SLC9A3R1 and RDX

Number of citations of the paper that reports this interaction (PMID 9430655)
44

Data Source:
HPRD (in vivo, in vitro)

		SLC9A3R1	RDX
Gene Name		solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	radixin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Centrosome Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome Cell Periphery Sperm Midpiece	Ruffle Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Extrinsic Component Of Membrane Lamellipodium Filopodium T-tubule Cleavage Furrow Stereocilium Apical Part Of Cell Cell Tip Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Self-association Dopamine Receptor Binding Growth Factor Receptor Binding	Actin Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Renal Sodium Ion Transport Protein Complex Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Cellular Protein Localization Glutathione Transport Regulation Of Excretion Regulation Of Protein Kinase Activity Negative Regulation Of Protein Kinase B Signaling Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Positive Regulation Of Gene Expression Microvillus Assembly Apical Protein Localization Actin Filament Capping Establishment Of Endothelial Barrier
Pathways			Axon guidance L1CAM interactions Recycling pathway of L1
Drugs
Diseases
GWAS		Fibrinogen ( 20031577)
Protein-Protein Interactions		52 interactors: ABCC2 ABCC4 ADRB2 AKAP10 ATP6V1B1 ATP6V1E1 BCL10 CFTR CLCN3 CNGA2 CTNNB1 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PIK3CA PLCB1 PLCB2 PTEN PTH1R RDX RLBP1 SCN4A SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468	16 interactors: ABCC2 ARHGDIA CALM1 CPNE1 CPNE2 CPNE4 DRD3 EZR GNA13 ICAM2 ITGB2 L1CAM ROCK1 SLC9A3R1 SLC9A3R2 TSC1
Entrez ID		9368	5962
HPRD ID		05406	01534
Ensembl ID		ENSG00000109062	ENSG00000137710
Uniprot IDs		O14745	B0YJ88 P35241 Q6PKD3
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF
Enriched GO Terms of Interacting Partners?		Ion Homeostasis Ion Transmembrane Transport Transmembrane Transport Homeostatic Process Ion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Chemical Homeostasis Cellular Ion Homeostasis Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of PH Response To Organonitrogen Compound Cellular Chemical Homeostasis Monocarboxylic Acid Transport Positive Regulation Of Phospholipase Activity Transport Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Vasodilation Regulation Of Phosphorus Metabolic Process Cellular Response To Organonitrogen Compound Response To Stimulus Inorganic Anion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Cell Development Response To External Stimulus Monovalent Inorganic Cation Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Metal Ion Transport Cellular Homeostasis Establishment Of Endothelial Barrier Regulation Of Ion Transmembrane Transport Blood Coagulation Response To Estrogen Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Hemostasis Regulation Of Body Fluid Levels Signaling Wound Healing Response To Organic Substance Response To Hormone Cell Surface Receptor Signaling Pathway Cell Communication Cation Transport Positive Regulation Of Inositol Phosphate Biosynthetic Process	Membrane To Membrane Docking Cellular Extravasation Negative Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Transporter Activity Negative Regulation Of Ion Transmembrane Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Transmembrane Transport Rho Protein Signal Transduction Negative Regulation Of Sodium Ion Transmembrane Transport Single Organismal Cell-cell Adhesion Cellular Chemical Homeostasis Cell Surface Receptor Signaling Pathway Membrane Docking Negative Regulation Of Ion Transport Negative Regulation Of Sodium Ion Transport Regulation Of Proton Transport Leukocyte Cell-cell Adhesion Leukocyte Tethering Or Rolling Regulation Of Locomotion Cell Adhesion Cellular Homeostasis Microvillus Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Microvillus Organization Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Cellular Component Organization Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Monocarboxylic Acid Transport Regulation Of Ion Transmembrane Transporter Activity Response To Organonitrogen Compound Regulation Of Transmembrane Transporter Activity Negative Regulation Of Intracellular Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Regulation Of Excretion Chemical Homeostasis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Regulation Of Cell Shape Cell-matrix Adhesion Cellular Ion Homeostasis Movement Of Cell Or Subcellular Component Regulation Of Cell Morphogenesis Regulation Of Sodium Ion Transmembrane Transporter Activity Nervous System Development Response To Amphetamine Regulation Of Phosphoprotein Phosphatase Activity
Tagcloud ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	amended atlantic bombing cerifera coast contaminant curled demolition explosive filtering germination hexahydro impacting juvenile metrics morella necrotic ppm seedling shoot shrub succession tnt triazine trinitro trinitrobenzene trinitrotoluene variably woody
Tagcloud (Difference) ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	amended atlantic bombing cerifera coast contaminant curled demolition explosive filtering germination hexahydro impacting juvenile metrics morella necrotic ppm seedling shoot shrub succession tnt triazine trinitro trinitrobenzene trinitrotoluene variably woody
Tagcloud (Intersection) ?