EPHB2 and ITSN1

Number of citations of the paper that reports this interaction (PMID 12389031)
67

Data Source:
HPRD (in vivo)

		EPHB2	ITSN1
Gene Name		EPH receptor B2	intersectin 1 (SH3 domain protein)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Neuronal Cell Body	Cytosol Plasma Membrane Coated Pit Lamellipodium Cell Junction Endocytic Vesicle Neuron Projection Synapse
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Receptor Binding Protein Binding ATP Binding Axon Guidance Receptor Activity	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Kinase Activator Activity Protein Complex Scaffold Proline-rich Region Binding
	Biological Process	Angiogenesis Urogenital System Development Nervous System Development Axon Guidance Axonal Fasciculation Learning Phosphorylation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Retinal Ganglion Cell Axon Guidance Inner Ear Morphogenesis Ephrin Receptor Signaling Pathway Positive Regulation Of Long-term Neuronal Synaptic Plasticity Camera-type Eye Morphogenesis Negative Regulation Of Axonogenesis Regulation Of Body Fluid Levels Positive Regulation Of Synapse Assembly Palate Development Dendritic Spine Development Dendritic Spine Morphogenesis Commissural Neuron Axon Guidance	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway
Pathways		EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling L1CAM interactions	Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHB-mediated forward signaling GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: ABL1 ABL2 ACP1 AQP1 ARHGEF6 BCL2 CRK EFNA5 EFNB1 EFNB2 ERF FOS GRB2 GRIN1 GRIN2B ITSN1 KALRN KSR1 MLLT4 MMP2 MMP9 NCK1 PICK1 PLCG1 PTK2 RASA1 RRAS RYK SDC2 SDCBP SH2D3C SRC SYNJ1 VAV2 VEGFA YES1	82 interactors: AGFG1 AGFG2 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHSD2 FNBP1 FNBP4 GAREML GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 RAB11FIP2 RAB5A RABEP1 RAI14 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SH3GL2 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 WASL WBP11 ZAK ZFPM2
Entrez ID		2048	6453
HPRD ID		02997	03898
Ensembl ID		ENSG00000133216	ENSG00000205726
Uniprot IDs		P29323	A7XZY7 F8W7U0 Q15811 Q6PD56
PDB IDs		1B4F 1F0M 2QBX	1KI1 2KGR 2KHN 3FIA 3QBV 4IIM
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Ephrin Receptor Signaling Pathway Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Neuron Development Cell Projection Morphogenesis Cell Projection Organization Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Neuron Differentiation Cell Morphogenesis Response To External Stimulus Generation Of Neurons Cell Development Neurogenesis Locomotion Nervous System Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Signaling Cell Communication Cell Differentiation Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction System Development Regulation Of Signaling Cellular Response To Stimulus Anatomical Structure Development Multicellular Organismal Development Developmental Process Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Response To Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Cell Migration Regulation Of Phosphorus Metabolic Process	Vesicle-mediated Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Endocytosis Vesicle Organization Cellular Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Signaling Synaptic Transmission Regulation Of Cellular Component Organization Establishment Of Organelle Localization Cell Communication Regulation Of Signaling Organelle Organization Protein Localization Cell Differentiation Synaptic Vesicle Transport Cell-cell Signaling Membrane Budding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Localization Regulation Of ERBB Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Establishment Of Vesicle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vesicle Localization Transport Cell Morphogenesis Involved In Neuron Differentiation Axon Guidance Generation Of Neurons Cell Morphogenesis Involved In Differentiation Membrane Organization Cell Projection Morphogenesis Cell Part Morphogenesis Establishment Of Protein Localization Cell Projection Organization Synaptic Vesicle Recycling Axonogenesis Cellular Protein Complex Assembly Neurogenesis Regulation Of Catalytic Activity Regulation Of Signal Transduction Intracellular Transport Cell Morphogenesis
Tagcloud ?		10a1 10ca1a 3d array beta3 emt ephrin impede inhibits integrin interplay intricate invasion mcf mesenchymal metallo migration mmp9 modulated nmumg nutlin p53 proteinase spheroid tgf transforming transwell verification whereby	cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3
Tagcloud (Difference) ?		10a1 10ca1a 3d array beta3 emt ephrin impede inhibits integrin interplay intricate invasion mcf mesenchymal metallo migration mmp9 modulated nmumg nutlin p53 proteinase spheroid tgf transforming transwell verification whereby	cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3
Tagcloud (Intersection) ?