EPHB2 and SDC2

Number of citations of the paper that reports this interaction (PubMedID 11580899)
0

Data Source:
HPRD (in vivo)

		EPHB2	SDC2
Description		EPH receptor B2	syndecan 2
Image
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Cell Surface Membrane Axon Dendrite Presynaptic Membrane Cell Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynapse Glutamatergic Synapse	Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Membrane Extracellular Matrix Lysosomal Lumen
	Molecular Function	Nucleotide Binding Amyloid-beta Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Signaling Receptor Binding Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity Signaling Receptor Activity Identical Protein Binding Protein-containing Complex Binding	Protein Binding PDZ Domain Binding Identical Protein Binding
	Biological Process	Cell Morphogenesis Angiogenesis Urogenital System Development Positive Regulation Of Immunoglobulin Production Negative Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axonogenesis Axon Guidance Axonal Fasciculation Learning Or Memory Learning Animal Organ Morphogenesis Positive Regulation Of Gene Expression Phosphorylation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Retinal Ganglion Cell Axon Guidance Positive Regulation Of Synaptic Plasticity Positive Regulation Of Tumor Necrosis Factor Production B Cell Activation Inner Ear Morphogenesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Camera-type Eye Morphogenesis Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Regulation Of Body Fluid Levels Positive Regulation Of Multicellular Organismal Process Regulation Of Filopodium Assembly Regulation Of Synapse Assembly Positive Regulation Of Synapse Assembly Roof Of Mouth Development Dendritic Spine Development Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Commissural Neuron Axon Guidance Postsynaptic Membrane Assembly Neuron Projection Retraction Vesicle-mediated Intercellular Transport Tight Junction Assembly Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Amyloid-beta Neuron Projection Maintenance Positive Regulation Of Protein Localization To Cell Surface Regulation Of T-helper 17 Type Immune Response Regulation Of Autophagosome Assembly Regulation Of Behavioral Fear Response	Nervous System Development Cell Migration Cell Differentiation Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling L1CAM interactions EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPHB-mediated forward signaling Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Fostamatinib Oleandrin	Sargramostim
Diseases
GWAS		Blood protein levels ( 30072576) Refractive error ( 32231278) Triiodothyronine levels ( 30843173) Triiodothyronine levels and thyroxine levels ( 30843173)	Post-traumatic stress disorder ( 26114229) Refractive error ( 32231278)
Interacting Genes		40 interacting genes: ABL1 ABL2 ACP1 AFDN APP AQP1 ARHGEF6 CRK EFNA5 EFNB1 EFNB2 ERF FBXO7 FOS GRB2 GRIN1 GRIN2B ITSN1 KALRN KSR1 MMP2 MMP9 MTMR14 NCK1 PICK1 PLCG1 PTK2 RASA1 RNF186 RRAS RYK SDC2 SDCBP SH2D3C SRC SYNJ1 TRIM54 VAV2 VEGFA YES1	29 interacting genes: ANOS1 ASPH BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF ITGB4 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4 UBC
Entrez ID		2048	6383
HPRD ID		02997	00803
Ensembl ID		ENSG00000133216	ENSG00000169439
Uniprot IDs		B4DSE0 P29323 Q6NVW1	E9PBI9 P34741
PDB IDs		1B4F 1F0M 2QBX 3ZFM 8EBL	6ITH
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Ephrin Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Regulation Of Locomotion Regulation Of Cell Adhesion Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Cell Migration Cell Projection Organization Positive Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Motility Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Plasma Membrane Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Migration Regulation Of Cell Projection Organization Fc Receptor Mediated Stimulatory Signaling Pathway Intracellular Signal Transduction Regulation Of Organelle Organization Fc Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Cell Motility Cellular Developmental Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Fc-gamma Receptor Signaling Pathway Regulation Of Cell-matrix Adhesion Regulation Of Signal Transduction ERBB Signaling Pathway Regulation Of Endocytosis Positive Regulation Of Immune System Process Regulation Of Cell-substrate Adhesion Regulation Of Signaling Regulation Of Cell Communication Regulation Of Biological Quality Regulation Of Neuron Projection Development Regulation Of Anatomical Structure Morphogenesis Cellular Response To Oxygen-containing Compound Cell Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Multicellular Organismal Process	Extracellular Space Regulation Of Multicellular Organismal Process Platelet Alpha Granule Lumen Extracellular Region Regulation Of Developmental Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Regulation Of MAPK Cascade Regulation Of Wound Healing Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Multicellular Organismal Development Heparin Binding Signaling Receptor Binding Positive Regulation Of Gene Expression Extracellular Matrix Regulation Of Response To Wounding Basement Membrane Signal Transduction Regulation Of Endothelial Cell Migration Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Vasculature Development Response To Wounding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Migration Anatomical Structure Morphogenesis Plasma Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macrophage Differentiation Regulation Of Vesicle-mediated Transport Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Signal Transduction
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?