NHERF1 and SLC4A7

Number of citations of the paper that reports this interaction (PubMedID 12403779)
0

Data Source:
BioGRID (pull down)

		NHERF1	SLC4A7
Description		NHERF family PDZ scaffold protein 1	solute carrier family 4 member 7
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Stereocilium Tip Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece Plasma Membrane Protein Complex	Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Stereocilium Cell Projection
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Dopamine Receptor Binding Molecular Adaptor Activity Growth Factor Receptor Binding Channel Activator Activity	Solute:inorganic Anion Antiporter Activity Protein Binding Monoatomic Anion Transmembrane Transporter Activity Sodium:bicarbonate Symporter Activity Symporter Activity
	Biological Process	Morphogenesis Of An Epithelium Renal Sodium Ion Transport Sodium Ion Transport Plasma Membrane Organization Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Fibroblast Migration Negative Regulation Of Fibroblast Migration Negative Regulation Of Sodium Ion Transport Wnt Signaling Pathway Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Intracellular Phosphate Ion Homeostasis Bile Acid Secretion Glutathione Transport Cilium Organization Establishment Of Epithelial Cell Apical/basal Polarity Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Localization In Cell Establishment Of Golgi Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Gamma-aminobutyric Acid Import Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cerebrospinal Fluid Circulation Renal Phosphate Ion Absorption Import Across Plasma Membrane Transport Across Blood-brain Barrier Regulation Of Renal Phosphate Excretion Negative Regulation Of Cell Motility Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Purine Nucleotide Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Monoatomic Ion Transport Sodium Ion Transport Monoatomic Anion Transport Inorganic Anion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Regulation Of Intracellular PH Transmembrane Transport Auditory Receptor Cell Development Cellular Response To Growth Factor Stimulus Phagosome Acidification Monoatomic Anion Transmembrane Transport
Pathways			Bicarbonate transporters RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle RHOF GTPase cycle
Drugs
Diseases		Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS			Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Blood pressure ( 21909110) Breast cancer ( 20453838 21263130 23535729 29059683 19330027) Breast cancer (early onset) ( 24493630) Diastolic blood pressure ( 28739976 27841878 27618452 27618447 25249183 21909115) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hypertension ( 25249183) Lymphocyte count ( 32888494) Macular telangiectasia type 2 ( 33654266) Macular thickness ( 30535121) Mean arterial pressure ( 27618448 29403010) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 29403010 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 21909115 30578418 28739976 25249183 29403010 27618452 28135244) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Urinary potassium excretion ( 31409800) Urinary potassium to creatinine ratio ( 30910378) Uterine fibroids ( 30194396)
Interacting Genes		67 interacting genes: ABCC2 ABCC4 ACE2 ADRB2 AKAP10 AKT1 APPBP2 ATP6V1B1 ATP6V1E1 BCL10 BCL2A1 BRSK2 CDK1 CEBPA CFTR CLCN3 CNGA2 CRABP1 CTNNB1 DLGAP4 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OGT OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PHLPP1 PIN1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC13A1 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 UBE3A YAP1 YES1 ZNF468	8 interacting genes: CFTR CIAO1 DLG4 KRTAP4-5 MTNR1B NHERF1 SLC4A4 YWHAB
Entrez ID		9368	9497
HPRD ID		05406	04521
Ensembl ID		ENSG00000109062	ENSG00000033867
Uniprot IDs		O14745	B5M450 E9PFN4 Q9Y6M7
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H 6RQR
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane Plasma Membrane Monoatomic Ion Transport Transmembrane Transport Basolateral Plasma Membrane Regulation Of Biological Quality Membrane Sodium Ion Transport Organic Anion Transport Monoatomic Ion Transmembrane Transport PDZ Domain Binding System Process Monoatomic Cation Transport Metal Ion Transport Cellular Response To Oxygen-containing Compound Inorganic Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Homeostasis Regulation Of MAPK Cascade Homeostatic Process Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of Transport Response To Lipid Inorganic Cation Transmembrane Transport Regulation Of Protein Localization Intracellular Chemical Homeostasis Monoatomic Cation Transmembrane Transport Regulation Of PH Organic Anion Transmembrane Transporter Activity Microvillus Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Early Endosome Sodium-independent Organic Anion Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Monocarboxylic Acid Transport Chemical Homeostasis Enzyme Binding Regulation Of Signaling Regulation Of Cell Communication Intracellular Monoatomic Cation Homeostasis Solute:inorganic Anion Antiporter Activity Positive Regulation Of Protein Localization To Endosome Inorganic Anion Transport Monoatomic Anion Transport Intracellular Monoatomic Ion Homeostasis	Chloride Channel Regulator Activity PDZ Domain Binding Regulation Of Membrane Potential Negative Regulation Of Transport Bicarbonate Transport Regulation Of Transport Organic Anion Transport Chemical Homeostasis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding P2Y1 Nucleotide Receptor Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Vascular Process In Circulatory System Circulatory System Process Renal Phosphate Ion Absorption Regulation Of Cellular PH Positive Regulation Of Anion Channel Activity Regulation Of PH Regulation Of Protein Transport Regulation Of Intracellular PH Cell Periphery Regulation Of Behavior Transport Across Blood-brain Barrier Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Intracellular Chemical Homeostasis Regulation Of Establishment Of Protein Localization Positive Regulation Of Monoatomic Anion Transport Beta-1 Adrenergic Receptor Binding Regulation Of Nervous System Process Regulation Of Grooming Behavior Negative Regulation Of Protein Transport Type 3 Metabotropic Glutamate Receptor Binding Inorganic Anion Transport Monoatomic Anion Transmembrane Transport Positive Regulation Of Enamel Mineralization Homeostatic Process Monoatomic Anion Transport Regulation Of System Process Melatonin Receptor Activity Negative Regulation Of Establishment Of Protein Localization Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Sodium:bicarbonate Symporter Activity Cellular Homeostasis Regulation Of Insulin Secretion Positive Regulation Of Tooth Mineralization Transepithelial Water Transport
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