RDX and ROCK1

Number of citations of the paper that reports this interaction (PMID 9456324)
188

Data Source:
HPRD (in vitro)

		RDX	ROCK1
Gene Name		radixin	Rho-associated, coiled-coil containing protein kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Extrinsic Component Of Membrane Lamellipodium Filopodium T-tubule Cleavage Furrow Stereocilium Apical Part Of Cell Cell Tip Extracellular Vesicular Exosome Cell Periphery	Golgi Membrane Ruffle Centriole Cytosol Cytoskeleton Plasma Membrane Lamellipodium Bleb
	Molecular Function	Actin Binding Protein Binding Poly(A) RNA Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP-Rho Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Gene Expression Microvillus Assembly Apical Protein Localization Actin Filament Capping Establishment Of Endothelial Barrier	Apical Constriction Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Smooth Muscle Contraction Leukocyte Cell-cell Adhesion Signal Transduction Rho Protein Signal Transduction Axon Guidance Negative Regulation Of Angiogenesis Membrane To Membrane Docking Actin Cytoskeleton Organization Regulation Of Cell Adhesion Bleb Assembly Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Neuron Apoptotic Process Regulation Of Keratinocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Leukocyte Migration Leukocyte Tethering Or Rolling Myoblast Migration Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Assembly Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility
Pathways		Axon guidance L1CAM interactions Recycling pathway of L1	Signaling by GPCR Apoptotic cleavage of cellular proteins Axon guidance Semaphorin interactions Apoptotic execution phase VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse GPCR downstream signaling Signaling by VEGF Programmed Cell Death EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs			HYDROXYFASUDIL (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ABCC2 ARHGDIA CALM1 CPNE1 CPNE2 CPNE4 DRD3 EZR GNA13 ICAM2 ITGB2 L1CAM ROCK1 SLC9A3R1 SLC9A3R2 TSC1	32 interactors: ADD1 ARHGAP24 C6orf165 CASP3 CASP7 CDC25A CDC34 CRMP1 DES DPYSL2 EZR FAM124A GFAP IKBKB IRS1 ITSN2 LIMK1 LIMK2 LMO2 MAGEB4 MSN PFN2 POLR3C PPP1R12A PTK2 RDX RHOA RHOC RND3 SMAD2 TSG101 VIM
Entrez ID		5962	6093
HPRD ID		01534	03414
Ensembl ID		ENSG00000137710
Uniprot IDs		B0YJ88 P35241 Q6PKD3	Q13464
PDB IDs			1S1C 2ESM 2ETK 2ETR 2V55 3D9V 3NCZ 3NDM 3O0Z 3TV7 3TWJ 3V8S
Enriched GO Terms of Interacting Partners?		Membrane To Membrane Docking Cellular Extravasation Negative Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Transporter Activity Negative Regulation Of Ion Transmembrane Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Transmembrane Transport Rho Protein Signal Transduction Negative Regulation Of Sodium Ion Transmembrane Transport Single Organismal Cell-cell Adhesion Cellular Chemical Homeostasis Cell Surface Receptor Signaling Pathway Membrane Docking Negative Regulation Of Ion Transport Negative Regulation Of Sodium Ion Transport Regulation Of Proton Transport Leukocyte Cell-cell Adhesion Leukocyte Tethering Or Rolling Regulation Of Locomotion Cell Adhesion Cellular Homeostasis Microvillus Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Microvillus Organization Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Cellular Component Organization Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Monocarboxylic Acid Transport Regulation Of Ion Transmembrane Transporter Activity Response To Organonitrogen Compound Regulation Of Transmembrane Transporter Activity Negative Regulation Of Intracellular Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Regulation Of Excretion Chemical Homeostasis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Regulation Of Cell Shape Cell-matrix Adhesion Cellular Ion Homeostasis Movement Of Cell Or Subcellular Component Regulation Of Cell Morphogenesis Regulation Of Sodium Ion Transmembrane Transporter Activity Nervous System Development Response To Amphetamine Regulation Of Phosphoprotein Phosphatase Activity	Regulation Of Cellular Component Organization Cytoskeleton Organization Negative Regulation Of Cell Projection Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Cell Development Regulation Of Cell Projection Organization Cell Differentiation Positive Regulation Of Metabolic Process Epithelium Development Axon Guidance Movement Of Cell Or Subcellular Component Actin Filament-based Process Organelle Organization Regulation Of Cellular Process Anatomical Structure Development Cell Morphogenesis Involved In Differentiation Skeletal Muscle Satellite Cell Migration Axonogenesis Cell Morphogenesis Neuron Projection Development Axon Development Neuron Differentiation System Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neuron Projection Development Cell Projection Organization Response To Stimulus Response To Growth Factor Establishment Of Endothelial Barrier Chemotaxis Regulation Of Metabolic Process Developmental Process Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Neuron Projection Morphogenesis Negative Regulation Of Neuron Projection Development Locomotion Neuron Development Wound Healing, Spreading Of Cells Neurogenesis Negative Regulation Of Ruffle Assembly Membrane To Membrane Docking Tissue Development Bergmann Glial Cell Differentiation Positive Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Multicellular Organismal Development Endothelial Cell Development Positive Regulation Of Actin Filament Bundle Assembly
Tagcloud ?		amended atlantic bombing cerifera coast contaminant curled demolition explosive filtering germination hexahydro impacting juvenile metrics morella necrotic ppm seedling shoot shrub succession tnt triazine trinitro trinitrobenzene trinitrotoluene variably woody	angiogenic au contributor decay disperse dispersion ecs eliciting gtpase herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory
Tagcloud (Difference) ?		amended atlantic bombing cerifera coast contaminant curled demolition explosive filtering germination hexahydro impacting juvenile metrics morella necrotic ppm seedling shoot shrub succession tnt triazine trinitro trinitrobenzene trinitrotoluene variably woody	angiogenic au contributor decay disperse dispersion ecs eliciting gtpase herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory
Tagcloud (Intersection) ?