PCYT1B and ACTA2

Number of citations: 0 (PubMedID 11580270)
Data Source: HPRD (in vitro)

		PCYT1B	ACTA2
Name		phosphate cytidylyltransferase 1B, choline	actin alpha 2, smooth muscle
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane	Stress Fiber Basement Membrane Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Filopodium Smooth Muscle Contractile Fiber Motile Cilium Protein-containing Complex Cell Body Extracellular Exosome
	Molecular Function	Catalytic Activity Choline-phosphate Cytidylyltransferase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity Phosphatidylcholine Binding Identical Protein Binding	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity Protein Kinase Binding
	Biological Process	Ovarian Follicle Development Lipid Metabolic Process Phosphatidylcholine Biosynthetic Process CDP-choline Pathway Spermatogenesis Phospholipid Biosynthetic Process Phosphatidylcholine Metabolic Process Organophosphate Biosynthetic Process	Muscle Contraction Regulation Of Blood Pressure Response To Virus Positive Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Positive Regulation Of Hepatic Stellate Cell Migration Positive Regulation Of Hepatic Stellate Cell Contraction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Transforming Growth Factor Beta Stimulus Juxtaglomerular Apparatus Development Glomerular Mesangial Cell Development Mesenchyme Migration Positive Regulation Of Hepatic Stellate Cell Activation
Pathways		Synthesis of PC	Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs		Choline Choline salicylate	Phenethyl Isothiocyanate
Diseases		None	Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		No GWAS studies recorded	Arthritis (juvenile idiopathic) ( 33106285 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Chronic lymphocytic leukemia ( 23770605 26956414 ) Immunoglobulin A ( 20694011 ) Lymphocyte percentage of white cells ( 32888494 ) Pulse pressure ( 30578418 ) Selective IgA deficiency ( 27723758 )
Interacting Genes		7 interacting genes: ACTA1 ACTA2 APP ECPAS PAXIP1 PCYT1A TMEM43	18 interacting genes: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SELE SHBG SNTA1 TMSB4X UBE3A YBX1
Entrez ID		9468	59
HPRD ID		05376	00031
Ensembl ID		ENSG00000102230	ENSG00000107796
Uniprot IDs		Q9Y5K3	A0AAQ5BGG7 A0AAQ5BGI6 D2JYH4 P62736
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Cell Body Mesenchyme Migration Positive Regulation Of Hepatic Stellate Cell Contraction Positive Regulation Of Cell Activation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Filopodium Positive Regulation Of Gene Expression Stress Fiber Juxtaglomerular Apparatus Development Positive Regulation Of Hepatic Stellate Cell Migration Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Choline-phosphate Cytidylyltransferase Activity Chorion Development Glomerular Mesangial Cell Development Mesangial Cell Development Positive Regulation Of Hepatic Stellate Cell Activation Smooth Muscle Contractile Fiber Regulation Of Cell Activation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Endoplasmic Reticulum Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Lamellipodium Skeletal Muscle Thin Filament Assembly Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway	Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization Regulation Of Protein Localization To Nucleus Histone H3K27 Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Protein Stabilization Regulation Of Biological Quality Extracellular Exosome Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Regulation Of Protein Localization Actin Binding Regulation Of Protein Stability Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex N-terminal Protein Amino Acid Acetylation Regulation Of Telomerase RNA Localization To Cajal Body Peptidyl-lysine Acetylation Cellular Response To UV Regulation Of Cell Adhesion Regulation Of Organelle Organization Regulation Of Cellular Response To Heat Regulation Of Actin Filament Organization Regulation Of Defense Response Intracellular Signaling Cassette Acetyltransferase Activity Positive Regulation Of DNA Metabolic Process Cellular Response To Light Stimulus Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Actin Filament Polymerization Histone Acetyltransferase Complex Regulation Of Cell-matrix Adhesion Protein-lysine-acetyltransferase Activity Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Neutrophil Activation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Focal Adhesion Assembly Binding Of Sperm To Zona Pellucida Histone Acetyltransferase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Acetylation