EPHB2 and KALRN

Number of citations of the paper that reports this interaction (PubMedID 12546821)
0

Data Source:
HPRD (in vitro)

		EPHB2	KALRN
Description		EPH receptor B2	kalirin RhoGEF kinase
Image
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Cell Surface Membrane Axon Dendrite Presynaptic Membrane Cell Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynapse Glutamatergic Synapse	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Postsynaptic Density Actin Cytoskeleton Extrinsic Component Of Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Amyloid-beta Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Signaling Receptor Binding Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity Signaling Receptor Activity Identical Protein Binding Protein-containing Complex Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Cell Morphogenesis Angiogenesis Urogenital System Development Positive Regulation Of Immunoglobulin Production Negative Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axonogenesis Axon Guidance Axonal Fasciculation Learning Or Memory Learning Animal Organ Morphogenesis Positive Regulation Of Gene Expression Phosphorylation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Retinal Ganglion Cell Axon Guidance Positive Regulation Of Synaptic Plasticity Positive Regulation Of Tumor Necrosis Factor Production B Cell Activation Inner Ear Morphogenesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Camera-type Eye Morphogenesis Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Regulation Of Body Fluid Levels Positive Regulation Of Multicellular Organismal Process Regulation Of Filopodium Assembly Regulation Of Synapse Assembly Positive Regulation Of Synapse Assembly Roof Of Mouth Development Dendritic Spine Development Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Commissural Neuron Axon Guidance Postsynaptic Membrane Assembly Neuron Projection Retraction Vesicle-mediated Intercellular Transport Tight Junction Assembly Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Amyloid-beta Neuron Projection Maintenance Positive Regulation Of Protein Localization To Cell Surface Regulation Of T-helper 17 Type Immune Response Regulation Of Autophagosome Assembly Regulation Of Behavioral Fear Response	Protein Phosphorylation Signal Transduction Nervous System Development Axon Guidance Vesicle-mediated Transport Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling L1CAM interactions EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	NRAGE signals death through JNK EPHB-mediated forward signaling G alpha (q) signalling events G alpha (12/13) signalling events MAPK6/MAPK4 signaling RHOA GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Fostamatinib Oleandrin
Diseases
GWAS		Blood protein levels ( 30072576) Refractive error ( 32231278) Triiodothyronine levels ( 30843173) Triiodothyronine levels and thyroxine levels ( 30843173)	Acute graft versus host disease in bone marrow transplantation (donor effect) ( 27595289) Amyotrophic lateral sclerosis ( 26580837) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Diffuse large B-cell lymphoma or systemic lupus erythematosus ( 31407831) General cognitive ability ( 29844566) Hematocrit ( 32888494) Heschl's gyrus morphology ( 25130324) Intraocular pressure ( 31959993 29785010 29617998) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Longevity (age >99th survival percentile) ( 31413261) Low urine pH ( 30476138) Lymphocyte count ( 32888494) Marginal zone lymphoma or systemic lupus erythematosus ( 31407831) Mean platelet volume ( 22139419 27863252 32888494) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Monocyte count ( 32888494) Myocardial infarction ( 33532862) Neutrophil percentage of white cells ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Red cell distribution width ( 32888494) Schizophrenia ( 30285260) Stroke ( 32693751) Systolic blood pressure x dichotomous lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373) Thyroid peroxidase antibody levels ( 24586183) Urine pH measurement ( 30476138)
Interacting Genes		40 interacting genes: ABL1 ABL2 ACP1 AFDN APP AQP1 ARHGEF6 CRK EFNA5 EFNB1 EFNB2 ERF FBXO7 FOS GRB2 GRIN1 GRIN2B ITSN1 KALRN KSR1 MMP2 MMP9 MTMR14 NCK1 PICK1 PLCG1 PTK2 RASA1 RNF186 RRAS RYK SDC2 SDCBP SH2D3C SRC SYNJ1 TRIM54 VAV2 VEGFA YES1	22 interacting genes: ATXN7 CACNA1A CDC5L COIL DISC1 DSCAM DSCR9 DTNBP1 ENO3 EPHB2 FASLG GFI1B GRIK1 LNX1 MORC3 NDEL1 NRIP1 PAM PCNT SPTAN1 SUMO2 SUMO3
Entrez ID		2048	8997
HPRD ID		02997	06859
Ensembl ID		ENSG00000133216	ENSG00000160145
Uniprot IDs		B4DSE0 P29323 Q6NVW1	A0A804HI91 A0A804HIN3 A0A804HKJ7 A0A804HKT9 C9IZQ6 O60229
PDB IDs		1B4F 1F0M 2QBX 3ZFM 8EBL	5QQD 5QQE 5QQF 5QQG 5QQH 5QQI 5QQJ 5QQK 5QQL 5QQM 5QQN 5QU9 8C7D
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Ephrin Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Regulation Of Locomotion Regulation Of Cell Adhesion Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Cell Migration Cell Projection Organization Positive Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Motility Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Plasma Membrane Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Migration Regulation Of Cell Projection Organization Fc Receptor Mediated Stimulatory Signaling Pathway Intracellular Signal Transduction Regulation Of Organelle Organization Fc Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Cell Motility Cellular Developmental Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Fc-gamma Receptor Signaling Pathway Regulation Of Cell-matrix Adhesion Regulation Of Signal Transduction ERBB Signaling Pathway Regulation Of Endocytosis Positive Regulation Of Immune System Process Regulation Of Cell-substrate Adhesion Regulation Of Signaling Regulation Of Cell Communication Regulation Of Biological Quality Regulation Of Neuron Projection Development Regulation Of Anatomical Structure Morphogenesis Cellular Response To Oxygen-containing Compound Cell Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Multicellular Organismal Process	Hippocampal Mossy Fiber To CA3 Synapse Radial Glia-guided Pyramidal Neuron Migration Regulation Of Dendritic Spine Development Nervous System Development Axon Dendritic Spine Development Regulation Of Synaptic Transmission, Glutamatergic Protein Tag Activity Regulation Of Neuron Projection Development Modulation Of Chemical Synaptic Transmission Cell Projection Morphogenesis Neuron Projection Morphogenesis Microtubule Organizing Center PML Body Cerebral Cortex Radially Oriented Cell Migration Ubiquitin-like Protein Ligase Binding Nuclear Matrix Microtubule Nucleation Cerebral Cortex Cell Migration Regulation Of Axonogenesis Central Nervous System Neuron Axonogenesis Regulation Of Postsynapse Organization Neuronal Cell Body Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Axon Extension Synaptic Transmission, Glutamatergic Neuron Recognition System Development Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Dendritic Spine Morphogenesis Peptidylamidoglycolate Lyase Activity Peptidylglycine Monooxygenase Activity Fatty Acid Primary Amide Biosynthetic Process Cytoskeleton Organization Ovarian Follicle Rupture Telencephalon Cell Migration Forebrain Cell Migration Kinesin Complex Vesicle Transport Along Microtubule Dendrite Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Cellular Response To Amyloid-beta Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Cell Projection Organization Neuron Projection Retraction Negative Regulation Of Glutamate Receptor Signaling Pathway Peptide Amidation
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