CSPG4 and TNK2

Number of citations of the paper that reports this interaction (PMID 10587647)
45

Data Source:
HPRD (in vitro, in vivo)

		CSPG4	TNK2
Gene Name		chondroitin sulfate proteoglycan 4	tyrosine kinase, non-receptor, 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Golgi Lumen Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Apical Plasma Membrane Lamellipodium Membrane Lysosomal Lumen Extracellular Vesicular Exosome	Nucleus Cytoplasm Endosome Plasma Membrane Coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuronal Cell Body Grb2-EGFR Complex
	Molecular Function	Signal Transducer Activity Protein Kinase Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Metal Ion Binding WW Domain Binding Hormone Receptor Binding
	Biological Process	Activation Of MAPK Activity Angiogenesis Carbohydrate Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Proliferation Glial Cell Migration Pathogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Intracellular Signal Transduction Small Molecule Metabolic Process Tissue Remodeling Positive Regulation Of Peptidyl-tyrosine Phosphorylation	Endocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase Mediated Signal Transduction Phosphorylation Cell Migration Cell Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Negative Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-mediated Endocytosis
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs			Adenosine triphosphate Debromohymenialdisine
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ATF7IP BCAR1 C1QA CDC42 GRIP1 GRIP2 MPDZ PTK2 TNK2	41 interactors: AQP1 AR ARSE BAG3 CDC42 CLTC CSPG4 CTTN EGFR FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NL NPHP1 RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SIAH1 SMURF1 SNX9 SRC SRSF5 VTI1B WAS WWOX WWP2 YES1
Entrez ID		1464	10188
HPRD ID		03105	06104
Ensembl ID		ENSG00000173546	ENSG00000061938
Uniprot IDs		Q6UVK1	B3KXJ4 C9J1X3 Q07912
PDB IDs			1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Establishment Of Nucleus Localization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nucleus Localization Peptidyl-tyrosine Autophosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Phosphatidylinositol 3-kinase Activity Cell Migration Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Lipid Kinase Activity Cell Motility Positive Regulation Of Immune System Process Cell-cell Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Blood Coagulation Hemostasis Immune System Process Immune Response-regulating Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Positive Regulation Of Hair Follicle Cell Proliferation Locomotion Immune Response Regulation Of Immune System Process Signaling Integrin-mediated Signaling Pathway Defense Response Cell Communication Regulation Of Body Fluid Levels Actin Filament Branching Submandibular Salivary Gland Formation Wound Healing Chemotaxis Positive Regulation Of Cellular Metabolic Process Regulation Of Epithelial Cell Migration Movement Of Cell Or Subcellular Component Netrin-activated Signaling Pathway Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Endocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Phagocytosis Endocytosis Fc Receptor Signaling Pathway Signaling Positive Regulation Of Signal Transduction Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Developmental Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Neuron Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Apoptotic Process Anatomical Structure Development Neuron Projection Development Locomotion Immune Response-regulating Signaling Pathway Cell Migration Regulation Of Cell Death Leukocyte Migration Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Neuron Differentiation T Cell Costimulation Cell Projection Organization Neurogenesis Axon Guidance Nervous System Development Vesicle-mediated Transport Positive Regulation Of Protein Complex Assembly Regulation Of Intracellular Signal Transduction Movement Of Cell Or Subcellular Component System Development Positive Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Generation Of Neurons Neuron Projection Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Multicellular Organismal Development Positive Regulation Of Immune Response Negative Regulation Of Signal Transduction
Tagcloud ?		avenues breakthrough checkpoint constituted counteract ctla4 employ helped immunomodulatory immunotherapies immunotherapy interface l1 lethal mcsp melanoma modalities perhaps promise recognised recognising redirect restrict spread standing subsets tumour unexplored vasculature	ack1 acquire addiction cdc42 demethylase deprivation deregulated doi explosion facets fuel functionality genotoxic hoxa1 insults jhdm2a kdm3a modifies onc publication reality rtk rtks shuttles soon transduce uncovered unfold wherein
Tagcloud (Difference) ?		avenues breakthrough checkpoint constituted counteract ctla4 employ helped immunomodulatory immunotherapies immunotherapy interface l1 lethal mcsp melanoma modalities perhaps promise recognised recognising redirect restrict spread standing subsets tumour unexplored vasculature	ack1 acquire addiction cdc42 demethylase deprivation deregulated doi explosion facets fuel functionality genotoxic hoxa1 insults jhdm2a kdm3a modifies onc publication reality rtk rtks shuttles soon transduce uncovered unfold wherein
Tagcloud (Intersection) ?