CDK6 and FOXM1

Number of citations of the paper that reports this interaction (PMID 22094256)
37

Data Source:
BioGRID (enzymatic study)

		CDK6	FOXM1
Gene Name		cyclin-dependent kinase 6	forkhead box M1
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Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleoplasm Cytoplasm
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Positive Regulation Of Cell-matrix Adhesion Type B Pancreatic Cell Development Protein Phosphorylation Cell Cycle Arrest Notch Signaling Pathway Negative Regulation Of Cell Proliferation Response To Virus Regulation Of Gene Expression Positive Regulation Of Gene Expression Astrocyte Development Dentate Gyrus Development Lateral Ventricle Development T Cell Differentiation In Thymus Gliogenesis Cell Dedifferentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Cell Division Hematopoietic Stem Cell Differentiation Regulation Of Cell Motility Negative Regulation Of Cellular Senescence	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Regulation Of Cell Growth Vasculogenesis Liver Development DNA Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Cell Cycle Positive Regulation Of Cell Proliferation Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Cell Proliferation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ras Protein Signal Transduction Regulation Of Cell Cycle Regulation Of Cell Cycle Arrest Negative Regulation Of Cell Aging Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Double-strand Break Repair
Pathways		Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic	Cyclin A/B1 associated events during G2/M transition G2/M Transition Mitotic G2-G2/M phases Cell Cycle, Mitotic Polo-like kinase mediated events
Drugs
Diseases
GWAS		Height ( 20881960 19343178 23563607 18391950 18391951 18391952) Rheumatoid arthritis ( 18794853) White blood cell count ( 20139978 21738479) White blood cell types ( 21738478)
Protein-Protein Interactions		92 interactors: ABI2 ANKRD12 AR ATF6B ATXN1 BCL11A CASC3 CBY1 CCND1 CCND3 CDC37 CDC6 CDK7 CDKN1A CDKN2A CDKN2B CDKN2C CDKN2D CLASRP CNOT7 CTNNB1 DAB1 DDIT3 DEDD2 EBF4 EIF4ENIF1 ELK1 EZH2 FOXM1 FOXO3 HIST1H1A HSF1 ISL1 KIF26B KLF10 LPIN1 MCM10 MCM2 MEF2D MLLT3 MSL3 MYC MZF1 N4BP1 NFATC3 NIPBL NUMA1 PCNA PML POGZ PPARGC1A PPHLN1 PPM1B PPP2CA PRX PSMA3 RB1 RBL1 RBL2 RBM23 RUNX1 SENP3 SIRT1 SLBP SNIP1 SORBS1 SOX10 SOX5 SRSF1 SRSF11 SRSF12 SRSF2 SRSF7 SSBP2 SYNPO2 TCEB3B TFDP1 TGFBR1 TJP2 TPX2 TRA2A TRA2B TRAK1 UHRF2 VGLL4 ZEB1 ZFP36 ZMYM3 ZNF101 ZNF174 ZNF335 ZSCAN1	13 interactors: BANP CCNE1 CDK1 CDK2 CDK4 CDK6 CHEK2 CREBBP OS9 STAT3 SUMO1 UBE2I ZBTB3
Entrez ID		1021	2305
HPRD ID		04533	03823
Ensembl ID		ENSG00000105810	ENSG00000111206
Uniprot IDs		A4D1G0 Q00534	A8K591 Q08050 Q53Y49
PDB IDs		1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX 4AUA 4EZ5	3G73
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Cell Cycle Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cell Cycle Process Positive Regulation Of Cellular Biosynthetic Process Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Metabolic Process RNA Processing Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter	Cell Division Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Regulation Of Gene Expression Cell Cycle Positive Regulation Of Gene Expression Cellular Protein Modification Process Cell Cycle Process Positive Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Protein Localization To Organelle Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Metabolic Process Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Mitotic DNA Damage Checkpoint Phosphorylation Mitotic Nuclear Division Mitotic DNA Integrity Checkpoint Regulation Of Nitrogen Compound Metabolic Process Chromatin Organization Protein Phosphorylation G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Protein Metabolic Process Cellular Macromolecule Catabolic Process Protein Metabolic Process Organelle Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Damage Checkpoint Cellular Response To Stress Mitotic Cell Cycle Checkpoint Protein Sumoylation Protein Localization To Nucleus
Tagcloud ?		a134c abp allelic ankyrin balb cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	axis caenorhabditis catalytic coexpressed collectively contributes driven elegans evolutionarily ezh2 gbm glioblastoma gsc gscs inversely irradiation melk mitotic oncogenic phosphorylates polycomb possibility postirradiation radioresistance raise repressive serve tumorigenic turn
Tagcloud (Difference) ?		a134c abp allelic ankyrin balb cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	axis caenorhabditis catalytic coexpressed collectively contributes driven elegans evolutionarily ezh2 gbm glioblastoma gsc gscs inversely irradiation melk mitotic oncogenic phosphorylates polycomb possibility postirradiation radioresistance raise repressive serve tumorigenic turn
Tagcloud (Intersection) ?