EPHB2 and ACP1

Number of citations of the paper that reports this interaction (PubMedID 9499402)
45

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		EPHB2	ACP1
Description		EPH receptor B2	acid phosphatase 1
Image
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Cell Surface Membrane Axon Dendrite Presynaptic Membrane Cell Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Sarcolemma Synapse Extracellular Exosome
	Molecular Function	Nucleotide Binding Amyloid-beta Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Signaling Receptor Binding Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity Signaling Receptor Activity Identical Protein Binding Protein-containing Complex Binding	Acid Phosphatase Activity Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity SH3 Domain Binding
	Biological Process	Cell Morphogenesis Angiogenesis Urogenital System Development Positive Regulation Of Immunoglobulin Production Negative Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axonogenesis Axon Guidance Axonal Fasciculation Learning Or Memory Learning Animal Organ Morphogenesis Positive Regulation Of Gene Expression Phosphorylation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Retinal Ganglion Cell Axon Guidance Positive Regulation Of Synaptic Plasticity Positive Regulation Of Tumor Necrosis Factor Production B Cell Activation Inner Ear Morphogenesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Camera-type Eye Morphogenesis Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Regulation Of Body Fluid Levels Positive Regulation Of Multicellular Organismal Process Regulation Of Filopodium Assembly Regulation Of Synapse Assembly Positive Regulation Of Synapse Assembly Roof Of Mouth Development Dendritic Spine Development Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Commissural Neuron Axon Guidance Postsynaptic Membrane Assembly Neuron Projection Retraction Vesicle-mediated Intercellular Transport Tight Junction Assembly Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Amyloid-beta Neuron Projection Maintenance Positive Regulation Of Protein Localization To Cell Surface Regulation Of T-helper 17 Type Immune Response Regulation Of Autophagosome Assembly Regulation Of Behavioral Fear Response	Chemical Synaptic Transmission
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling L1CAM interactions EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Fostamatinib Oleandrin	Adenine 4-Nitrophenyl Phosphate
Diseases
GWAS		Blood protein levels ( 30072576) Refractive error ( 32231278) Triiodothyronine levels ( 30843173) Triiodothyronine levels and thyroxine levels ( 30843173)	Blood protein levels ( 30072576) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Large artery stroke ( 28265093) Night sleep phenotypes ( 27126917) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		40 interacting genes: ABL1 ABL2 ACP1 AFDN APP AQP1 ARHGEF6 CRK EFNA5 EFNB1 EFNB2 ERF FBXO7 FOS GRB2 GRIN1 GRIN2B ITSN1 KALRN KSR1 MMP2 MMP9 MTMR14 NCK1 PICK1 PLCG1 PTK2 RASA1 RNF186 RRAS RYK SDC2 SDCBP SH2D3C SRC SYNJ1 TRIM54 VAV2 VEGFA YES1	16 interacting genes: BARD1 CTNNB1 EPHA2 EPHB1 EPHB2 ERBB2 FABP4 FNBP1L FYN INSR KDR LCK MRPL20 SFMBT1 SPTAN1 ZAP70
Entrez ID		2048	52
HPRD ID		02997	08881
Ensembl ID		ENSG00000133216	ENSG00000143727
Uniprot IDs		B4DSE0 P29323 Q6NVW1	A0A140VK37 P24666 Q59EH3
PDB IDs		1B4F 1F0M 2QBX 3ZFM 8EBL	1XWW 3N8I 4Z99 4Z9A 4Z9B 5JNR 5JNS 5JNT 5KQG 5KQL 5KQM 5KQP 5PNT 6Y2V 6Y2W 7KH8 7UW6
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Ephrin Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Regulation Of Locomotion Regulation Of Cell Adhesion Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Cell Migration Cell Projection Organization Positive Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Motility Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Plasma Membrane Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Migration Regulation Of Cell Projection Organization Fc Receptor Mediated Stimulatory Signaling Pathway Intracellular Signal Transduction Regulation Of Organelle Organization Fc Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Cell Motility Cellular Developmental Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Fc-gamma Receptor Signaling Pathway Regulation Of Cell-matrix Adhesion Regulation Of Signal Transduction ERBB Signaling Pathway Regulation Of Endocytosis Positive Regulation Of Immune System Process Regulation Of Cell-substrate Adhesion Regulation Of Signaling Regulation Of Cell Communication Regulation Of Biological Quality Regulation Of Neuron Projection Development Regulation Of Anatomical Structure Morphogenesis Cellular Response To Oxygen-containing Compound Cell Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Multicellular Organismal Process	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Protein Phosphorylation Phosphorylation Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Dendritic Spine Organization Protein Modification Process Neuron Projection Organization Postsynapse Organization Regulation Of Multicellular Organismal Development Ephrin Receptor Signaling Pathway Ephrin Receptor Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Response To Growth Factor Phosphatidylinositol 3-kinase Binding Cell Migration Transferase Activity Protein Metabolic Process Regulation Of Multicellular Organismal Process Cell Activation Phosphate-containing Compound Metabolic Process Membrane Raft ATP Binding Regulation Of Developmental Process Cell Motility Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Junction Assembly Lymphocyte Activation Cell Surface Receptor Signaling Pathway Regulation Of Cell Junction Assembly Positive Regulation Of Cellular Component Organization Protein Autophosphorylation CD8 Receptor Binding Positive Regulation Of Cell Adhesion Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Regulation Of Lymphocyte Activation Regulation Of Cellular Localization Animal Organ Morphogenesis T Cell Activation Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Cadherin Binding
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