NHERF1 and P2RY1

Number of citations of the paper that reports this interaction (PubMedID 9671706)
25

Data Source:
HPRD (in vitro)

		NHERF1	P2RY1
Description		NHERF family PDZ scaffold protein 1	purinergic receptor P2Y1
Image
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Stereocilium Tip Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece Plasma Membrane Protein Complex	Plasma Membrane Cilium Cell Surface Postsynaptic Density Membrane Basolateral Plasma Membrane Apical Plasma Membrane Dendrite Cell Body Postsynaptic Membrane Presynaptic Active Zone Membrane Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Dopamine Receptor Binding Molecular Adaptor Activity Growth Factor Receptor Binding Channel Activator Activity	Nucleotide Binding G Protein-coupled ADP Receptor Activity G Protein-coupled Receptor Activity Protein Binding ATP Binding Signaling Receptor Regulator Activity A1 Adenosine Receptor Binding Signaling Receptor Activity ADP Binding G Protein-coupled Purinergic Nucleotide Receptor Activity G Protein-coupled ATP Receptor Activity Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	Morphogenesis Of An Epithelium Renal Sodium Ion Transport Sodium Ion Transport Plasma Membrane Organization Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Fibroblast Migration Negative Regulation Of Fibroblast Migration Negative Regulation Of Sodium Ion Transport Wnt Signaling Pathway Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Intracellular Phosphate Ion Homeostasis Bile Acid Secretion Glutathione Transport Cilium Organization Establishment Of Epithelial Cell Apical/basal Polarity Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Localization In Cell Establishment Of Golgi Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Gamma-aminobutyric Acid Import Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cerebrospinal Fluid Circulation Renal Phosphate Ion Absorption Import Across Plasma Membrane Transport Across Blood-brain Barrier Regulation Of Renal Phosphate Excretion Negative Regulation Of Cell Motility Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	G Protein-coupled Adenosine Receptor Signaling Pathway Monoatomic Ion Transport Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Hemostasis Glial Cell Migration Regulation Of Cell Shape Response To Mechanical Stimulus Negative Regulation Of Norepinephrine Secretion Signal Transduction Involved In Regulation Of Gene Expression Platelet Activation Positive Regulation Of Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Eating Behavior Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Secretion Establishment Of Localization In Cell Positive Regulation Of Penile Erection Positive Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Cellular Response To ATP Cellular Response To Purine-containing Compound Protein Localization To Plasma Membrane Relaxation Of Muscle Blood Vessel Diameter Maintenance Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis
Pathways			G alpha (q) signalling events P2Y receptors ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1
Drugs			Promethazine
Diseases		Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS			Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) Chronotype ( 30696823) Immune reponse to smallpox (secreted IL-2) ( 22610502) Metabolite levels ( 23823483) Serum sulfate level ( 27412988)
Interacting Genes		67 interacting genes: ABCC2 ABCC4 ACE2 ADRB2 AKAP10 AKT1 APPBP2 ATP6V1B1 ATP6V1E1 BCL10 BCL2A1 BRSK2 CDK1 CEBPA CFTR CLCN3 CNGA2 CRABP1 CTNNB1 DLGAP4 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OGT OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PHLPP1 PIN1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC13A1 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 UBE3A YAP1 YES1 ZNF468	3 interacting genes: ADORA1 NHERF1 NHERF2
Entrez ID		9368	5028
HPRD ID		05406	03103
Ensembl ID		ENSG00000109062	ENSG00000169860
Uniprot IDs		O14745	P47900
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H 6RQR	4XNV 4XNW 7XXH 8WJX
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane Plasma Membrane Monoatomic Ion Transport Transmembrane Transport Basolateral Plasma Membrane Regulation Of Biological Quality Membrane Sodium Ion Transport Organic Anion Transport Monoatomic Ion Transmembrane Transport PDZ Domain Binding System Process Monoatomic Cation Transport Metal Ion Transport Cellular Response To Oxygen-containing Compound Inorganic Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Homeostasis Regulation Of MAPK Cascade Homeostatic Process Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of Transport Response To Lipid Inorganic Cation Transmembrane Transport Regulation Of Protein Localization Intracellular Chemical Homeostasis Monoatomic Cation Transmembrane Transport Regulation Of PH Organic Anion Transmembrane Transporter Activity Microvillus Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Early Endosome Sodium-independent Organic Anion Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Monocarboxylic Acid Transport Chemical Homeostasis Enzyme Binding Regulation Of Signaling Regulation Of Cell Communication Intracellular Monoatomic Cation Homeostasis Solute:inorganic Anion Antiporter Activity Positive Regulation Of Protein Localization To Endosome Inorganic Anion Transport Monoatomic Anion Transport Intracellular Monoatomic Ion Homeostasis	Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Endomembrane System Protein-membrane Adaptor Activity Phosphatase Binding Localization Within Membrane Positive Regulation Of Nucleoside Transport Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Beta-catenin Binding Renal Phosphate Ion Absorption Renal System Process Negative Regulation Of Mucus Secretion Purine Nucleoside Binding Negative Regulation Of Neurotrophin Production Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Amino Acid Transport G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Respiratory System Process Regulation Of Mucus Secretion Heterotrimeric G-protein Binding Regulation Of Long-term Synaptic Depression Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cellular Localization Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Acute Inflammatory Response Vascular Process In Circulatory System Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Cell Motility Negative Regulation Of Locomotion G Protein-coupled Adenosine Receptor Activity Negative Regulation Of Cell Migration Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Asymmetric Synapse Negative Regulation Of Long-term Synaptic Depression Regulation Of Glomerular Filtration Mucus Secretion Axolemma Regulation Of Metal Ion Transport Circulatory System Process Inorganic Ion Homeostasis Positive Regulation Of Dephosphorylation Negative Regulation Of Glutamate Secretion Regulation Of Monoatomic Ion Transport Negative Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Circadian Rhythm G Protein-coupled Adenosine Receptor Signaling Pathway
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