SH2D1A and ARHGEF7

Number of citations of the paper that reports this interaction (PMID 16983070)
16

Data Source:
HPRD (two hybrid, in vivo)

		SH2D1A	ARHGEF7
Gene Name		SH2 domain containing 1A	Rho guanine nucleotide exchange factor (GEF) 7
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Ruffle Cytosol Focal Adhesion Cell Cortex Lamellipodium Neuron Projection Neuronal Cell Body Protein Complex
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding
	Biological Process	Humoral Immune Response Cellular Defense Response Cell-cell Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	Hematopoietic Progenitor Cell Differentiation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Positive Regulation Of Rac GTPase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Lamellipodium Morphogenesis
Pathways			EGFR downregulation Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE Signaling by Ligand-Responsive EGFR Variants in Cancer p75 NTR receptor-mediated signalling Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Rho GTPase cycle Signaling by EGFR GPCR downstream signaling Ephrin signaling NRAGE signals death through JNK Signaling by Rho GTPases Signaling by EGFR in Cancer EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS			Bilirubin levels ( 19414484) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619)
Protein-Protein Interactions		19 interactors: ARHGEF6 ARHGEF7 CD84 DOK1 EGFR ERBB3 FYB FYN GRB2 LCK LHX4 LY9 MAPK1 MAPK11 MAPK14 SLAMF1 SLAMF6 SLAMF7 TNK2	28 interactors: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 ERBB2IP GIT1 GIT2 LRRK2 MEOX2 NCK1 NCKIPSD PAK1 PAK2 PAK3 PPM1E PPM1F PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 WAS YWHAG
Entrez ID		4068	8874
HPRD ID		02390	05688
Ensembl ID		ENSG00000183918	ENSG00000102606
Uniprot IDs		O60880	B7Z6G2 E9PDQ5 Q14155
PDB IDs		1D1Z 1D4T 1D4W 1KA6 1KA7 1M27	1BY1 1ZSG 2L3G
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Immune System Process Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Intracellular Signal Transduction Innate Immune Response Immune Response Defense Response Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Immune Response Locomotion Response To Fibroblast Growth Factor Immune Response-regulating Cell Surface Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Fc-epsilon Receptor Signaling Pathway Cellular Response To Organic Substance Cell Activation Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Protein Phosphorylation Wound Healing Chemotaxis Response To Stimulus Phosphorylation Positive Regulation Of Immune Response Platelet Activation Response To Organic Substance Axon Guidance Response To Wounding Blood Coagulation Ras Protein Signal Transduction Hemostasis Positive Regulation Of Protein Phosphorylation MAPK Cascade Response To Stress Signal Transduction Cellular Response To Organonitrogen Compound Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Peptide	Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Regulation Of Protein Kinase Activity Regulation Of Signaling Cell Morphogenesis Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Projection Organization Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Programmed Cell Death Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Death Regulation Of Cell Adhesion Regulation Of T Cell Activation Neuron Projection Morphogenesis Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Organelle Organization Positive Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Cell Development Movement Of Cell Or Subcellular Component Regulation Of Cytoskeleton Organization Positive Regulation Of T Cell Activation Neuron Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Actin Cytoskeleton Organization Nervous System Development Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Immune System Process Positive Regulation Of Transferase Activity Axon Guidance Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Anatomical Structure Morphogenesis Regulation Of Actin Filament-based Process Neuron Projection Development
Tagcloud ?		abl1 abl2 arrays bcar3 btk crk domains elisas exquisite fabricated fyn grap2 identity lck lyn monospecific nck1 phage pik3r1 plcgamma1 ptpn11 rasa1 resultant selections shc1 syk vav1 zap70
Tagcloud (Difference) ?		abl1 abl2 arrays bcar3 btk crk domains elisas exquisite fabricated fyn grap2 identity lck lyn monospecific nck1 phage pik3r1 plcgamma1 ptpn11 rasa1 resultant selections shc1 syk vav1 zap70
Tagcloud (Intersection) ?