CDK6 and TPX2

Number of citations of the paper that reports this interaction (PMID 22094256)
37

Data Source:
BioGRID (enzymatic study)

		CDK6	TPX2
Gene Name		cyclin-dependent kinase 6	TPX2, microtubule-associated
Image
Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol	Spindle Pole Nucleus Nucleoplasm Cytoplasm Spindle Microtubule Microtubule Cytoskeleton Axon Hillock
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin Binding	Protein Binding ATP Binding GTP Binding Protein Kinase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Positive Regulation Of Cell-matrix Adhesion Type B Pancreatic Cell Development Protein Phosphorylation Cell Cycle Arrest Notch Signaling Pathway Negative Regulation Of Cell Proliferation Response To Virus Regulation Of Gene Expression Positive Regulation Of Gene Expression Astrocyte Development Dentate Gyrus Development Lateral Ventricle Development T Cell Differentiation In Thymus Gliogenesis Cell Dedifferentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Cell Division Hematopoietic Stem Cell Differentiation Regulation Of Cell Motility Negative Regulation Of Cellular Senescence	Apoptotic Process Mitotic Nuclear Division Cell Proliferation Activation Of Protein Kinase Activity Cell Division Regulation Of Mitotic Spindle Organization
Pathways		Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Height ( 20881960 19343178 23563607 18391950 18391951 18391952) Rheumatoid arthritis ( 18794853) White blood cell count ( 20139978 21738479) White blood cell types ( 21738478)
Protein-Protein Interactions		92 interactors: ABI2 ANKRD12 AR ATF6B ATXN1 BCL11A CASC3 CBY1 CCND1 CCND3 CDC37 CDC6 CDK7 CDKN1A CDKN2A CDKN2B CDKN2C CDKN2D CLASRP CNOT7 CTNNB1 DAB1 DDIT3 DEDD2 EBF4 EIF4ENIF1 ELK1 EZH2 FOXM1 FOXO3 HIST1H1A HSF1 ISL1 KIF26B KLF10 LPIN1 MCM10 MCM2 MEF2D MLLT3 MSL3 MYC MZF1 N4BP1 NFATC3 NIPBL NUMA1 PCNA PML POGZ PPARGC1A PPHLN1 PPM1B PPP2CA PRX PSMA3 RB1 RBL1 RBL2 RBM23 RUNX1 SENP3 SIRT1 SLBP SNIP1 SORBS1 SOX10 SOX5 SRSF1 SRSF11 SRSF12 SRSF2 SRSF7 SSBP2 SYNPO2 TCEB3B TFDP1 TGFBR1 TJP2 TPX2 TRA2A TRA2B TRAK1 UHRF2 VGLL4 ZEB1 ZFP36 ZMYM3 ZNF101 ZNF174 ZNF335 ZSCAN1	7 interactors: AURKA CDK6 GOLGA2 HMMR NAP1L1 SIAH2 THAP11
Entrez ID		1021	22974
HPRD ID		04533	05802
Ensembl ID		ENSG00000105810	ENSG00000088325
Uniprot IDs		A4D1G0 Q00534	Q643R0 Q96RR5 Q9ULW0
PDB IDs		1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX 4AUA 4EZ5	1OL5 3E5A 3HA6
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Cell Cycle Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cell Cycle Process Positive Regulation Of Cellular Biosynthetic Process Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Metabolic Process RNA Processing Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Protein Binding Negative Regulation Of Spindle Checkpoint Cell Dedifferentiation Cell Cycle Negative Regulation Of Binding Spindle Assembly Involved In Female Meiosis I Regulation Of Protein Binding Spindle Assembly Involved In Meiosis Mitotic Cell Cycle Spindle Stabilization Positive Regulation Of Oocyte Maturation Regulation Of Binding Mitotic Cell Cycle Phase Transition Meiotic Spindle Organization Cell Cycle Phase Transition Protein Localization To Centrosome Mitotic Centrosome Separation Negative Regulation Of Cellular Senescence Female Meiosis I Positive Regulation Of Oocyte Development Centrosome Separation Hematopoietic Stem Cell Differentiation Hyaluronan Catabolic Process Negative Regulation Of Cell Aging Dentate Gyrus Development Protein Localization To Cytoskeleton Histone-serine Phosphorylation Type B Pancreatic Cell Development
Tagcloud ?		a134c abp allelic ankyrin balb cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	actively autonomous clustering connected connectivity conserved degree displaying disseminated distant dormant enhances enriched etiology histologic identification inferred instead metastasis metastatic modules network networks proliferating tool transition utilized validate variation
Tagcloud (Difference) ?		a134c abp allelic ankyrin balb cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	actively autonomous clustering connected connectivity conserved degree displaying disseminated distant dormant enhances enriched etiology histologic identification inferred instead metastasis metastatic modules network networks proliferating tool transition utilized validate variation
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