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SH2D1A and SLAMF7
Number of citations of the paper that reports this interaction (PubMedID
12621057
)
0
Data Source:
HPRD
(two hybrid)
SH2D1A
SLAMF7
Description
SH2 domain containing 1A
SLAM family member 7
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Molecular Function
Protein Binding
Protein-macromolecule Adaptor Activity
Identical Protein Binding
Biological Process
Adaptive Immune Response
Immune System Process
Humoral Immune Response
Cellular Defense Response
Cell-cell Signaling
Natural Killer Cell Activation
Natural Killer Cell Mediated Cytotoxicity
Innate Immune Response
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Regulation Of Immune Response
Negative Regulation Of T Cell Receptor Signaling Pathway
Adaptive Immune Response
Immune System Process
Immune Response
Cell Adhesion
Natural Killer Cell Activation
T Cell Activation
Natural Killer Cell Mediated Cytotoxicity
Innate Immune Response
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Elotuzumab
Diseases
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Blood protein levels (
30072576
)
IgM levels (
28628107
)
Inflammatory bowel disease (
23128233
)
Microalbuminuria (
26631737
)
Multiple sclerosis (
24076602
)
Interacting Genes
32 interacting genes:
AR
ARHGEF6
ARHGEF7
ATF3
CCDC74A
CD84
DOK1
EGFR
ERBB2
ERBB3
ERBB4
FYB1
FYN
GRB2
KIT
LCK
LETMD1
LHX3
LHX4
LY9
MAPK11
MAPK14
MET
NCK1
NGEF
OLIG1
PTK2
SLAMF1
SLAMF6
SLAMF7
TNK2
ZNHIT1
4 interacting genes:
CLK3
MAK
SH2D1A
TRIB2
Entrez ID
4068
57823
HPRD ID
02390
09432
Ensembl ID
ENSG00000183918
ENSG00000026751
Uniprot IDs
O60880
B4DVL7
B4DW98
Q9NQ25
PDB IDs
1D1Z
1D4T
1D4W
1KA6
1KA7
1M27
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Lymphocyte Activation
Positive Regulation Of Metabolic Process
Cell Activation
Protein Kinase Activity
T Cell Activation
Cell Surface Receptor Signaling Pathway
Cellular Developmental Process
Leukocyte Activation
Kinase Activity
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Biosynthetic Process
Cell Differentiation
Regulation Of Immune System Process
ERBB Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Gene Expression
Regulation Of Programmed Cell Death
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Protein Phosphatase Binding
Regulation Of Multicellular Organismal Process
Intracellular Signaling Cassette
Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Ephrin Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Activity
Signal Transduction
ERBB2 Signaling Pathway
Positive Regulation Of MAPK Cascade
Basal Plasma Membrane
Ephrin Receptor Binding
Regulation Of Metabolic Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Negative Regulation Of Programmed Cell Death
Immune System Process
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
Lamellipodium Assembly
Animal Organ Development
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Regulation Of Apoptotic Process
SH2 Domain Binding
Adaptive Immune Response
Cytoplasm
Negative Regulation Of Uterine Smooth Muscle Contraction
Alpha-1B Adrenergic Receptor Binding
Alpha-2C Adrenergic Receptor Binding
Phospholipase C-activating Adrenergic Receptor Signaling Pathway
Protein Homodimerization Activity
Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway
Protein Phosphorylation
Negative Regulation Of Non-motile Cilium Assembly
Skeletal Muscle Tissue Development
Left Lung Morphogenesis
Superior Vena Cava Morphogenesis
Prolactin Secreting Cell Differentiation
Cell Proliferation Involved In Outflow Tract Morphogenesis
Pulmonary Vein Morphogenesis
Subthalamic Nucleus Development
Regulation Of Actin Filament Depolymerization
Actin Filament Capping
Negative Regulation Of Protein-containing Complex Disassembly
Negative Regulation Of Actin Filament Depolymerization
Negative Regulation Of Actin Filament Polymerization
Pantothenate Kinase Activity
Regulation Of Protein Depolymerization
Actin Filament-based Process
Alpha2-adrenergic Receptor Activity
Phosphorylation
Pulmonary Myocardium Development
Endodermal Digestive Tract Morphogenesis
Deltoid Tuberosity Development
Norepinephrine Binding
Thermoception
Somatotropin Secreting Cell Differentiation
Cell Proliferation Involved In Heart Morphogenesis
Acetyl-CoA Binding
Negative Regulation Of Norepinephrine Secretion
Epinephrine Binding
Negative Regulation Of Epinephrine Secretion
Protein Kinase Activity
Striated Muscle Tissue Development
Embryonic Heart Tube Left/right Pattern Formation
Muscle Structure Development
Extraocular Skeletal Muscle Development
Atrioventricular Valve Development
Regulation Of Actin Filament Polymerization
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Filament Length
Regulation Of Protein-containing Complex Disassembly
Negative Regulation Of Protein-containing Complex Assembly
Ubiquitin-protein Transferase Regulator Activity
Pointed-end Actin Filament Capping
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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