RDX and DRD3

Number of citations of the paper that reports this interaction (PubMedID 14499480)
0

Data Source:
BioGRID (two hybrid)

		RDX	DRD3
Description		radixin	dopamine receptor D3
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Microvillus Adherens Junction Focal Adhesion Membrane Apical Plasma Membrane Lamellipodium Filopodium T-tubule Midbody Cortical Actin Cytoskeleton Cleavage Furrow Stereocilium Cell Projection Apical Part Of Cell Cell Tip Extracellular Exosome Cell Periphery Stereocilium Base	Plasma Membrane Membrane Synapse
	Molecular Function	RNA Binding Actin Binding Protein Binding Cytoskeletal Protein Binding Protein Domain Specific Binding Cadherin Binding Cell Adhesion Molecule Binding Protein Kinase A Binding ATPase Binding	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding
	Biological Process	Regulation Of Cell Shape Positive Regulation Of Gene Expression Protein Kinase A Signaling Microvillus Assembly Regulation Of Rap Protein Signal Transduction Cellular Response To Platelet-derived Growth Factor Stimulus Apical Protein Localization Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Barbed-end Actin Filament Capping Actin Filament Capping Establishment Of Endothelial Barrier Establishment Of Protein Localization To Plasma Membrane Protein Localization To Plasma Membrane Cellular Response To Thyroid Hormone Stimulus Regulation Of Postsynaptic Neurotransmitter Receptor Diffusion Trapping Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Regulation Of Adherens Junction Organization Positive Regulation Of Early Endosome To Late Endosome Transport	Synaptic Transmission, Dopaminergic G Protein-coupled Receptor Internalization Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Learning Or Memory Learning Locomotory Behavior Visual Learning Response To Xenobiotic Stimulus Regulation Of Dopamine Secretion Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Response To Histamine Social Behavior Response To Cocaine Dopamine Metabolic Process Regulation Of Potassium Ion Transport Response To Morphine Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Blood Pressure Positive Regulation Of Mitotic Nuclear Division Acid Secretion Behavioral Response To Cocaine Negative Regulation Of Oligodendrocyte Differentiation Arachidonate Secretion Negative Regulation Of Protein Secretion Musculoskeletal Movement, Spinal Reflex Action Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Amine Transport Negative Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Secretion By Cell
Pathways		Recycling pathway of L1 Recycling pathway of L1 Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Dopamine receptors G alpha (i) signalling events
Drugs		1D-myo-inositol 1,4,5-trisphosphate	Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Sulpiride Loxapine Remoxipride Pramipexole Chlorpromazine Buspirone Haloperidol Amoxapine Lisuride Apomorphine Flupentixol Dopamine Ergoloid mesylate Pimozide Domperidone Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Iloperidone Rotigotine Norclozapine Cariprazine Mianserin Asenapine Amisulpride Sarizotan Sumanirole Nandrolone decanoate Captodiame AS-8112 Blonanserin Pipamperone Tianeptine Dihydro-alpha-ergocryptine Epicriptine Pardoprunox Piribedil Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Cognitive function ( 24684796) Computer vision syndrome ( 33941792) Coronary artery disease ( 32469254) Multiple sclerosis ( 31604244)	Chronotype ( 30696823) Feeling hurt ( 29500382) Personality dimensions ( 23903073) Smooth-surface caries ( 24556642)
Interacting Genes		23 interacting genes: ABCC2 ARHGDIA C1QTNF9 CALM1 CPNE1 CPNE2 CPNE4 DRD3 EZR FTCD GNA13 ICAM2 ITGB2 L1CAM LINC01554 NHERF1 NHERF2 PRPF38A PSME3 RBPMS ROCK1 TSC1 VPS11	16 interacting genes: CLIC6 DRD1 EEF1B2 EEF1G EPB41 EPB41L1 EPB41L2 FLNA GIPC1 GNAI1 GRB2 MPDZ NCK1 NCS1 RDX RGS9
Entrez ID		5962	1814
HPRD ID		01534	00540
Ensembl ID		ENSG00000137710	ENSG00000151577
Uniprot IDs		B0YJ88 P35241 Q6PKD3	A1A4V4 A8K8E4 E9PCM4 P35462 X5D2G4
PDB IDs			3PBL 7CMU 7CMV 8IRT 9F33 9F34
Enriched GO Terms of Interacting Partners?		Type 2 Metabotropic Glutamate Receptor Binding Membrane Docking Type 3 Metabotropic Glutamate Receptor Binding Membrane To Membrane Docking Response To Calcium Ion Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Cell Shape Leukocyte Cell-cell Adhesion Protein Localization To Membrane Microvillus Organization Positive Regulation Of Early Endosome To Late Endosome Transport Microvillus Assembly Calcium-dependent Phospholipid Binding Plasma Membrane Response To Metal Ion Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Rho Protein Signal Transduction Microvillus Receptor Internalization Uropod Protein Localization To Plasma Membrane Cellular Response To Calcium Ion Regulation Of Intracellular Signal Transduction Establishment Of Epithelial Cell Apical/basal Polarity Protein Localization To Cell Periphery Regulation Of Early Endosome To Late Endosome Transport Focal Adhesion Extracellular Exosome Associative Learning Cell Periphery Regulation Of Cell Morphogenesis G Protein-coupled Dopamine Receptor Signaling Pathway Cell-matrix Adhesion Ruffle Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Negative Regulation Of Intracellular Signal Transduction Cell-cell Adhesion Acid Secretion Microvillus Membrane Gland Morphogenesis Establishment Of Epithelial Cell Polarity Localization Within Membrane Positive Regulation Of Focal Adhesion Assembly Cortical Actin Cytoskeleton Organization Monocarboxylic Acid Transport Regulation Of Vesicle-mediated Transport Protein-membrane Adaptor Activity	Cell Cortex Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Protein Localization To Cell Cortex Cytoskeletal Protein Binding G Protein-coupled Dopamine Receptor Signaling Pathway Actin Binding D2 Dopamine Receptor Binding Cortical Actin Cytoskeleton Organization Positive Regulation Of Protein Localization Vesicle Membrane Presynaptic Modulation Of Chemical Synaptic Transmission Cortical Cytoskeleton Organization Regulation Of Cytoskeleton Organization Cadherin Binding Plasma Membrane Actin Cytoskeleton Organization Actin Filament-based Process Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Neuron Migration Cytoplasm Translation Elongation Factor Activity Regulation Of Actin Filament Organization Actomyosin Structure Organization Glutamatergic Synapse Regulation Of Protein Localization Negative Regulation Of Protein Catabolic Process Regulation Of Actin Filament Polymerization Spectrin Binding Cortical Cytoskeleton Ephrin Receptor Binding Positive Regulation Of Intracellular Transport Regulation Of Metal Ion Transport Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Response To Amphetamine Regulation Of Actin Filament Length Positive Regulation Of Potassium Ion Transport Regulation Of Protein Localization To Cell Periphery COP9 Signalosome Regulation Of Protein Catabolic Process Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Transport Regulation Of Monoatomic Ion Transport Extracellular Exosome Structural Molecule Activity Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Dendritic Shaft Positive Regulation Of Cytoskeleton Organization
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