SLC9A3R1 and SLC26A3

Number of citations of the paper that reports this interaction (PMID 12369822)
23

Data Source:
HPRD (in vitro)

		SLC9A3R1	SLC26A3
Gene Name		solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	solute carrier family 26 (anion exchanger), member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Centrosome Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome Cell Periphery Sperm Midpiece	Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Sperm Midpiece
	Molecular Function	Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Self-association Dopamine Receptor Binding Growth Factor Receptor Binding	Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Transporter Activity Protein Binding Secondary Active Sulfate Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Anion:anion Antiporter Activity
	Biological Process	Renal Sodium Ion Transport Protein Complex Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Cellular Protein Localization Glutathione Transport Regulation Of Excretion Regulation Of Protein Kinase Activity Negative Regulation Of Protein Kinase B Signaling Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Regulation Of Transcription, DNA-templated Ion Transport Anion Transport Excretion Bicarbonate Transport Sperm Capacitation Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Cellular Response To CAMP Sulfate Transmembrane Transport Chloride Transmembrane Transport Regulation Of Nucleic Acid-templated Transcription
Pathways			Transport of inorganic cations/anions and amino acids/oligopeptides Multifunctional anion exchangers SLC-mediated transmembrane transport
Drugs
Diseases
GWAS		Fibrinogen ( 20031577)	Ulcerative colitis ( 19915573 19122664)
Protein-Protein Interactions		52 interactors: ABCC2 ABCC4 ADRB2 AKAP10 ATP6V1B1 ATP6V1E1 BCL10 CFTR CLCN3 CNGA2 CTNNB1 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PIK3CA PLCB1 PLCB2 PTEN PTH1R RDX RLBP1 SCN4A SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468	2 interactors: SLC9A3R1 SLC9A3R2
Entrez ID		9368	1811
HPRD ID		05406	00544
Ensembl ID		ENSG00000109062	ENSG00000091138
Uniprot IDs		O14745	P40879
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF
Enriched GO Terms of Interacting Partners?		Ion Homeostasis Ion Transmembrane Transport Transmembrane Transport Homeostatic Process Ion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Chemical Homeostasis Cellular Ion Homeostasis Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of PH Response To Organonitrogen Compound Cellular Chemical Homeostasis Monocarboxylic Acid Transport Positive Regulation Of Phospholipase Activity Transport Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Vasodilation Regulation Of Phosphorus Metabolic Process Cellular Response To Organonitrogen Compound Response To Stimulus Inorganic Anion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Cell Development Response To External Stimulus Monovalent Inorganic Cation Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Metal Ion Transport Cellular Homeostasis Establishment Of Endothelial Barrier Regulation Of Ion Transmembrane Transport Blood Coagulation Response To Estrogen Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Hemostasis Regulation Of Body Fluid Levels Signaling Wound Healing Response To Organic Substance Response To Hormone Cell Surface Receptor Signaling Pathway Cell Communication Cation Transport Positive Regulation Of Inositol Phosphate Biosynthetic Process	Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Phosphatidylinositol 3-kinase Signaling Renal Phosphate Ion Absorption Glutathione Transport Negative Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Intracellular Signal Transduction Renal Sodium Ion Transport Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Bile Acid Secretion Oligopeptide Transport Negative Regulation Of Sodium Ion Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Renal Absorption Regulation Of Proton Transport Phosphate Ion Homeostasis Microvillus Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Complex Assembly Regulation Of Excretion Negative Regulation Of Signal Transduction Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Signaling Bile Acid And Bile Salt Transport Dopamine Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Transporter Activity Anion Homeostasis Negative Regulation Of Ion Transmembrane Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Transmembrane Transport Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Acid Secretion Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Sodium Ion Transport Regulation Of Intracellular Signal Transduction Cellular Component Assembly Peptide Transport Negative Regulation Of Ion Transport Renal System Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Kinase B Signaling Amide Transport
Tagcloud ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	anhydrase aqp3 aquaglyceroporin3 carbachol carbonic clostridium colonic colonizing compliant doubled electrolyte elicits faecalis fusobacterium germfree gf goblet innocuum intestinalis lactobacillus microbiotas monocolonized mucin mucus pioneer resides shortly simplified suckling
Tagcloud (Difference) ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	anhydrase aqp3 aquaglyceroporin3 carbachol carbonic clostridium colonic colonizing compliant doubled electrolyte elicits faecalis fusobacterium germfree gf goblet innocuum intestinalis lactobacillus microbiotas monocolonized mucin mucus pioneer resides shortly simplified suckling
Tagcloud (Intersection) ?