CDK6 and EIF4ENIF1

Number of citations of the paper that reports this interaction (PubMedID 22094256)
37

Data Source:
BioGRID (enzymatic study)

		CDK6	EIF4ENIF1
Description		cyclin dependent kinase 6	eukaryotic translation initiation factor 4E nuclear import factor 1
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Ruffle Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cell Projection Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex Cyclin D3-CDK6 Complex	P-body Nucleus Cytoplasm Cytosol Membrane PML Body Nuclear Speck Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cyclin Binding FBXO Family Protein Binding Protein Serine Kinase Activity	RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Protein Binding Kinase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell-matrix Adhesion Hematopoietic Progenitor Cell Differentiation Type B Pancreatic Cell Development DNA Damage Response Signal Transduction Notch Signaling Pathway Negative Regulation Of Cell Population Proliferation Response To Virus Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Positive Regulation Of Gene Expression Astrocyte Development Dentate Gyrus Development Lateral Ventricle Development Hemopoiesis Cell Differentiation T Cell Differentiation In Thymus Gliogenesis Regulation Of Cell Population Proliferation Cell Dedifferentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Cell Division Regulation Of Cell Cycle Hematopoietic Stem Cell Differentiation Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Cell Motility Negative Regulation Of Cellular Senescence	Translation Regulation Of Translation Protein Import Into Nucleus Protein Transport Negative Regulation Of Translation Stem Cell Population Maintenance Neuron Differentiation Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Neuron Differentiation MRNA Stabilization Nuclear Export Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
Pathways		Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity
Drugs		Alvocidib (2S)-2-({6-[(3-Amino-5-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methyl-1-butanol Fisetin Palbociclib Ribociclib Abemaciclib Trilaciclib
Diseases
GWAS		Alanine aminotransferase levels ( 34315874 33547301) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874) Atrial fibrillation ( 29892015 30061737) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30578418) Eosinophil count ( 32888494 27863252 29403010) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Height ( 31562340 18391951 28552196 25282103 18391950 18391952 19343178 20881960 23563607) Hip circumference adjusted for BMI ( 25673412 34021172 28552196) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 29403010 25096241 32888494 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418 27618447 27841878) Red blood cell count ( 29403010 32888494) Rheumatoid arthritis ( 18794853 24390342 30423114) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 27841878 30578418) Total cholesterol levels ( 30275531) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172) Weight ( 28552196) White blood cell count ( 25096241 21738479 20139978 29403010 32888494 27863252) White blood cell count (basophil) ( 27863252) White blood cell types ( 21738478)	Age-related hearing impairment ( 24939585) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663)
Interacting Genes		137 interacting genes: ABI2 AKT1 ANKRD12 APOBEC1 AR ARAF ARNT ATF6B ATXN1 BCL11A BECN1 CASC3 CBLC CBY1 CCND1 CCND2 CCND3 CCNE1 CCNH CCNI CD44 CDC37 CDC6 CDK7 CDKN1A CDKN2A CDKN2B CDKN2C CDKN2D CLASRP CNOT7 CTNNB1 DDIT3 DEDD2 EBF4 EIF4ENIF1 ELK1 ELOA2 EPHA2 ERBB2 EZH2 FARP2 FGFR4 FOXM1 FOXO3 FZR1 GLIS1 GLIS2 GRM1 H1-1 HGF HIF1A HSF1 ISL1 KAT2A KDELR2 KEAP1 KIF26B KLF10 LATS2 LPIN1 MAP2K3 MAP2K5 MAP3K5 MAPK14 MCM10 MCM2 MEF2D MET MLLT3 MSL3 MYC MZF1 N4BP1 NF2 NFATC3 NIPBL NUMA1 OTP PCNA PDGFRA PML POGZ PPARGC1A PPHLN1 PPM1B PPP2CA PRX PSMA3 RAF1 RASSF1 RB1 RBL1 RBL2 RBM23 RBPMS RUNX1 SENP3 SIRT1 SLBP SNIP1 SORBS1 SOX10 SOX5 SRSF1 SRSF11 SRSF12 SRSF2 SRSF7 SSBP2 STK11 SUMO1 SYNPO2 TEAD2 TERT TFDP1 TGFBR1 TJP2 TNFRSF1A TP53 TPX2 TRA2A TRA2B TRAK1 TRIM15 TSC1 UHRF2 USP17L2 USP51 VGLL4 ZEB1 ZFP36 ZMYM3 ZNF101 ZNF174 ZNF335 ZSCAN1	92 interacting genes: ALG13 ANKHD1 ANXA2 ATP5F1B ATXN1 BAG4 BCAS2 BYSL CDK6 CFAP206 CLASP1 CLK3 CPSF7 CTNNA1 CUL1 DAPK1 DDX1 DDX11 DDX28 DEF6 DHX37 DHX57 DST DTX2 EEF1G EFHC1 EHMT2 EIF3E EIF4E EIF4E2 ELAVL3 EXOSC7 FANCL FDPS FTSJ3 GOLGA4 HDGF HNRNPF HNRNPLL HOOK3 HSPA1A KPNA2 KRT19 KRT31 L3MBTL2 LLPH LMNA LUC7L MGAT5B MYO10 NOP9 NXF3 OIP5 PKP2 PNKP POLR2A PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAE1 RBBP6 RBFOX2 RBM22 RNF10 RPL15 RPL19 RPL26 RPL31 RPRD1B RPS21 RPS6 RPS7 SF3B3 SMAD3 SNRNP40 SNRPN SPAG5 SRBD1 SRSF8 SUPV3L1 TCHP TRAK2 TTC19 TUBA1A TXLNA USP2 WBP4 WTAP XRCC6
Entrez ID		1021	56478
HPRD ID		04533	10456
Ensembl ID		ENSG00000105810	ENSG00000184708
Uniprot IDs		Q00534	Q9NRA8
PDB IDs		1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX 4AUA 4EZ5 4TTH 5L2I 5L2S 5L2T 6OQL 6OQO 8I0M	5ANR 6F9W 6X2R
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Animal Organ Development Regulation Of Cell Differentiation Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Developmental Process Negative Regulation Of Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction Macromolecule Metabolic Process Response To Growth Factor Negative Regulation Of Signal Transduction DNA Binding Cell Population Proliferation	RNA Binding RNA Processing MRNA Metabolic Process RNA Metabolic Process Nucleic Acid Metabolic Process Nucleic Acid Binding Nucleoplasm Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Processing Regulation Of RNA Splicing Nucleus Nucleolus Cytosolic Ribosome Ribonucleoprotein Complex Cytoplasm Translation RNA Splicing Structural Constituent Of Ribosome RRNA Processing Nuclear Speck Cytoplasmic Translation Helicase Activity RRNA Metabolic Process Catalytic Step 2 Spliceosome Centrosome MRNA Splicing, Via Spliceosome Protein Binding RNA Splicing, Via Transesterification Reactions Macromolecule Biosynthetic Process Cytoskeleton Preribosome, Small Subunit Precursor Ribonucleoprotein Complex Biogenesis RNA Helicase Activity Prp19 Complex Spliceosomal Complex MRNA Binding Ribosome Positive Regulation Of RNA Splicing RNA 3'-end Processing Regulation Of Neurogenesis Microtubule Cytoskeleton Organization MRNA Cap Binding Ubiquitin Protein Ligase Binding Cytosolic Large Ribosomal Subunit Microtubule Plus-end Microtubule Anchoring Chromosome Cytosol Structural Molecule Activity
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