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CDK6 and PPHLN1
Number of citations of the paper that reports this interaction (PMID
22094256
)
37
Data Source:
BioGRID
(enzymatic study)
CDK6
PPHLN1
Gene Name
cyclin-dependent kinase 6
periphilin 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Ruffle
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleoplasm
Cytoplasm
Golgi Apparatus
Intracellular Membrane-bounded Organelle
Molecular Function
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Cyclin Binding
Poly(A) RNA Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Positive Regulation Of Cell-matrix Adhesion
Type B Pancreatic Cell Development
Protein Phosphorylation
Cell Cycle Arrest
Notch Signaling Pathway
Negative Regulation Of Cell Proliferation
Response To Virus
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Astrocyte Development
Dentate Gyrus Development
Lateral Ventricle Development
T Cell Differentiation In Thymus
Gliogenesis
Cell Dedifferentiation
Negative Regulation Of Cell Differentiation
Negative Regulation Of Myeloid Cell Differentiation
Regulation Of Erythrocyte Differentiation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of Fibroblast Proliferation
Generation Of Neurons
Negative Regulation Of Epithelial Cell Proliferation
Cell Division
Hematopoietic Stem Cell Differentiation
Regulation Of Cell Motility
Negative Regulation Of Cellular Senescence
Keratinization
Pathways
Cyclin D associated events in G1
Oxidative Stress Induced Senescence
G1 Phase
Cellular Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Mitotic G1-G1/S phases
Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Height (
20881960
19343178
23563607
18391950
18391951
18391952
)
Rheumatoid arthritis (
18794853
)
White blood cell count (
20139978
21738479
)
White blood cell types (
21738478
)
Protein-Protein Interactions
92 interactors:
ABI2
ANKRD12
AR
ATF6B
ATXN1
BCL11A
CASC3
CBY1
CCND1
CCND3
CDC37
CDC6
CDK7
CDKN1A
CDKN2A
CDKN2B
CDKN2C
CDKN2D
CLASRP
CNOT7
CTNNB1
DAB1
DDIT3
DEDD2
EBF4
EIF4ENIF1
ELK1
EZH2
FOXM1
FOXO3
HIST1H1A
HSF1
ISL1
KIF26B
KLF10
LPIN1
MCM10
MCM2
MEF2D
MLLT3
MSL3
MYC
MZF1
N4BP1
NFATC3
NIPBL
NUMA1
PCNA
PML
POGZ
PPARGC1A
PPHLN1
PPM1B
PPP2CA
PRX
PSMA3
RB1
RBL1
RBL2
RBM23
RUNX1
SENP3
SIRT1
SLBP
SNIP1
SORBS1
SOX10
SOX5
SRSF1
SRSF11
SRSF12
SRSF2
SRSF7
SSBP2
SYNPO2
TCEB3B
TFDP1
TGFBR1
TJP2
TPX2
TRA2A
TRA2B
TRAK1
UHRF2
VGLL4
ZEB1
ZFP36
ZMYM3
ZNF101
ZNF174
ZNF335
ZSCAN1
20 interactors:
APP
BCL2L1
BRCA1
CASP5
CCDC57
CDC37
CDK6
MTUS2
NAGK
PAXIP1
PPL
SEPT8
SNCAIP
SQSTM1
TGM2
TOMM20
TP53BP2
TSGA10
UFD1L
VIM
Entrez ID
1021
51535
HPRD ID
04533
10488
Ensembl ID
ENSG00000105810
ENSG00000134283
Uniprot IDs
A4D1G0
Q00534
B7Z8L1
E9PAX8
F8W6A0
Q8NEY8
PDB IDs
1BI7
1BI8
1BLX
1G3N
1JOW
1XO2
2EUF
2F2C
3NUP
3NUX
4AUA
4EZ5
Enriched GO Terms of Interacting Partners
?
RNA Metabolic Process
Gene Expression
Transcription, DNA-templated
RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Cell Cycle
Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Cell Cycle Process
Positive Regulation Of Cellular Biosynthetic Process
Mitotic Cell Cycle
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Cell Cycle
Mitotic Cell Cycle Process
Regulation Of Phosphorylation
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cellular Protein Metabolic Process
Regulation Of Phosphorus Metabolic Process
Cellular Metabolic Process
RNA Processing
Regulation Of Protein Metabolic Process
Regulation Of Cellular Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Response To Ionizing Radiation
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Response To Radiation
Positive Regulation Of Histone H3-K4 Methylation
Regulation Of Cell Cycle
Positive Regulation Of Histone Acetylation
Signal Transduction By P53 Class Mediator
Developmental Process
Regulation Of Histone H3-K4 Methylation
Response To Abiotic Stimulus
Positive Regulation Of Peptidyl-lysine Acetylation
Apoptotic Signaling Pathway
Organ Development
Positive Regulation Of Protein Acetylation
Astrocyte Development
Multicellular Organismal Development
Anatomical Structure Development
System Development
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Cell Cycle
Positive Regulation Of Histone Methylation
Intrinsic Apoptotic Signaling Pathway
Intracellular Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Astrocyte Differentiation
Regulation Of Histone Acetylation
Central Nervous System Development
Positive Regulation Of Gene Expression
Regulation Of Histone Methylation
Neuron Apoptotic Process
Positive Regulation Of Histone H4-K20 Methylation
Cell Dedifferentiation
Positive Regulation Of Histone H3-K36 Methylation
Positive Regulation Of Histone H4-K16 Acetylation
Apoptotic Process In Bone Marrow
Regulation Of Signaling
Neuron Death
Positive Regulation Of Histone Modification
Execution Phase Of Apoptosis
Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine
Synaptic Growth At Neuromuscular Junction
Positive Regulation Of Histone H3-K9 Acetylation
N-acetylmannosamine Metabolic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Cell Differentiation
Cellular Protein Metabolic Process
Signal Transduction In Response To DNA Damage
Tagcloud
?
a134c
abp
allelic
ankyrin
balb
cdkn2a
cdkn2b
cdkn2c
cdnas
chr
congenic
d2
dba
g232a
ifna
inbred
inefficient
ink4c
le
multigenic
mus
p15
p16
p18
pctr1
plasmacytoma
pristane
spretus
typed
Tagcloud (Difference)
?
a134c
abp
allelic
ankyrin
balb
cdkn2a
cdkn2b
cdkn2c
cdnas
chr
congenic
d2
dba
g232a
ifna
inbred
inefficient
ink4c
le
multigenic
mus
p15
p16
p18
pctr1
plasmacytoma
pristane
spretus
typed
Tagcloud (Intersection)
?