CDK6 and LPIN1

Number of citations of the paper that reports this interaction (PMID 22094256)
37

Data Source:
BioGRID (enzymatic study)

		CDK6	LPIN1
Gene Name		cyclin-dependent kinase 6	lipin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nuclear Envelope Nucleoplasm Transcription Factor Complex Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Nuclear Membrane
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin Binding	RNA Polymerase II Transcription Factor Binding Molecular_function Transcription Coactivator Activity Phosphatidate Phosphatase Activity Histone Deacetylase Binding Peroxisome Proliferator Activated Receptor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Positive Regulation Of Cell-matrix Adhesion Type B Pancreatic Cell Development Protein Phosphorylation Cell Cycle Arrest Notch Signaling Pathway Negative Regulation Of Cell Proliferation Response To Virus Regulation Of Gene Expression Positive Regulation Of Gene Expression Astrocyte Development Dentate Gyrus Development Lateral Ventricle Development T Cell Differentiation In Thymus Gliogenesis Cell Dedifferentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Cell Division Hematopoietic Stem Cell Differentiation Regulation Of Cell Motility Negative Regulation Of Cellular Senescence	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitochondrial Fission Mitotic Cell Cycle Transcription, DNA-templated Triglyceride Mobilization Phospholipid Metabolic Process Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process Mitotic Nuclear Envelope Disassembly Fatty Acid Catabolic Process Dephosphorylation Triglyceride Biosynthetic Process Positive Regulation Of Histone Deacetylation Organ Regeneration Ruffle Organization Actin Cytoskeleton Reorganization Cellular Response To Insulin Stimulus Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Glycerophospholipid Biosynthetic Process
Pathways		Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic	Synthesis of PC Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Mitotic Prophase Depolymerisation of the Nuclear Lamina Nuclear Envelope Breakdown Glycerophospholipid biosynthesis M Phase Cell Cycle, Mitotic Synthesis of PE Phospholipid metabolism Triglyceride Biosynthesis
Drugs
Diseases
GWAS		Height ( 20881960 19343178 23563607 18391950 18391951 18391952) Rheumatoid arthritis ( 18794853) White blood cell count ( 20139978 21738479) White blood cell types ( 21738478)
Protein-Protein Interactions		92 interactors: ABI2 ANKRD12 AR ATF6B ATXN1 BCL11A CASC3 CBY1 CCND1 CCND3 CDC37 CDC6 CDK7 CDKN1A CDKN2A CDKN2B CDKN2C CDKN2D CLASRP CNOT7 CTNNB1 DAB1 DDIT3 DEDD2 EBF4 EIF4ENIF1 ELK1 EZH2 FOXM1 FOXO3 HIST1H1A HSF1 ISL1 KIF26B KLF10 LPIN1 MCM10 MCM2 MEF2D MLLT3 MSL3 MYC MZF1 N4BP1 NFATC3 NIPBL NUMA1 PCNA PML POGZ PPARGC1A PPHLN1 PPM1B PPP2CA PRX PSMA3 RB1 RBL1 RBL2 RBM23 RUNX1 SENP3 SIRT1 SLBP SNIP1 SORBS1 SOX10 SOX5 SRSF1 SRSF11 SRSF12 SRSF2 SRSF7 SSBP2 SYNPO2 TCEB3B TFDP1 TGFBR1 TJP2 TPX2 TRA2A TRA2B TRAK1 UHRF2 VGLL4 ZEB1 ZFP36 ZMYM3 ZNF101 ZNF174 ZNF335 ZSCAN1	1 interactors: CDK6
Entrez ID		1021	23175
HPRD ID		04533	09271
Ensembl ID		ENSG00000105810	ENSG00000134324
Uniprot IDs		A4D1G0 Q00534	A8MU38 B4DGS4 F5GY24 Q14693
PDB IDs		1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX 4AUA 4EZ5
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Cell Cycle Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cell Cycle Process Positive Regulation Of Cellular Biosynthetic Process Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Metabolic Process RNA Processing Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter	Cell Dedifferentiation Negative Regulation Of Cellular Senescence Hematopoietic Stem Cell Differentiation Negative Regulation Of Cell Aging Dentate Gyrus Development Type B Pancreatic Cell Development Astrocyte Development Type B Pancreatic Cell Differentiation Lateral Ventricle Development Enteroendocrine Cell Differentiation Regulation Of Cellular Senescence Glandular Epithelial Cell Development Regulation Of Erythrocyte Differentiation Astrocyte Differentiation Ventricular System Development Columnar/cuboidal Epithelial Cell Development Glandular Epithelial Cell Differentiation Negative Regulation Of Osteoblast Differentiation Endocrine Pancreas Development Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Fibroblast Proliferation T Cell Differentiation In Thymus Hippocampus Development Negative Regulation Of Ossification Negative Regulation Of Myeloid Cell Differentiation Pancreas Development Regulation Of Fibroblast Proliferation Limbic System Development Glial Cell Development Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Epithelial Cell Proliferation Regulation Of Osteoblast Differentiation Notch Signaling Pathway Cell Cycle Arrest Hematopoietic Progenitor Cell Differentiation T Cell Differentiation G1/S Transition Of Mitotic Cell Cycle Regulation Of Myeloid Cell Differentiation Glial Cell Differentiation Regulation Of Cell-substrate Adhesion Regulation Of Ossification Pallium Development Epithelial Cell Development Lymphocyte Differentiation Gliogenesis Mitotic Cell Cycle Phase Transition Response To Virus Cell Cycle Phase Transition T Cell Aggregation
Tagcloud ?		a134c abp allelic ankyrin balb cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin2 majeed nlsd perilipin pnpla2 pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Difference) ?		a134c abp allelic ankyrin balb cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipe lipodystrophy loosing lpin2 majeed nlsd perilipin pnpla2 pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Intersection) ?