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RECQL4 and TOMM20
Number of citations of the paper that reports this interaction (PubMedID
37495109
)
47
Data Source:
BioGRID
(pull down, affinity chromatography technology)
RECQL4
TOMM20
Description
RecQ like helicase 4
translocase of outer mitochondrial membrane 20
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Membrane
Mitochondrion
Mitochondrial Envelope
Mitochondrial Outer Membrane
Mitochondrial Outer Membrane Translocase Complex
Membrane
Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site
Cell Periphery
Sperm Midpiece
Migrasome
TOM Complex
Molecular Function
Nucleotide Binding
Bubble DNA Binding
Nucleic Acid Binding
DNA Binding
Helicase Activity
Protein Binding
ATP Binding
Four-way Junction Helicase Activity
Hydrolase Activity
Isomerase Activity
ATP Hydrolysis Activity
Oxidized Purine DNA Binding
3'-5' DNA Helicase Activity
Metal Ion Binding
Telomeric D-loop Binding
Catalytic Activity, Acting On DNA
DNA/DNA Annealing Activity
Protein Binding
Protein Transmembrane Transporter Activity
Protein-transporting ATPase Activity
Mitochondrion Targeting Sequence Binding
Unfolded Protein Binding
Biological Process
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
DNA Repair
DNA Recombination
Chromosome Organization
Telomeric D-loop Disassembly
Protein Targeting
Protein Targeting To Mitochondrion
Intracellular Protein Transport
Protein Transport
TRNA Import Into Mitochondrion
Protein Import Into Mitochondrial Matrix
Protein Insertion Into Mitochondrial Outer Membrane
Pathways
Mitochondrial protein import
PINK1-PRKN Mediated Mitophagy
Ub-specific processing proteases
Drugs
Diseases
RAPADILINO syndrome
Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
GWAS
Age at first birth (
27798627
)
Educational attainment (
25201988
)
General cognitive ability (
29844566
)
Apolipoprotein A1 levels (
32203549
)
Cholesterol, total (
20686565
)
Cobalt levels (
26025379
)
Immune reponse to smallpox (secreted IL-2) (
22610502
)
LDL cholesterol (
20686565
)
LDL cholesterol levels (
32203549
)
Night sleep phenotypes (
27126917
)
Obesity-related traits (
23251661
)
Serum alkaline phosphatase levels (
33547301
)
Interacting Genes
11 interacting genes:
ACD
EP300
MARCHF5
MCM10
POT1
PRSS23
RNF8
TERF1
TERF2IP
TOMM20
WRAP53
22 interacting genes:
AIP
APOA1
ATXN1
BAG6
BCL2
CDC73
CEP126
DHFR
FBXO7
FEZ1
HAP1
HSD17B10
OTC
PINK1
PPHLN1
PTN
RECQL4
SNCA
TOMM22
UCP1
USP40
VDAC1
Entrez ID
9401
9804
HPRD ID
04805
03507
Ensembl ID
ENSG00000160957
ENSG00000173726
Uniprot IDs
A0A087X072
O94761
Q15388
PDB IDs
2KMU
5LST
4APO
7VBY
7VC9
8XVA
9EIH
9EII
9EIJ
Enriched GO Terms of Interacting Partners
?
Telomere Maintenance Via Telomerase
Shelterin Complex
RNA-templated DNA Biosynthetic Process
Telomere Maintenance Via Telomere Lengthening
Nuclear Telomere Cap Complex
Telomere Capping
Positive Regulation Of Telomere Maintenance
Chromosome, Telomeric Region
Telomere Assembly
DNA Biosynthetic Process
Telomeric DNA Binding
Telomere Maintenance
Regulation Of Establishment Of Protein Localization To Telomere
Positive Regulation Of Chromosome Organization
Regulation Of Telomere Maintenance
Regulation Of Establishment Of Protein Localization To Chromosome
Negative Regulation Of Telomere Maintenance
Positive Regulation Of DNA Metabolic Process
Telomere Organization
Regulation Of Telomere Maintenance Via Telomerase
G-rich Strand Telomeric DNA Binding
Regulation Of Telomere Maintenance Via Telomere Lengthening
Protein Localization To Organelle
Chromosome
DNA Metabolic Process
Negative Regulation Of Chromosome Organization
Regulation Of DNA Biosynthetic Process
Negative Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Chromosome Organization
Regulation Of DNA Metabolic Process
Positive Regulation Of Organelle Organization
Protein Localization To Chromosome
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of DNA Biosynthetic Process
Negative Regulation Of DNA Metabolic Process
Chromosome Organization
Regulation Of Double-strand Break Repair
Positive Regulation Of Cellular Component Organization
Regulation Of Organelle Organization
DNA Damage Response
Telomerase Inhibitor Activity
Establishment Of Protein Localization To Telomere
Protection From Non-homologous End Joining At Telomere
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Biosynthetic Process
Regulation Of DNA Repair
Telomeric D-loop Disassembly
Regulation Of Cellular Response To Stress
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Protein Stability
Mitochondrion Organization
Regulation Of Reactive Oxygen Species Metabolic Process
Mitochondrion
Establishment Of Protein Localization To Mitochondrion
Mitochondrial Outer Membrane
Neuron Projection Regeneration
Regulation Of Autophagy
Positive Regulation Of Mitophagy
Positive Regulation Of Autophagy Of Mitochondrion
Protein Targeting
Protein Targeting To Mitochondrion
Negative Regulation Of Autophagy
Mitochondrial Transport
Growth Cone
Regulation Of Mitophagy
Regulation Of Calcium Ion Transmembrane Transport
Negative Regulation Of Metabolic Process
Regulation Of Autophagy Of Mitochondrion
Negative Regulation Of Neuron Apoptotic Process
Establishment Of Protein Localization To Organelle
Regulation Of Organelle Transport Along Microtubule
Negative Regulation Of Apoptotic Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Type 2 Mitophagy
Negative Regulation Of Catabolic Process
Regulation Of Macroautophagy
Negative Regulation Of Autophagosome Assembly
Pore Complex
Regulation Of Biological Quality
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Regulation Of Calcium Ion Transport
Regulation Of Hydrogen Peroxide Metabolic Process
Inclusion Body
Positive Regulation Of Macroautophagy
Regulation Of Neuron Apoptotic Process
Axon Regeneration
Regulation Of Monoatomic Cation Transmembrane Transport
Regulation Of Cellular Response To Oxidative Stress
Dopamine Transport
Regulation Of Oxidative Phosphorylation
Mitochondrial Transmembrane Transport
Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Mitochondrial Membrane Organization
Cellular Localization
Regulation Of Dopamine Secretion
Establishment Of Localization In Cell
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