NHERF1 and LHCGR

Number of citations of the paper that reports this interaction (PubMedID 14507927)
0

Data Source:
HPRD (in vitro)

		NHERF1	LHCGR
Description		NHERF family PDZ scaffold protein 1	luteinizing hormone/choriogonadotropin receptor
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Stereocilium Tip Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece Plasma Membrane Protein Complex	Endosome Plasma Membrane Membrane Centriolar Satellite
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Dopamine Receptor Binding Molecular Adaptor Activity Growth Factor Receptor Binding Channel Activator Activity	G Protein-coupled Receptor Activity Luteinizing Hormone Receptor Activity G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Choriogonadotropin Hormone Receptor Activity Choriogonadotropin Hormone Binding
	Biological Process	Morphogenesis Of An Epithelium Renal Sodium Ion Transport Sodium Ion Transport Plasma Membrane Organization Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Fibroblast Migration Negative Regulation Of Fibroblast Migration Negative Regulation Of Sodium Ion Transport Wnt Signaling Pathway Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Intracellular Phosphate Ion Homeostasis Bile Acid Secretion Glutathione Transport Cilium Organization Establishment Of Epithelial Cell Apical/basal Polarity Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Localization In Cell Establishment Of Golgi Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Gamma-aminobutyric Acid Import Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cerebrospinal Fluid Circulation Renal Phosphate Ion Absorption Import Across Plasma Membrane Transport Across Blood-brain Barrier Regulation Of Renal Phosphate Excretion Negative Regulation Of Cell Motility Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Ovarian Follicle Development Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Ovulation Cycle Process Male Genitalia Development Cellular Response To Hormone Stimulus Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Response To Gonadotropin Luteinizing Hormone Signaling Pathway Development Of Secondary Male Sexual Characteristics Cognition Uterus Development Cellular Response To Gonadotropin Stimulus Cellular Response To Luteinizing Hormone Stimulus Seminiferous Tubule Development Regulation Of Steroid Hormone Biosynthetic Process
Pathways			Hormone ligand-binding receptors G alpha (s) signalling events
Drugs			Goserelin Menotropins Lutropin alfa Cetrorelix Choriogonadotropin alfa Buserelin Chorionic Gonadotropin (Human)
Diseases		Nephrolithiasis/osteoporosis, hypophosphatemic	Premature ovarian failure Precocious puberty, including: Central precocious puberty (CEPREPU); Familial male precocious puberty (FMPP) 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS			A body shape index ( 34021172) Body mass index ( 28892062) Hip circumference adjusted for BMI ( 34021172) Laterality in neovascular age-related macular degeneration ( 28775256) Polycystic ovary syndrome ( 21151128 22885925) Sex hormone-binding globulin levels ( 22829776) Triglyceride levels ( 32154731) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		67 interacting genes: ABCC2 ABCC4 ACE2 ADRB2 AKAP10 AKT1 APPBP2 ATP6V1B1 ATP6V1E1 BCL10 BCL2A1 BRSK2 CDK1 CEBPA CFTR CLCN3 CNGA2 CRABP1 CTNNB1 DLGAP4 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OGT OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PHLPP1 PIN1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC13A1 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 UBE3A YAP1 YES1 ZNF468	11 interacting genes: ARRB2 CANX CGA CGB3 CHST9 GIPC1 GNAI2 GNAS LHB NHERF1 TSHR
Entrez ID		9368	3973
HPRD ID		05406	01073
Ensembl ID		ENSG00000109062	ENSG00000138039
Uniprot IDs		O14745	P22888
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H 6RQR	7FIG 7FIH 7FII 7FIJ
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane Plasma Membrane Monoatomic Ion Transport Transmembrane Transport Basolateral Plasma Membrane Regulation Of Biological Quality Membrane Sodium Ion Transport Organic Anion Transport Monoatomic Ion Transmembrane Transport PDZ Domain Binding System Process Monoatomic Cation Transport Metal Ion Transport Cellular Response To Oxygen-containing Compound Inorganic Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Homeostasis Regulation Of MAPK Cascade Homeostatic Process Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of Transport Response To Lipid Inorganic Cation Transmembrane Transport Regulation Of Protein Localization Intracellular Chemical Homeostasis Monoatomic Cation Transmembrane Transport Regulation Of PH Organic Anion Transmembrane Transporter Activity Microvillus Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Early Endosome Sodium-independent Organic Anion Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Monocarboxylic Acid Transport Chemical Homeostasis Enzyme Binding Regulation Of Signaling Regulation Of Cell Communication Intracellular Monoatomic Cation Homeostasis Solute:inorganic Anion Antiporter Activity Positive Regulation Of Protein Localization To Endosome Inorganic Anion Transport Monoatomic Anion Transport Intracellular Monoatomic Ion Homeostasis	Pituitary Gonadotropin Complex G Protein-coupled Receptor Signaling Pathway Hormone-mediated Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signaling Receptor Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Signaling Regulation Of Biological Quality Cell Communication Hormone Activity Guanyl Nucleotide Binding Renal System Process Secretion By Cell G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Dopamine Receptor Signaling Pathway Signal Transduction Heterotrimeric G-protein Complex Hormone Metabolic Process Regulation Of Hormone Levels Hormone Biosynthetic Process Postsynaptic Signal Transduction Acidic Amino Acid Transport Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To Thyrotropin-releasing Hormone Renal Phosphate Ion Absorption Regulation Of ERK1 And ERK2 Cascade Angiotensin Receptor Binding G Protein-coupled Receptor Binding Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Follicle-stimulating Hormone Secretion Follicle-stimulating Hormone Activity Cellular Response To Hormone Stimulus Follicle-stimulating Hormone Complex Mu-type Opioid Receptor Binding Thyroid-stimulating Hormone Receptor Activity Thyroid-stimulating Hormone Signaling Pathway Response To Thyrotropin-releasing Hormone Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Negative Regulation Of Developmental Growth Positive Regulation Of Synaptic Transmission, Dopaminergic Golgi Lumen Follicle-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
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