RECQL4 and TERF2IP

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		RECQL4	TERF2IP
Gene Name		RecQ protein-like 4	telomeric repeat binding factor 2, interacting protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Membrane	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mre11 Complex
	Molecular Function	Bubble DNA Binding ATP Binding Zinc Ion Binding Annealing Helicase Activity ATP-dependent 3'-5' DNA Helicase Activity	Protein Binding Telomeric DNA Binding
	Biological Process	DNA Strand Renaturation DNA Replication DNA Repair DNA Recombination Multicellular Organismal Development DNA Duplex Unwinding	Telomere Maintenance Transcription, DNA-templated Regulation Of Transcription, DNA-templated Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Protection From Non-homologous End Joining At Telomere Negative Regulation Of Telomere Maintenance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region
Pathways			Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ACD EP300 POT1 PRSS23 TERF1 TERF2IP	125 interactors: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 C9orf78 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DHX38 DNMT3A DPP3 ENAH EPAS1 EPS8L1 FABP2 FAM122A GAGE5 GAMT GNMT GPKOW HAAO HAGH HDGFRP3 HIST1H1A HIST1H2AL HIST1H4B HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NUDT14 NUDT18 NUMA1 NXNL1 OCM2 OGFR PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PML PNMT POLD1 PPM1G PPP1R2 PPP6R3 PRDX6 PRX PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SMARCC2 SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 XRCC6 ZNF146 ZNF414
Entrez ID		9401	54386
HPRD ID		04805	05452
Ensembl ID		ENSG00000160957	ENSG00000166848
Uniprot IDs		O94761	Q9NYB0
PDB IDs		2KMU	1FEX 3K6G
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Regulation Of Telomerase Activity Negative Regulation Of DNA Metabolic Process RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Telomere Assembly Protection From Non-homologous End Joining At Telomere Protein Localization To Chromosome, Telomeric Region Chromosome Organization Positive Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Regulation Of DNA Replication Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Protein Localization To Chromosome DNA Replication Negative Regulation Of Cellular Metabolic Process Regulation Of Organelle Organization DNA Metabolic Process Positive Regulation Of DNA Replication Negative Regulation Of Biosynthetic Process Homeostatic Process Organelle Organization Histone H2B Acetylation Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Segmentation G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Binding Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of DNA Metabolic Process Regulation Of Cellular Component Organization Telomeric Loop Formation Age-dependent Telomere Shortening N-terminal Peptidyl-lysine Acetylation Telomere Formation Via Telomerase Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomere Shortening Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response	Chromosome Organization Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Organelle Organization Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process DNA Conformation Change Chromatin Modification Cell Cycle Cellular Response To Stress DNA Metabolic Process Cellular Response To DNA Damage Stimulus Sequestering Of Actin Monomers DNA Recombination Telomere Maintenance Via Telomere Lengthening Catabolic Process DNA Duplex Unwinding Cellular Aldehyde Metabolic Process Cellular Hyperosmotic Salinity Response DNA Geometric Change DNA Replication Energy Reserve Metabolic Process Nucleosome Organization Organophosphate Catabolic Process Response To Stress Chromatin Assembly Or Disassembly Deoxyribose Phosphate Catabolic Process Cellular Localization Cellular Metabolic Process Protein Localization To Nucleus Glycogen Metabolic Process Nucleocytoplasmic Transport Chromatin Remodeling Base-excision Repair Cellular Response To X-ray Nuclear Transport Aromatic Compound Catabolic Process Nucleosome Assembly Deoxyribonucleotide Catabolic Process DNA Strand Elongation Involved In DNA Replication Small Molecule Metabolic Process DNA Strand Elongation Biosynthetic Process Chromatin Assembly Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Transport Energy Derivation By Oxidation Of Organic Compounds
Tagcloud ?		baller col2a1 conditional copyright craniofacial craniosynostosis cre developmental fl gerold helicases inactivation limb mimicking plate protected prx1 radial rapadilino rescue reserved rights rothmund skeletal thomson transgene trp53	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates
Tagcloud (Difference) ?		baller col2a1 conditional copyright craniofacial craniosynostosis cre developmental fl gerold helicases inactivation limb mimicking plate protected prx1 radial rapadilino rescue reserved rights rothmund skeletal thomson transgene trp53	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates
Tagcloud (Intersection) ?