SH2D1A and SLAMF6

Number of citations of the paper that reports this interaction (PMID 11489943)
39

Data Source:
HPRD (in vitro, in vivo)

		SH2D1A	SLAMF6
Gene Name		SH2 domain containing 1A	SLAM family member 6
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Receptor Activity
	Biological Process	Humoral Immune Response Cellular Defense Response Cell-cell Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways
Drugs
Diseases
GWAS			Graves' disease ( 23612905)
Protein-Protein Interactions		19 interactors: ARHGEF6 ARHGEF7 CD84 DOK1 EGFR ERBB3 FYB FYN GRB2 LCK LHX4 LY9 MAPK1 MAPK11 MAPK14 SLAMF1 SLAMF6 SLAMF7 TNK2	4 interactors: PTPN11 PTPN6 SH2D1A ZAP70
Entrez ID		4068	114836
HPRD ID		02390	05920
Ensembl ID		ENSG00000183918	ENSG00000162739
Uniprot IDs		O60880	B4E1U5 Q96DU3
PDB IDs		1D1Z 1D4T 1D4W 1KA6 1KA7 1M27	2IF7
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Immune System Process Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Intracellular Signal Transduction Innate Immune Response Immune Response Defense Response Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Immune Response Locomotion Response To Fibroblast Growth Factor Immune Response-regulating Cell Surface Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Fc-epsilon Receptor Signaling Pathway Cellular Response To Organic Substance Cell Activation Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Protein Phosphorylation Wound Healing Chemotaxis Response To Stimulus Phosphorylation Positive Regulation Of Immune Response Platelet Activation Response To Organic Substance Axon Guidance Response To Wounding Blood Coagulation Ras Protein Signal Transduction Hemostasis Positive Regulation Of Protein Phosphorylation MAPK Cascade Response To Stress Signal Transduction Cellular Response To Organonitrogen Compound Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Peptide	Abortive Mitotic Cell Cycle Regulation Of Immune Response Megakaryocyte Development Positive Regulation Of Immune System Process Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration Platelet Formation Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Platelet Morphogenesis Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Megakaryocyte Differentiation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Defense Response Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Lymphocyte Activation Immune Response-regulating Signaling Pathway Regulation Of Cell Activation T Cell Costimulation Regulation Of Cell Adhesion Immune System Process Hemopoiesis Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Immune System Development Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Cell Migration Regulation Of Signal Transduction Antigen Receptor-mediated Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of T Cell Proliferation Cell Motility
Tagcloud ?		abl1 abl2 arrays bcar3 btk crk domains elisas exquisite fabricated fyn grap2 identity lck lyn monospecific nck1 phage pik3r1 plcgamma1 ptpn11 rasa1 resultant selections shc1 syk vav1 zap70	accessory antagonize arsenal associate augments bst2 burst cd4 concomitantly counteract cytopathicity defense downmodulate downmodulates downregulate downregulates evolved hiv humanized impair possesses preference profoundly repertoire spread tethers transplanted virions vpu
Tagcloud (Difference) ?		abl1 abl2 arrays bcar3 btk crk domains elisas exquisite fabricated fyn grap2 identity lck lyn monospecific nck1 phage pik3r1 plcgamma1 ptpn11 rasa1 resultant selections shc1 syk vav1 zap70	accessory antagonize arsenal associate augments bst2 burst cd4 concomitantly counteract cytopathicity defense downmodulate downmodulates downregulate downregulates evolved hiv humanized impair possesses preference profoundly repertoire spread tethers transplanted virions vpu
Tagcloud (Intersection) ?