RECQL4 and PRSS23

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RECQL4	PRSS23
Description		RecQ like helicase 4	serine protease 23
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Membrane	Extracellular Region Nucleus Endoplasmic Reticulum Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding Bubble DNA Binding Nucleic Acid Binding DNA Binding Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Oxidized Purine DNA Binding 3'-5' DNA Helicase Activity Metal Ion Binding Telomeric D-loop Binding Catalytic Activity, Acting On DNA DNA/DNA Annealing Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair DNA Recombination Chromosome Organization Telomeric D-loop Disassembly	Proteolysis
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases		RAPADILINO syndrome Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
GWAS		Age at first birth ( 27798627) Educational attainment ( 25201988) General cognitive ability ( 29844566)	Blood urea nitrogen levels ( 31152163) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Heel bone mineral density ( 28869591 30598549) Intraocular pressure ( 29617998 29785010) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		11 interacting genes: ACD EP300 MARCHF5 MCM10 POT1 PRSS23 RNF8 TERF1 TERF2IP TOMM20 WRAP53	27 interacting genes: ACTG1 APP B2M CHP1 EFNA3 FXR1 GATD1 GRK6 HSPA4 MAPK8IP2 NCAPD3 NIPBL NOC4L ODF2L PDPK1 PHF23 PPIA RACGAP1 RECQL4 RPL4P5 SEC11C SHMT1 SLC25A6 TCF12 TMEM222 TRAPPC4 UBC
Entrez ID		9401	11098
HPRD ID		04805	07149
Ensembl ID		ENSG00000160957	ENSG00000150687
Uniprot IDs		A0A087X072 O94761	O95084
PDB IDs		2KMU 5LST
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomerase Shelterin Complex RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Nuclear Telomere Cap Complex Telomere Capping Positive Regulation Of Telomere Maintenance Chromosome, Telomeric Region Telomere Assembly DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Establishment Of Protein Localization To Chromosome Negative Regulation Of Telomere Maintenance Positive Regulation Of DNA Metabolic Process Telomere Organization Regulation Of Telomere Maintenance Via Telomerase G-rich Strand Telomeric DNA Binding Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Localization To Organelle Chromosome DNA Metabolic Process Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Protein Localization To Chromosome Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Metabolic Process Chromosome Organization Regulation Of Double-strand Break Repair Positive Regulation Of Cellular Component Organization Regulation Of Organelle Organization DNA Damage Response Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Protection From Non-homologous End Joining At Telomere Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA Repair Telomeric D-loop Disassembly Regulation Of Cellular Response To Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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