SH2D1A and SLAMF1

Number of citations of the paper that reports this interaction (PubMedID 11806999)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SH2D1A	SLAMF1
Description		SH2 domain containing 1A	signaling lymphocytic activation molecule family member 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Virus Receptor Activity Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity SH2 Domain Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Humoral Immune Response Cellular Defense Response Cell-cell Signaling Natural Killer Cell Activation Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway	Natural Killer Cell Differentiation Natural Killer Cell Proliferation Negative Regulation Of Cytokine Production Leukocyte Chemotaxis Involved In Inflammatory Response Adaptive Immune Response Myeloid Dendritic Cell Activation Involved In Immune Response Immune System Process Negative Regulation Of T Cell Cytokine Production Phagocytosis Immune Response Cell Adhesion Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Chemotaxis Regulation Of Vesicle Fusion Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Activated T Cell Proliferation Innate Immune Response Leukocyte Activation Positive Regulation Of JNK Cascade Lymphocyte Activation Symbiont Entry Into Host Cell Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of CD40 Signaling Pathway Positive Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of T-helper 1 Cell Cytokine Production
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS			Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Memory decline ( 31985465) Microalbuminuria ( 26631737) Multiple sclerosis ( 31604244) Schizophrenia (treatment resistant) ( 22479419)
Interacting Genes		32 interacting genes: AR ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB2 ERBB3 ERBB4 FYB1 FYN GRB2 KIT LCK LETMD1 LHX3 LHX4 LY9 MAPK11 MAPK14 MET NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1	6 interacting genes: FGR FYN INPP5D PTPN11 SH2D1A SH2D1B
Entrez ID		4068	6504
HPRD ID		02390	04603
Ensembl ID		ENSG00000183918	ENSG00000117090
Uniprot IDs		O60880	B4E2E4 Q13291
PDB IDs		1D1Z 1D4T 1D4W 1KA6 1KA7 1M27	1D4T 1D4W 1I3Z 1KA6 1KA7 1M27
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Lymphocyte Activation Positive Regulation Of Metabolic Process Cell Activation Protein Kinase Activity T Cell Activation Cell Surface Receptor Signaling Pathway Cellular Developmental Process Leukocyte Activation Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Cell Differentiation Regulation Of Immune System Process ERBB Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Protein Phosphatase Binding Regulation Of Multicellular Organismal Process Intracellular Signaling Cassette Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of MAPK Cascade Basal Plasma Membrane Ephrin Receptor Binding Regulation Of Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Immune System Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Lamellipodium Assembly Animal Organ Development Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Apoptotic Process SH2 Domain Binding Adaptive Immune Response	Immune Effector Process Regulation Of Innate Immune Response Regulation Of Defense Response Regulation Of Immune Response Positive Regulation Of Immune System Process Negative Regulation Of Immune System Process Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Immune Response Adaptive Immune Response Regulation Of Immune System Process Response To Stress Peptide Hormone Receptor Binding Immune System Process Regulation Of Lymphocyte Activation Negative Regulation Of Multicellular Organismal Process Immune Response Negative Regulation Of Lymphocyte Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Leukocyte Activation Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Leukocyte Activation Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Immune Response Innate Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cell Activation Cell Activation Astrocyte Differentiation Negative Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Immunity Immune Response-activating Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Immune Effector Process Defense Response To Other Organism Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Defense Response Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Projection Morphogenesis Neuron Projection Morphogenesis T Cell Costimulation Natural Killer Cell Mediated Immunity Phosphotyrosine Residue Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway Positive Regulation Of Innate Immune Response
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