CSPG4

Gene Name		chondroitin sulfate proteoglycan 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Golgi Lumen Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Apical Plasma Membrane Lamellipodium Membrane Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Protein Kinase Binding
	Biological Process	Activation Of MAPK Activity Angiogenesis Carbohydrate Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Proliferation Glial Cell Migration Pathogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Intracellular Signal Transduction Small Molecule Metabolic Process Tissue Remodeling Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-protein Interactions		9 interactors: ATF7IP BCAR1 C1QA CDC42 GRIP1 GRIP2 MPDZ PTK2 TNK2
Entrez ID		1464
HPRD ID		03105
Ensembl ID		ENSG00000173546
Uniprot IDs		Q6UVK1
PDB IDs
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Establishment Of Nucleus Localization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nucleus Localization Peptidyl-tyrosine Autophosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Phosphatidylinositol 3-kinase Activity Cell Migration Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Lipid Kinase Activity Cell Motility Positive Regulation Of Immune System Process Cell-cell Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Blood Coagulation Hemostasis Immune System Process Immune Response-regulating Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Positive Regulation Of Hair Follicle Cell Proliferation Locomotion Immune Response Regulation Of Immune System Process Signaling Integrin-mediated Signaling Pathway Defense Response Cell Communication Regulation Of Body Fluid Levels Actin Filament Branching Submandibular Salivary Gland Formation Wound Healing Chemotaxis Positive Regulation Of Cellular Metabolic Process Regulation Of Epithelial Cell Migration Movement Of Cell Or Subcellular Component Netrin-activated Signaling Pathway Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Endocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Tagcloud ?		avenues breakthrough checkpoint constituted counteract ctla4 employ helped immunomodulatory immunotherapies immunotherapy interface l1 lethal mcsp melanoma modalities perhaps promise recognised recognising redirect restrict spread standing subsets tumour unexplored vasculature