EPHB2 and YES1

Number of citations of the paper that reports this interaction (PubMedID 9632142)
0

Data Source:
BioGRID (pull down)

		EPHB2	YES1
Description		EPH receptor B2	YES proto-oncogene 1, Src family tyrosine kinase
Image
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Cell Surface Membrane Axon Dendrite Presynaptic Membrane Cell Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynapse Glutamatergic Synapse	Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Anchoring Junction
	Molecular Function	Nucleotide Binding Amyloid-beta Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Signaling Receptor Binding Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity Signaling Receptor Activity Identical Protein Binding Protein-containing Complex Binding	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Transmembrane Transporter Binding
	Biological Process	Cell Morphogenesis Angiogenesis Urogenital System Development Positive Regulation Of Immunoglobulin Production Negative Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axonogenesis Axon Guidance Axonal Fasciculation Learning Or Memory Learning Animal Organ Morphogenesis Positive Regulation Of Gene Expression Phosphorylation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Retinal Ganglion Cell Axon Guidance Positive Regulation Of Synaptic Plasticity Positive Regulation Of Tumor Necrosis Factor Production B Cell Activation Inner Ear Morphogenesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Camera-type Eye Morphogenesis Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Regulation Of Body Fluid Levels Positive Regulation Of Multicellular Organismal Process Regulation Of Filopodium Assembly Regulation Of Synapse Assembly Positive Regulation Of Synapse Assembly Roof Of Mouth Development Dendritic Spine Development Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Commissural Neuron Axon Guidance Postsynaptic Membrane Assembly Neuron Projection Retraction Vesicle-mediated Intercellular Transport Tight Junction Assembly Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Amyloid-beta Neuron Projection Maintenance Positive Regulation Of Protein Localization To Cell Surface Regulation Of T-helper 17 Type Immune Response Regulation Of Autophagosome Assembly Regulation Of Behavioral Fear Response	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of D-glucose Transmembrane Transport Cell Differentiation T Cell Costimulation Cellular Response To Platelet-derived Growth Factor Stimulus Protein Modification Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Vascular Permeability Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Leukocyte Migration Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling L1CAM interactions EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	Signaling by ERBB2 Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling FCGR activation PECAM1 interactions EPH-Ephrin signaling Co-stimulation by CD28 Co-inhibition by CTLA4 EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells RUNX2 regulates osteoblast differentiation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF1 (M-CSF) in myeloid cells
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Fostamatinib Oleandrin	Dasatinib Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576) Refractive error ( 32231278) Triiodothyronine levels ( 30843173) Triiodothyronine levels and thyroxine levels ( 30843173)	Diastolic blood pressure ( 29403010 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Pulmonary function in asthmatics ( 23541324) Pursuit maintenance gain ( 29064472) Systolic blood pressure ( 29403010 30224653 30487518 30578418) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020)
Interacting Genes		40 interacting genes: ABL1 ABL2 ACP1 AFDN APP AQP1 ARHGEF6 CRK EFNA5 EFNB1 EFNB2 ERF FBXO7 FOS GRB2 GRIN1 GRIN2B ITSN1 KALRN KSR1 MMP2 MMP9 MTMR14 NCK1 PICK1 PLCG1 PTK2 RASA1 RNF186 RRAS RYK SDC2 SDCBP SH2D3C SRC SYNJ1 TRIM54 VAV2 VEGFA YES1	98 interacting genes: ADAM12 ADAM15 AMOTL2 AR BCAR1 BECN1 BICD2 C1orf94 CARD9 CBL CBLB CBLC CCDC33 CD2AP CD36 CD46 CDH1 CDKN1B CEP57L1 CEP83 CHMP1A CPSF6 CRKL CSF1R DDIT4L DENND2C DES DLG4 DOK1 DOK2 DRC4 DTX3 DVL2 EFS EGFR EPHB2 ERBB2 ERBB3 ERBB4 FASLG FGFR1 FLACC1 FLT1 FUNDC1 FXR1 FXR2 GAB1 GFAP GP6 IKZF3 ITGB4 JAK2 JAKMIP1 KDR KHDRBS1 KIT LASP1 LIN7C MET MST1R NEDD4 NHERF1 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PICK1 PIK3R3 PTEN PTK2 PTPRE RASA1 RPL10 SH3GLB2 SKAP2 SOCS1 SOCS2 SOCS3 SOCS7 SPRR2A SSBP3 STAP2 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRIM5 TRPV4 TSGA10IP TYRO3 ZBTB8A ZC2HC1A ZNF438 ZNF512B
Entrez ID		2048	7525
HPRD ID		02997	01285
Ensembl ID		ENSG00000133216	ENSG00000176105
Uniprot IDs		B4DSE0 P29323 Q6NVW1	P07947
PDB IDs		1B4F 1F0M 2QBX 3ZFM 8EBL	2HDA
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Ephrin Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Regulation Of Locomotion Regulation Of Cell Adhesion Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Cell Migration Cell Projection Organization Positive Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Motility Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Plasma Membrane Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Migration Regulation Of Cell Projection Organization Fc Receptor Mediated Stimulatory Signaling Pathway Intracellular Signal Transduction Regulation Of Organelle Organization Fc Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Cell Motility Cellular Developmental Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Fc-gamma Receptor Signaling Pathway Regulation Of Cell-matrix Adhesion Regulation Of Signal Transduction ERBB Signaling Pathway Regulation Of Endocytosis Positive Regulation Of Immune System Process Regulation Of Cell-substrate Adhesion Regulation Of Signaling Regulation Of Cell Communication Regulation Of Biological Quality Regulation Of Neuron Projection Development Regulation Of Anatomical Structure Morphogenesis Cellular Response To Oxygen-containing Compound Cell Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Multicellular Organismal Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Receptor Complex Positive Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Identical Protein Binding Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Cell Migration Regulation Of Apoptotic Process Plasma Membrane Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Motility Regulation Of Developmental Process Cell Migration Negative Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Regulation Of Locomotion Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Positive Regulation Of Protein Modification Process Protein Kinase Activity Cell Motility SH3 Domain Binding Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Protein Binding Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cell Population Proliferation
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