CDK6 and PPARGC1A

Number of citations of the paper that reports this interaction (PMID 22094256)
37

Data Source:
BioGRID (enzymatic study)

		CDK6	PPARGC1A
Gene Name		cyclin-dependent kinase 6	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
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Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex Cytosol PML Body
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin Binding	Nucleotide Binding RNA Polymerase II Transcription Cofactor Activity DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding Ligand-dependent Nuclear Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Chromatin DNA Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Androgen Receptor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Positive Regulation Of Cell-matrix Adhesion Type B Pancreatic Cell Development Protein Phosphorylation Cell Cycle Arrest Notch Signaling Pathway Negative Regulation Of Cell Proliferation Response To Virus Regulation Of Gene Expression Positive Regulation Of Gene Expression Astrocyte Development Dentate Gyrus Development Lateral Ventricle Development T Cell Differentiation In Thymus Gliogenesis Cell Dedifferentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Cell Division Hematopoietic Stem Cell Differentiation Regulation Of Cell Motility Negative Regulation Of Cellular Senescence	Temperature Homeostasis Cellular Glucose Homeostasis Galactose Metabolic Process Gluconeogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter MRNA Processing Protein Complex Assembly Organelle Organization Mitochondrion Organization Digestion Circadian Rhythm Androgen Metabolic Process RNA Splicing Response To Cold Positive Regulation Of Mitochondrion Organization Response To Muscle Activity Fatty Acid Oxidation Respiratory Electron Transport Chain Androgen Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Positive Regulation Of Histone Acetylation Response To Statin Response To Starvation Regulation Of Circadian Rhythm Response To Leucine Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Gluconeogenesis Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Brown Fat Cell Differentiation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Flavone Metabolic Process Cellular Response To Nitrite Cellular Response To Tumor Necrosis Factor Cellular Response To Fatty Acid Cellular Response To Hypoxia Response To Epinephrine Response To Norepinephrine Cellular Response To Thyroid Hormone Stimulus Negative Regulation Of Neuron Death Positive Regulation Of Cellular Respiration Positive Regulation Of Mitochondrial DNA Metabolic Process Positive Regulation Of Muscle Tissue Development Negative Regulation Of Receptor Activity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Energy Homeostasis Positive Regulation Of ATP Biosynthetic Process
Pathways		Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic	PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Activation of PPARGC1A (PGC-1alpha) by phosphorylation Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS		Height ( 20881960 19343178 23563607 18391950 18391951 18391952) Rheumatoid arthritis ( 18794853) White blood cell count ( 20139978 21738479) White blood cell types ( 21738478)	Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		92 interactors: ABI2 ANKRD12 AR ATF6B ATXN1 BCL11A CASC3 CBY1 CCND1 CCND3 CDC37 CDC6 CDK7 CDKN1A CDKN2A CDKN2B CDKN2C CDKN2D CLASRP CNOT7 CTNNB1 DAB1 DDIT3 DEDD2 EBF4 EIF4ENIF1 ELK1 EZH2 FOXM1 FOXO3 HIST1H1A HSF1 ISL1 KIF26B KLF10 LPIN1 MCM10 MCM2 MEF2D MLLT3 MSL3 MYC MZF1 N4BP1 NFATC3 NIPBL NUMA1 PCNA PML POGZ PPARGC1A PPHLN1 PPM1B PPP2CA PRX PSMA3 RB1 RBL1 RBL2 RBM23 RUNX1 SENP3 SIRT1 SLBP SNIP1 SORBS1 SOX10 SOX5 SRSF1 SRSF11 SRSF12 SRSF2 SRSF7 SSBP2 SYNPO2 TCEB3B TFDP1 TGFBR1 TJP2 TPX2 TRA2A TRA2B TRAK1 UHRF2 VGLL4 ZEB1 ZFP36 ZMYM3 ZNF101 ZNF174 ZNF335 ZSCAN1	40 interactors: CAPNS1 CDK6 CREBBP CREBZF ESR1 ESR2 ESRRA ESRRG FBXW7 GSK3B HCFC1 HNF4A LRPPRC MAPK14 MED1 MED12 MED14 MED17 MYBBP1A NCL NCOA1 NCOA6 NR1H4 NR1I2 NR1I3 NR3C1 NRF1 PPARA PPARD PPARG RXRA SIRT1 SRSF4 SRSF5 SRSF6 THRB TP53 UBC UBE2I USF2
Entrez ID		1021	10891
HPRD ID		04533	05155
Ensembl ID		ENSG00000105810	ENSG00000109819
Uniprot IDs		A4D1G0 Q00534	I3RTT5 I3RTT6 Q9UBK2
PDB IDs		1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX 4AUA 4EZ5	1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Cell Cycle Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cell Cycle Process Positive Regulation Of Cellular Biosynthetic Process Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Metabolic Process RNA Processing Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter	Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway Steroid Hormone Mediated Signaling Pathway RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Gene Expression Cellular Response To Steroid Hormone Stimulus Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Steroid Hormone Cellular Nitrogen Compound Metabolic Process Cellular Response To Lipid Biosynthetic Process Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Organic Cyclic Compound Regulation Of Metabolic Process Response To Hormone Negative Regulation Of Biosynthetic Process Response To Lipid Cellular Response To Hormone Stimulus Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Organic Cyclic Compound Cellular Response To Organic Substance Response To Organic Substance
Tagcloud ?		a134c abp allelic ankyrin balb cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	ageing bisulfite chosen coefficients concordance cord d4z4 environage epigenetics foetal loop methylation mitochondrial mt nineteen ninety placenta placental pyrosequencing ranging reproductive rnr1 scheme sides signature sirt1 subtelomeric tfam
Tagcloud (Difference) ?		a134c abp allelic ankyrin balb cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	ageing bisulfite chosen coefficients concordance cord d4z4 environage epigenetics foetal loop methylation mitochondrial mt nineteen ninety placenta placental pyrosequencing ranging reproductive rnr1 scheme sides signature sirt1 subtelomeric tfam
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