SH2D1A and CD84

Number of citations of the paper that reports this interaction (PubMedID 12928397)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SH2D1A	CD84
Description		SH2 domain containing 1A	CD84 molecule
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Protein Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Humoral Immune Response Cellular Defense Response Cell-cell Signaling Natural Killer Cell Activation Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway	Adaptive Immune Response Immune System Process Autophagy Defense Response Immune Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Mast Cell Activation T Cell Activation Negative Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Store-operated Calcium Entry
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Cell surface interactions at the vascular wall
Drugs
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS			Response to anti-TNF therapy in rheumatoid arthritis ( 23555300)
Interacting Genes		32 interacting genes: AR ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB2 ERBB3 ERBB4 FYB1 FYN GRB2 KIT LCK LETMD1 LHX3 LHX4 LY9 MAPK11 MAPK14 MET NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1	2 interacting genes: SH2D1A SH2D1B
Entrez ID		4068	8832
HPRD ID		02390	05151
Ensembl ID		ENSG00000183918	ENSG00000066294
Uniprot IDs		O60880	Q9UIB8
PDB IDs		1D1Z 1D4T 1D4W 1KA6 1KA7 1M27	2PKD
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Lymphocyte Activation Positive Regulation Of Metabolic Process Cell Activation Protein Kinase Activity T Cell Activation Cell Surface Receptor Signaling Pathway Cellular Developmental Process Leukocyte Activation Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Cell Differentiation Regulation Of Immune System Process ERBB Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Protein Phosphatase Binding Regulation Of Multicellular Organismal Process Intracellular Signaling Cassette Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of MAPK Cascade Basal Plasma Membrane Ephrin Receptor Binding Regulation Of Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Immune System Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Lamellipodium Assembly Animal Organ Development Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Apoptotic Process SH2 Domain Binding Adaptive Immune Response	Protein-macromolecule Adaptor Activity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Defense Response To Other Organism Defense Response To Symbiont Positive Regulation Of Lymphocyte Mediated Immunity Response To Other Organism Immune Response Defense Response Response To External Biotic Stimulus Protein Transport Into Plasma Membrane Raft Regulation Of Lymphocyte Mediated Immunity Protein Transport Into Membrane Raft Positive Regulation Of Immune Effector Process Positive Regulation Of Potassium Ion Import Across Plasma Membrane Protein Localization To Plasma Membrane Raft Adaptive Immune Response Positive Regulation Of Innate Immune Response Regulation Of Potassium Ion Import P-type Sodium:potassium-exchanging Transporter Activity Immune System Process Positive Regulation Of Sodium Ion Export Across Plasma Membrane Protein Localization To Membrane Raft Immune Effector Process Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Transporter Activator Activity Sodium:potassium-exchanging ATPase Complex Regulation Of Innate Immune Response Positive Regulation Of Defense Response Relaxation Of Cardiac Muscle Sodium Ion Export Across Plasma Membrane Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Sodium Ion Transmembrane Transport Intracellular Potassium Ion Homeostasis Leukocyte Activation Relaxation Of Muscle Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Cell Communication By Electrical Coupling Cell Communication Involved In Cardiac Conduction Intracellular Sodium Ion Homeostasis Positive Regulation Of Potassium Ion Transmembrane Transport Cell Communication MHC Class II Protein Complex Binding Positive Regulation Of Immune Response Cell Activation ATPase Activator Activity Membrane Repolarization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
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