RDX and NHERF1

Number of citations of the paper that reports this interaction (PubMedID 12499563)
0

Data Source:
HPRD (in vitro, in vivo)

		RDX	NHERF1
Description		radixin	NHERF family PDZ scaffold protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Microvillus Adherens Junction Focal Adhesion Membrane Apical Plasma Membrane Lamellipodium Filopodium T-tubule Midbody Cortical Actin Cytoskeleton Cleavage Furrow Stereocilium Cell Projection Apical Part Of Cell Cell Tip Extracellular Exosome Cell Periphery Stereocilium Base	Ruffle Nucleus Cytoplasm Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Stereocilium Tip Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece Plasma Membrane Protein Complex
	Molecular Function	RNA Binding Actin Binding Protein Binding Cytoskeletal Protein Binding Protein Domain Specific Binding Cadherin Binding Cell Adhesion Molecule Binding Protein Kinase A Binding ATPase Binding	Signaling Receptor Binding Protein Binding Beta-catenin Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Dopamine Receptor Binding Molecular Adaptor Activity Growth Factor Receptor Binding Channel Activator Activity
	Biological Process	Regulation Of Cell Shape Positive Regulation Of Gene Expression Protein Kinase A Signaling Microvillus Assembly Regulation Of Rap Protein Signal Transduction Cellular Response To Platelet-derived Growth Factor Stimulus Apical Protein Localization Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Barbed-end Actin Filament Capping Actin Filament Capping Establishment Of Endothelial Barrier Establishment Of Protein Localization To Plasma Membrane Protein Localization To Plasma Membrane Cellular Response To Thyroid Hormone Stimulus Regulation Of Postsynaptic Neurotransmitter Receptor Diffusion Trapping Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Regulation Of Adherens Junction Organization Positive Regulation Of Early Endosome To Late Endosome Transport	Morphogenesis Of An Epithelium Renal Sodium Ion Transport Sodium Ion Transport Plasma Membrane Organization Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Fibroblast Migration Negative Regulation Of Fibroblast Migration Negative Regulation Of Sodium Ion Transport Wnt Signaling Pathway Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Intracellular Phosphate Ion Homeostasis Bile Acid Secretion Glutathione Transport Cilium Organization Establishment Of Epithelial Cell Apical/basal Polarity Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Localization In Cell Establishment Of Golgi Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Gamma-aminobutyric Acid Import Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cerebrospinal Fluid Circulation Renal Phosphate Ion Absorption Import Across Plasma Membrane Transport Across Blood-brain Barrier Regulation Of Renal Phosphate Excretion Negative Regulation Of Cell Motility Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Recycling pathway of L1 Recycling pathway of L1 Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs		1D-myo-inositol 1,4,5-trisphosphate
Diseases			Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS		Cognitive function ( 24684796) Computer vision syndrome ( 33941792) Coronary artery disease ( 32469254) Multiple sclerosis ( 31604244)
Interacting Genes		23 interacting genes: ABCC2 ARHGDIA C1QTNF9 CALM1 CPNE1 CPNE2 CPNE4 DRD3 EZR FTCD GNA13 ICAM2 ITGB2 L1CAM LINC01554 NHERF1 NHERF2 PRPF38A PSME3 RBPMS ROCK1 TSC1 VPS11	67 interacting genes: ABCC2 ABCC4 ACE2 ADRB2 AKAP10 AKT1 APPBP2 ATP6V1B1 ATP6V1E1 BCL10 BCL2A1 BRSK2 CDK1 CEBPA CFTR CLCN3 CNGA2 CRABP1 CTNNB1 DLGAP4 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OGT OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PHLPP1 PIN1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC13A1 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 UBE3A YAP1 YES1 ZNF468
Entrez ID		5962	9368
HPRD ID		01534	05406
Ensembl ID		ENSG00000137710	ENSG00000109062
Uniprot IDs		B0YJ88 P35241 Q6PKD3	O14745
PDB IDs			1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H 6RQR
Enriched GO Terms of Interacting Partners?		Type 2 Metabotropic Glutamate Receptor Binding Membrane Docking Type 3 Metabotropic Glutamate Receptor Binding Membrane To Membrane Docking Response To Calcium Ion Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Cell Shape Leukocyte Cell-cell Adhesion Protein Localization To Membrane Microvillus Organization Positive Regulation Of Early Endosome To Late Endosome Transport Microvillus Assembly Calcium-dependent Phospholipid Binding Plasma Membrane Response To Metal Ion Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Rho Protein Signal Transduction Microvillus Receptor Internalization Uropod Protein Localization To Plasma Membrane Cellular Response To Calcium Ion Regulation Of Intracellular Signal Transduction Establishment Of Epithelial Cell Apical/basal Polarity Protein Localization To Cell Periphery Regulation Of Early Endosome To Late Endosome Transport Focal Adhesion Extracellular Exosome Associative Learning Cell Periphery Regulation Of Cell Morphogenesis G Protein-coupled Dopamine Receptor Signaling Pathway Cell-matrix Adhesion Ruffle Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Negative Regulation Of Intracellular Signal Transduction Cell-cell Adhesion Acid Secretion Microvillus Membrane Gland Morphogenesis Establishment Of Epithelial Cell Polarity Localization Within Membrane Positive Regulation Of Focal Adhesion Assembly Cortical Actin Cytoskeleton Organization Monocarboxylic Acid Transport Regulation Of Vesicle-mediated Transport Protein-membrane Adaptor Activity	Apical Plasma Membrane Plasma Membrane Monoatomic Ion Transport Transmembrane Transport Basolateral Plasma Membrane Regulation Of Biological Quality Membrane Sodium Ion Transport Organic Anion Transport Monoatomic Ion Transmembrane Transport PDZ Domain Binding System Process Monoatomic Cation Transport Metal Ion Transport Cellular Response To Oxygen-containing Compound Inorganic Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Homeostasis Regulation Of MAPK Cascade Homeostatic Process Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of Transport Response To Lipid Inorganic Cation Transmembrane Transport Regulation Of Protein Localization Intracellular Chemical Homeostasis Monoatomic Cation Transmembrane Transport Regulation Of PH Organic Anion Transmembrane Transporter Activity Microvillus Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Early Endosome Sodium-independent Organic Anion Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Monocarboxylic Acid Transport Chemical Homeostasis Enzyme Binding Regulation Of Signaling Regulation Of Cell Communication Intracellular Monoatomic Cation Homeostasis Solute:inorganic Anion Antiporter Activity Positive Regulation Of Protein Localization To Endosome Inorganic Anion Transport Monoatomic Anion Transport Intracellular Monoatomic Ion Homeostasis
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