SLC9A3R1 and CLCN3

Number of citations of the paper that reports this interaction (PMID 12471024)
25

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		SLC9A3R1	CLCN3
Gene Name		solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	chloride channel, voltage-sensitive 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Centrosome Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome Cell Periphery Sperm Midpiece	Golgi Membrane Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Vesicle Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Secretory Granule Transport Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Specific Granule Phagocytic Vesicle
	Molecular Function	Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Self-association Dopamine Receptor Binding Growth Factor Receptor Binding	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Antiporter Activity PDZ Domain Binding Protein Homodimerization Activity Protein Heterodimerization Activity Volume-sensitive Chloride Channel Activity
	Biological Process	Renal Sodium Ion Transport Protein Complex Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Cellular Protein Localization Glutathione Transport Regulation Of Excretion Regulation Of Protein Kinase Activity Negative Regulation Of Protein Kinase B Signaling Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Transport Regulation Of PH Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Anion Transport Negative Regulation Of Cell Volume Endosomal Lumen Acidification Transmembrane Transport Chloride Transmembrane Transport
Pathways			Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS		Fibrinogen ( 20031577)
Protein-Protein Interactions		52 interactors: ABCC2 ABCC4 ADRB2 AKAP10 ATP6V1B1 ATP6V1E1 BCL10 CFTR CLCN3 CNGA2 CTNNB1 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PIK3CA PLCB1 PLCB2 PTEN PTH1R RDX RLBP1 SCN4A SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468	4 interactors: CFTR GOPC PDZK1 SLC9A3R1
Entrez ID		9368	1182
HPRD ID		05406	02785
Ensembl ID		ENSG00000109062	ENSG00000109572
Uniprot IDs		O14745	B3KXK0 B9EGJ9 P51790
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF
Enriched GO Terms of Interacting Partners?		Ion Homeostasis Ion Transmembrane Transport Transmembrane Transport Homeostatic Process Ion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Chemical Homeostasis Cellular Ion Homeostasis Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of PH Response To Organonitrogen Compound Cellular Chemical Homeostasis Monocarboxylic Acid Transport Positive Regulation Of Phospholipase Activity Transport Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Vasodilation Regulation Of Phosphorus Metabolic Process Cellular Response To Organonitrogen Compound Response To Stimulus Inorganic Anion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Cell Development Response To External Stimulus Monovalent Inorganic Cation Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Metal Ion Transport Cellular Homeostasis Establishment Of Endothelial Barrier Regulation Of Ion Transmembrane Transport Blood Coagulation Response To Estrogen Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Hemostasis Regulation Of Body Fluid Levels Signaling Wound Healing Response To Organic Substance Response To Hormone Cell Surface Receptor Signaling Pathway Cell Communication Cation Transport Positive Regulation Of Inositol Phosphate Biosynthetic Process	Regulation Of Ion Transmembrane Transport Organic Anion Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Anion Transport Cytoplasmic Sequestering Of CFTR Protein Renal Phosphate Ion Absorption Positive Regulation Of Voltage-gated Chloride Channel Activity Monocarboxylic Acid Transport Spermatid Development Regulation Of Anion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Spermatid Differentiation Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Positive Regulation Of Ion Transport Regulation Of Chloride Transport Germ Cell Development Inorganic Anion Transport Regulation Of Intracellular Protein Transport Cellular Protein Localization Renal Sodium Ion Transport Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Iodide Transport Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Lipid Transport Carboxylic Acid Transport Organic Acid Transport Negative Regulation Of Golgi To Plasma Membrane Protein Transport Negative Regulation Of Sodium Ion Transmembrane Transport Lipid Localization Transepithelial Chloride Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Golgi To Plasma Membrane Protein Transport Ion Transport Negative Regulation Of Transport Bile Acid Secretion Carnitine Transport Oligopeptide Transport Regulation Of Intracellular Transport Transport Protein Localization Negative Regulation Of Sodium Ion Transport Renal Absorption Regulation Of Proton Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cellular Ion Homeostasis Transepithelial Transport
Tagcloud ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	10mum 200mum 3mum bkca blockers cardiac channels clamp conductance currents dids diisothiocyanatostilbene disodium disulfonic fibroblasts g0 gated heterogeneously kca1 knock na patch paxilline remarkably sirnas tetrodotoxin vol voltage
Tagcloud (Difference) ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	10mum 200mum 3mum bkca blockers cardiac channels clamp conductance currents dids diisothiocyanatostilbene disodium disulfonic fibroblasts g0 gated heterogeneously kca1 knock na patch paxilline remarkably sirnas tetrodotoxin vol voltage
Tagcloud (Intersection) ?