NHERF1 and KCNJ1

Number of citations of the paper that reports this interaction (PubMedID 14604981)
0

Data Source:
BioGRID (pull down, two hybrid)
HPRD (in vitro, in vivo, two hybrid)

		NHERF1	KCNJ1
Description		NHERF family PDZ scaffold protein 1	potassium inwardly rectifying channel subfamily J member 1
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Stereocilium Tip Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece Plasma Membrane Protein Complex	Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Dopamine Receptor Binding Molecular Adaptor Activity Growth Factor Receptor Binding Channel Activator Activity	Nucleotide Binding Inward Rectifier Potassium Channel Activity Potassium Channel Activity ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP-activated Inward Rectifier Potassium Channel Activity
	Biological Process	Morphogenesis Of An Epithelium Renal Sodium Ion Transport Sodium Ion Transport Plasma Membrane Organization Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Fibroblast Migration Negative Regulation Of Fibroblast Migration Negative Regulation Of Sodium Ion Transport Wnt Signaling Pathway Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Intracellular Phosphate Ion Homeostasis Bile Acid Secretion Glutathione Transport Cilium Organization Establishment Of Epithelial Cell Apical/basal Polarity Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Localization In Cell Establishment Of Golgi Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Gamma-aminobutyric Acid Import Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cerebrospinal Fluid Circulation Renal Phosphate Ion Absorption Import Across Plasma Membrane Transport Across Blood-brain Barrier Regulation Of Renal Phosphate Excretion Negative Regulation Of Cell Motility Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Kidney Development Tissue Homeostasis Monoatomic Ion Transport Potassium Ion Transport Post-embryonic Development Gene Expression Metal Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Renal Sodium Ion Absorption Circulatory System Development Potassium Ion Import Across Plasma Membrane
Pathways			Potassium transport channels
Drugs			Bethanidine Glimepiride Minoxidil Acetohexamide Ritodrine Tolbutamide Glymidine Yohimbine Agmatine Butamben
Diseases		Nephrolithiasis/osteoporosis, hypophosphatemic	Bartter syndrome
GWAS
Interacting Genes		67 interacting genes: ABCC2 ABCC4 ACE2 ADRB2 AKAP10 AKT1 APPBP2 ATP6V1B1 ATP6V1E1 BCL10 BCL2A1 BRSK2 CDK1 CEBPA CFTR CLCN3 CNGA2 CRABP1 CTNNB1 DLGAP4 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OGT OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PHLPP1 PIN1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC13A1 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 UBE3A YAP1 YES1 ZNF468	6 interacting genes: GOLGA3 NHERF1 NHERF2 PRKCD SGK1 SH3RF1
Entrez ID		9368	3758
HPRD ID		05406	08981
Ensembl ID		ENSG00000109062	ENSG00000151704
Uniprot IDs		O14745	A8K432 P48048
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H 6RQR
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane Plasma Membrane Monoatomic Ion Transport Transmembrane Transport Basolateral Plasma Membrane Regulation Of Biological Quality Membrane Sodium Ion Transport Organic Anion Transport Monoatomic Ion Transmembrane Transport PDZ Domain Binding System Process Monoatomic Cation Transport Metal Ion Transport Cellular Response To Oxygen-containing Compound Inorganic Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Homeostasis Regulation Of MAPK Cascade Homeostatic Process Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of Transport Response To Lipid Inorganic Cation Transmembrane Transport Regulation Of Protein Localization Intracellular Chemical Homeostasis Monoatomic Cation Transmembrane Transport Regulation Of PH Organic Anion Transmembrane Transporter Activity Microvillus Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Early Endosome Sodium-independent Organic Anion Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Monocarboxylic Acid Transport Chemical Homeostasis Enzyme Binding Regulation Of Signaling Regulation Of Cell Communication Intracellular Monoatomic Cation Homeostasis Solute:inorganic Anion Antiporter Activity Positive Regulation Of Protein Localization To Endosome Inorganic Anion Transport Monoatomic Anion Transport Intracellular Monoatomic Ion Homeostasis	Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Chloride Channel Regulator Activity Regulation Of Apoptotic Signaling Pathway Response To Aldosterone Positive Regulation Of Apoptotic Signaling Pathway Renal Sodium Ion Transport Protein-membrane Adaptor Activity Response To Mineralocorticoid Positive Regulation Of Transporter Activity Renal Absorption Endomembrane System Phosphatase Binding Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Regulation Of Protein Import Into Nucleus Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Cellular Response To UV Positive Regulation Of Sphingomyelin Catabolic Process Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Cellular Response To Light Stimulus Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity Termination Of Signal Transduction Beta-catenin Binding Negative Regulation Of Filopodium Assembly Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Deoxyribonuclease Activity Protein Kinase C Signaling Renal System Process Extracellular Exosome Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Negative Regulation Of MAPK Cascade Positive Regulation Of Programmed Cell Death Response To UV Regulation Of Intracellular Protein Transport Positive Regulation Of Ceramide Biosynthetic Process Regulation Of Protein Localization To Nucleus Regulation Of Endodeoxyribonuclease Activity Regulation Of Intracellular Signal Transduction Regulation Of Phospholipid Catabolic Process Cellular Response To Aldosterone
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