SLC9A3R1 and NF2

Number of citations of the paper that reports this interaction (PMID 9430655)
44

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro, two hybrid)

		SLC9A3R1	NF2
Gene Name		solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	neurofibromin 2 (merlin)
Image
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Centrosome Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome Cell Periphery Sperm Midpiece	Nucleus Nucleolus Cytoplasm Early Endosome Cytoskeleton Plasma Membrane Adherens Junction Membrane Extrinsic Component Of Membrane Lamellipodium Cortical Actin Cytoskeleton Filopodium Membrane Cleavage Furrow Ruffle Membrane Apical Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Self-association Dopamine Receptor Binding Growth Factor Receptor Binding	Actin Binding Protein Binding
	Biological Process	Renal Sodium Ion Transport Protein Complex Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Cellular Protein Localization Glutathione Transport Regulation Of Excretion Regulation Of Protein Kinase Activity Negative Regulation Of Protein Kinase B Signaling Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Mesoderm Formation Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Ectoderm Development Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Schwann Cell Proliferation Hippocampus Development Negative Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Regulation Of Protein Stability Regulation Of Hippo Signaling Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of MAPK Cascade Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Negative Regulation Of JAK-STAT Cascade Positive Regulation Of Stress Fiber Assembly Lens Fiber Cell Differentiation Regulation Of Protein Localization To Nucleus Regulation Of Neural Precursor Cell Proliferation
Pathways
Drugs
Diseases
GWAS		Fibrinogen ( 20031577)	Carotid atherosclerosis in HIV infection ( 20009918)
Protein-Protein Interactions		52 interactors: ABCC2 ABCC4 ADRB2 AKAP10 ATP6V1B1 ATP6V1E1 BCL10 CFTR CLCN3 CNGA2 CTNNB1 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PIK3CA PLCB1 PLCB2 PTEN PTH1R RDX RLBP1 SCN4A SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468	24 interactors: AGAP2 AKT1 CCNB1IP1 CD44 CTNNB1 ERBB2 EZR HGS ITGB1 KDM1A MED28 PAK1 PXN PYGO2 RALGDS SCHIP1 SDCBP SGSM3 SLC9A3R1 SPTBN1 TARBP2 TSC1 VPRBP XPO1
Entrez ID		9368	4771
HPRD ID		05406	06980
Ensembl ID		ENSG00000109062	ENSG00000186575
Uniprot IDs		O14745	P35240
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF	1H4R 3U8Z
Enriched GO Terms of Interacting Partners?		Ion Homeostasis Ion Transmembrane Transport Transmembrane Transport Homeostatic Process Ion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Chemical Homeostasis Cellular Ion Homeostasis Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of PH Response To Organonitrogen Compound Cellular Chemical Homeostasis Monocarboxylic Acid Transport Positive Regulation Of Phospholipase Activity Transport Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Vasodilation Regulation Of Phosphorus Metabolic Process Cellular Response To Organonitrogen Compound Response To Stimulus Inorganic Anion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Cell Development Response To External Stimulus Monovalent Inorganic Cation Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Metal Ion Transport Cellular Homeostasis Establishment Of Endothelial Barrier Regulation Of Ion Transmembrane Transport Blood Coagulation Response To Estrogen Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Hemostasis Regulation Of Body Fluid Levels Signaling Wound Healing Response To Organic Substance Response To Hormone Cell Surface Receptor Signaling Pathway Cell Communication Cation Transport Positive Regulation Of Inositol Phosphate Biosynthetic Process	Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cell Development Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Cell Projection Organization Regulation Of Cellular Component Organization Enzyme Linked Receptor Protein Signaling Pathway Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Response To Growth Factor Axon Guidance Negative Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Anatomical Structure Development Positive Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Protein Localization Regulation Of Protein Kinase Activity Cell Morphogenesis Cell-matrix Adhesion Signal Transduction Nervous System Development Axonogenesis Cellular Response To Organic Substance Regulation Of Kinase Activity Movement Of Cell Or Subcellular Component Protein Localization Regulation Of Catalytic Activity Multicellular Organismal Development Developmental Process Cellular Localization Anatomical Structure Morphogenesis Axon Development Response To Stimulus Cellular Response To Growth Factor Stimulus
Tagcloud ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	22q allele alleles analysed assumed candidates carcinomas colorectal coupled cys digestive e1a gastric gene heterozygosity inactivation located missense mutation neurofibromatosis p300 participates rich sequencing somatic sscp suppressor though thought
Tagcloud (Difference) ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	22q allele alleles analysed assumed candidates carcinomas colorectal coupled cys digestive e1a gastric gene heterozygosity inactivation located missense mutation neurofibromatosis p300 participates rich sequencing somatic sscp suppressor though thought
Tagcloud (Intersection) ?