PCYT1B and PAXIP1

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		PCYT1B	PAXIP1
Description		phosphate cytidylyltransferase 1B, choline	PAX interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane	Nucleus Nucleoplasm Chromosome Nuclear Matrix Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	Catalytic Activity Choline-phosphate Cytidylyltransferase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity Phosphatidylcholine Binding Identical Protein Binding	Protein Binding
	Biological Process	Ovarian Follicle Development Lipid Metabolic Process Phosphatidylcholine Biosynthetic Process CDP-choline Pathway Spermatogenesis Phospholipid Biosynthetic Process Phosphatidylcholine Metabolic Process Organophosphate Biosynthetic Process	Vasculogenesis DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell Migration Positive Regulation Of Isotype Switching Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Transcription Initiation By RNA Polymerase II Adipose Tissue Development Chorion Development Regulation Of Cell Cycle G2/M Phase Transition
Pathways		Synthesis of PC	Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ) Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		Choline Choline salicylate
Diseases
GWAS			Bladder cancer (smoking interaction) ( 24662972) Metabolite levels ( 23823483)
Interacting Genes		7 interacting genes: ACTA1 ACTA2 APP ECPAS PAXIP1 PCYT1A TMEM43	90 interacting genes: A2M APP ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CIAO2B CLU COMTD1 CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FBLN5 FUCA1 H2AX H3C1 HNRNPLL HSPA14 HSPA4L INTS7 LACTB MAPRE2 MAST1 MRPL33 MT-ND1 MT2A MTIF3 MTNR1A NOS3 NPC2 NUPR1 PAGR1 PAX2 PCBP2 PCYT1B PGGHG PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELENOV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 XAGE1B ZBTB8A ZNF251 ZNF280B
Entrez ID		9468	22976
HPRD ID		05376	08491
Ensembl ID		ENSG00000102230	ENSG00000157212
Uniprot IDs		Q9Y5K3	Q6ZW49
PDB IDs			3SQD
Enriched GO Terms of Interacting Partners?		Cell Body Mesenchyme Migration Positive Regulation Of Hepatic Stellate Cell Contraction Positive Regulation Of Cell Activation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Filopodium Positive Regulation Of Gene Expression Stress Fiber Juxtaglomerular Apparatus Development Positive Regulation Of Hepatic Stellate Cell Migration Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Choline-phosphate Cytidylyltransferase Activity Chorion Development Glomerular Mesangial Cell Development Mesangial Cell Development Positive Regulation Of Hepatic Stellate Cell Activation Smooth Muscle Contractile Fiber Regulation Of Cell Activation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Endoplasmic Reticulum Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Lamellipodium Skeletal Muscle Thin Filament Assembly Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway	Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cytoplasm Protein-DNA Complex
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