CDK6 and N4BP1

Number of citations of the paper that reports this interaction (PMID 22094256)
37

Data Source:
BioGRID (enzymatic study)

		CDK6	N4BP1
Gene Name		cyclin-dependent kinase 6	NEDD4 binding protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleolus PML Body
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Positive Regulation Of Cell-matrix Adhesion Type B Pancreatic Cell Development Protein Phosphorylation Cell Cycle Arrest Notch Signaling Pathway Negative Regulation Of Cell Proliferation Response To Virus Regulation Of Gene Expression Positive Regulation Of Gene Expression Astrocyte Development Dentate Gyrus Development Lateral Ventricle Development T Cell Differentiation In Thymus Gliogenesis Cell Dedifferentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Cell Division Hematopoietic Stem Cell Differentiation Regulation Of Cell Motility Negative Regulation Of Cellular Senescence	Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV
Pathways		Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Height ( 20881960 19343178 23563607 18391950 18391951 18391952) Rheumatoid arthritis ( 18794853) White blood cell count ( 20139978 21738479) White blood cell types ( 21738478)
Protein-Protein Interactions		92 interactors: ABI2 ANKRD12 AR ATF6B ATXN1 BCL11A CASC3 CBY1 CCND1 CCND3 CDC37 CDC6 CDK7 CDKN1A CDKN2A CDKN2B CDKN2C CDKN2D CLASRP CNOT7 CTNNB1 DAB1 DDIT3 DEDD2 EBF4 EIF4ENIF1 ELK1 EZH2 FOXM1 FOXO3 HIST1H1A HSF1 ISL1 KIF26B KLF10 LPIN1 MCM10 MCM2 MEF2D MLLT3 MSL3 MYC MZF1 N4BP1 NFATC3 NIPBL NUMA1 PCNA PML POGZ PPARGC1A PPHLN1 PPM1B PPP2CA PRX PSMA3 RB1 RBL1 RBL2 RBM23 RUNX1 SENP3 SIRT1 SLBP SNIP1 SORBS1 SOX10 SOX5 SRSF1 SRSF11 SRSF12 SRSF2 SRSF7 SSBP2 SYNPO2 TCEB3B TFDP1 TGFBR1 TJP2 TPX2 TRA2A TRA2B TRAK1 UHRF2 VGLL4 ZEB1 ZFP36 ZMYM3 ZNF101 ZNF174 ZNF335 ZSCAN1	5 interactors: AZI2 CDK6 ITCH LSM1 UBC
Entrez ID		1021	9683
HPRD ID		04533
Ensembl ID		ENSG00000105810	ENSG00000102921
Uniprot IDs		A4D1G0 Q00534	O75113
PDB IDs		1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX 4AUA 4EZ5
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Cell Cycle Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cell Cycle Process Positive Regulation Of Cellular Biosynthetic Process Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Metabolic Process RNA Processing Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter	Notch Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production I-kappaB Kinase/NF-kappaB Signaling Regulation Of Type I Interferon Production Tumor Necrosis Factor Production Cell Dedifferentiation Mitotic Cell Cycle Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Immune System Process Activation Of Innate Immune Response G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Protein Polyubiquitination Positive Regulation Of Innate Immune Response Interferon-alpha Production Viral Life Cycle Intracellular Receptor Signaling Pathway Negative Regulation Of Cytokine Production Interleukin-6 Production Positive Regulation Of Protein Catabolic Process Dendritic Cell Proliferation Protein K29-linked Ubiquitination Regulation Of Innate Immune Response Regulation Of Protein Deubiquitination Positive Regulation Of T Cell Anergy Mitotic Cell Cycle Phase Transition Response To Virus Cell Cycle Phase Transition T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Regulation Of Immune System Process Cell Cycle Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Leukocyte Cell-cell Adhesion Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Homotypic Cell-cell Adhesion Leukocyte Differentiation Negative Regulation Of Alpha-beta T Cell Proliferation Regulation Of T Cell Anergy Histone MRNA Catabolic Process Negative Regulation Of Cellular Senescence Viral Protein Processing Negative Regulation Of Immune System Process Positive Regulation Of T Cell Tolerance Induction Regulation Of Protein Catabolic Process
Tagcloud ?		a134c abp allelic ankyrin balb cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	carp cdna cik cloned close ctenopharyngodon e3 encoded frame gcrv gill grass head homology idella interacting kh latipes ligase limit nedd4 nyn orf oryzias reading reovirus spleen
Tagcloud (Difference) ?		a134c abp allelic ankyrin balb cdkn2a cdkn2b cdkn2c cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	carp cdna cik cloned close ctenopharyngodon e3 encoded frame gcrv gill grass head homology idella interacting kh latipes ligase limit nedd4 nyn orf oryzias reading reovirus spleen
Tagcloud (Intersection) ?