA CDC42 GRIP1 GRIP2 MPDZ PTK2 TNK2
Entrez ID		1464
HPRD ID		03105
Ensembl ID		ENSG00000173546
Uniprot IDs		Q6UVK1
PDB IDs		7ML7 7N8X 7N9Y
Enriched GO Terms of Interacting Partners?		Endothelin Receptor Signaling Pathway Integrin-mediated Signaling Pathway Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Endosome To Plasma Membrane Protein Transport Neurotransmitter Receptor Transport Anchoring Junction Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Localization To Synapse Establishment Of Protein Localization To Plasma Membrane Regulation Of Substrate Adhesion-dependent Cell Spreading Protein Localization To Synapse Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Protein-containing Complex Localization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels ERBB Signaling Pathway Endocytic Recycling Protein Localization To Cell Junction Apical Part Of Cell Establishment Of Cell Polarity GBD Domain Binding Storage Vacuole Grb2-EGFR Complex Activation Of Immune Response Focal Adhesion Complement Component C1q Complex Vertebrate Eye-specific Patterning Cell Junction Organization Protein Kinase Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Dendrite Cytoophidium Cell Surface Receptor Signaling Pathway Extrinsic Component Of Presynaptic Membrane Complement-mediated Synapse Pruning Apolipoprotein A-I Receptor Binding Vesicle-mediated Transport Neuropilin Signaling Pathway Plasma Membrane Protein Tyrosine Kinase Activity Vesicle-mediated Transport To The Plasma Membrane IgM Binding
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