NHERF1 and SLC4A8

Number of citations of the paper that reports this interaction (PubMedID 12444018)
0

Data Source:
HPRD (in vitro)

		NHERF1	SLC4A8
Description		NHERF family PDZ scaffold protein 1	solute carrier family 4 member 8
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Stereocilium Tip Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece Plasma Membrane Protein Complex	Plasma Membrane Synaptic Vesicle Membrane Basolateral Plasma Membrane Apical Plasma Membrane Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Neuronal Cell Body Membrane Presynaptic Membrane Neuron Projection Terminal Bouton Axon Terminus Synapse Glial Cell Projection Hippocampal Mossy Fiber Presynapse Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Dopamine Receptor Binding Molecular Adaptor Activity Growth Factor Receptor Binding Channel Activator Activity	Solute:inorganic Anion Antiporter Activity Zinc Ion Binding Monoatomic Anion Transmembrane Transporter Activity Sodium:bicarbonate Symporter Activity Sodium Ion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Antiporter Activity Identical Protein Binding Sodium,bicarbonate:chloride Antiporter Activity
	Biological Process	Morphogenesis Of An Epithelium Renal Sodium Ion Transport Sodium Ion Transport Plasma Membrane Organization Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Fibroblast Migration Negative Regulation Of Fibroblast Migration Negative Regulation Of Sodium Ion Transport Wnt Signaling Pathway Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Intracellular Phosphate Ion Homeostasis Bile Acid Secretion Glutathione Transport Cilium Organization Establishment Of Epithelial Cell Apical/basal Polarity Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Localization In Cell Establishment Of Golgi Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Gamma-aminobutyric Acid Import Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cerebrospinal Fluid Circulation Renal Phosphate Ion Absorption Import Across Plasma Membrane Transport Across Blood-brain Barrier Regulation Of Renal Phosphate Excretion Negative Regulation Of Cell Motility Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Monoatomic Ion Transport Sodium Ion Transport Monoatomic Anion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Modulation Of Chemical Synaptic Transmission Regulation Of Intracellular PH Transmembrane Transport Basolateral Protein Secretion Transport Across Blood-brain Barrier Chloride Transmembrane Transport Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Synaptic Vesicle Exocytosis
Pathways			Bicarbonate transporters
Drugs
Diseases		Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) Fruit consumption ( 32066663) Problematic alcohol use ( 32451486) Response to antidepressants and depression ( 27622933) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		67 interacting genes: ABCC2 ABCC4 ACE2 ADRB2 AKAP10 AKT1 APPBP2 ATP6V1B1 ATP6V1E1 BCL10 BCL2A1 BRSK2 CDK1 CEBPA CFTR CLCN3 CNGA2 CRABP1 CTNNB1 DLGAP4 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OGT OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PHLPP1 PIN1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC13A1 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 UBE3A YAP1 YES1 ZNF468	3 interacting genes: CA2 CFTR NHERF1
Entrez ID		9368	9498
HPRD ID		05406	05430
Ensembl ID		ENSG00000109062	ENSG00000050438
Uniprot IDs		O14745	Q2Y0W8
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H 6RQR	5JHO
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane Plasma Membrane Monoatomic Ion Transport Transmembrane Transport Basolateral Plasma Membrane Regulation Of Biological Quality Membrane Sodium Ion Transport Organic Anion Transport Monoatomic Ion Transmembrane Transport PDZ Domain Binding System Process Monoatomic Cation Transport Metal Ion Transport Cellular Response To Oxygen-containing Compound Inorganic Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Homeostasis Regulation Of MAPK Cascade Homeostatic Process Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of Transport Response To Lipid Inorganic Cation Transmembrane Transport Regulation Of Protein Localization Intracellular Chemical Homeostasis Monoatomic Cation Transmembrane Transport Regulation Of PH Organic Anion Transmembrane Transporter Activity Microvillus Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Early Endosome Sodium-independent Organic Anion Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Monocarboxylic Acid Transport Chemical Homeostasis Enzyme Binding Regulation Of Signaling Regulation Of Cell Communication Intracellular Monoatomic Cation Homeostasis Solute:inorganic Anion Antiporter Activity Positive Regulation Of Protein Localization To Endosome Inorganic Anion Transport Monoatomic Anion Transport Intracellular Monoatomic Ion Homeostasis	Chloride Channel Regulator Activity Regulation Of Monoatomic Anion Transport Regulation Of Monoatomic Ion Transport Intracellular Chemical Homeostasis Cellular Homeostasis Apical Part Of Cell Regulation Of Cellular PH Regulation Of Intracellular PH PDZ Domain Binding Regulation Of PH Chemical Homeostasis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Renal Phosphate Ion Absorption Positive Regulation Of Dipeptide Transmembrane Transport Cyanamide Hydratase Activity Positive Regulation Of Anion Channel Activity Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Homeostatic Process Positive Regulation Of Monoatomic Anion Transport Type 3 Metabotropic Glutamate Receptor Binding Anatomical Structure Morphogenesis Positive Regulation Of Enamel Mineralization Arylesterase Activity Positive Regulation Of Cellular PH Reduction Regulation Of Transport Regulation Of Chloride Transport Transepithelial Water Transport Growth Factor Receptor Binding Positive Regulation Of Cell Communication Morphogenesis Of An Epithelium Positive Regulation Of Signaling Positive Regulation Of Tooth Mineralization Organic Anion Transport Chloride Channel Inhibitor Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Gamma-aminobutyric Acid Import Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Apical Plasma Membrane
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