NHERF1 and SLC22A4

Number of citations of the paper that reports this interaction (PubMedID 15553237)
0

Data Source:
HPRD (two hybrid)

		NHERF1	SLC22A4
Description		NHERF family PDZ scaffold protein 1	solute carrier family 22 member 4
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Stereocilium Tip Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece Plasma Membrane Protein Complex	Mitochondrion Plasma Membrane Basal Plasma Membrane Membrane Apical Plasma Membrane Mitochondrial Membrane Neuronal Cell Body
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Dopamine Receptor Binding Molecular Adaptor Activity Growth Factor Receptor Binding Channel Activator Activity	Nucleotide Binding Acetylcholine Transmembrane Transporter Activity Protein Binding ATP Binding Secondary Active Organic Cation Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Amino-acid Betaine Transmembrane Transporter Activity Carnitine Transmembrane Transporter Activity Symporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Transmembrane Transporter Activity PDZ Domain Binding
	Biological Process	Morphogenesis Of An Epithelium Renal Sodium Ion Transport Sodium Ion Transport Plasma Membrane Organization Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Fibroblast Migration Negative Regulation Of Fibroblast Migration Negative Regulation Of Sodium Ion Transport Wnt Signaling Pathway Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Intracellular Phosphate Ion Homeostasis Bile Acid Secretion Glutathione Transport Cilium Organization Establishment Of Epithelial Cell Apical/basal Polarity Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Localization In Cell Establishment Of Golgi Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Gamma-aminobutyric Acid Import Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cerebrospinal Fluid Circulation Renal Phosphate Ion Absorption Import Across Plasma Membrane Transport Across Blood-brain Barrier Regulation Of Renal Phosphate Excretion Negative Regulation Of Cell Motility Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Sulfur Amino Acid Transport Triglyceride Metabolic Process Monoatomic Ion Transport Sodium Ion Transport Neurotransmitter Transport Lactation Carnitine Metabolic Process Quaternary Ammonium Group Transport Carnitine Transport Response To Lipopolysaccharide Response To Vitamin D Xenobiotic Transport Response To Exogenous DsRNA Acetylcholine Uptake Transmembrane Transport Amino Acid Import Across Plasma Membrane Liver Regeneration Carnitine Transmembrane Transport
Pathways			SLC-mediated transport of organic cations
Drugs			Levocarnitine
Diseases		Nephrolithiasis/osteoporosis, hypophosphatemic	Crohn's disease
GWAS			Asthma ( 31619474) Asthma (sex interaction) ( 24824216) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 21102463 22412388 28067908) Estimated glomerular filtration rate ( 31152163) Fibrinogen ( 20031577) Fibrinogen levels ( 26561523) Granulocyte count ( 27863252) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Intracranial aneurysm ( 33199917) Itch intensity from mosquito bite ( 28199695) Lymphocyte count ( 32888494) Mean platelet volume ( 27863252) Metabolic traits ( 21886157) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Myocardial infarction ( 33532862) Nasal polyps ( 30643255) Neutrophil count ( 27863252) Platelet count ( 32888494) Serum metabolite levels ( 23093944 33031748) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 28067908) Urinary albumin-to-creatinine ratio ( 31511532) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 27863252)
Interacting Genes		67 interacting genes: ABCC2 ABCC4 ACE2 ADRB2 AKAP10 AKT1 APPBP2 ATP6V1B1 ATP6V1E1 BCL10 BCL2A1 BRSK2 CDK1 CEBPA CFTR CLCN3 CNGA2 CRABP1 CTNNB1 DLGAP4 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OGT OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PHLPP1 PIN1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC13A1 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 UBE3A YAP1 YES1 ZNF468	4 interacting genes: NHERF1 NHERF2 NHERF4 PDZK1
Entrez ID		9368	6583
HPRD ID		05406	09171
Ensembl ID		ENSG00000109062	ENSG00000197208
Uniprot IDs		O14745	Q9H015
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H 6RQR
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane Plasma Membrane Monoatomic Ion Transport Transmembrane Transport Basolateral Plasma Membrane Regulation Of Biological Quality Membrane Sodium Ion Transport Organic Anion Transport Monoatomic Ion Transmembrane Transport PDZ Domain Binding System Process Monoatomic Cation Transport Metal Ion Transport Cellular Response To Oxygen-containing Compound Inorganic Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Homeostasis Regulation Of MAPK Cascade Homeostatic Process Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of Transport Response To Lipid Inorganic Cation Transmembrane Transport Regulation Of Protein Localization Intracellular Chemical Homeostasis Monoatomic Cation Transmembrane Transport Regulation Of PH Organic Anion Transmembrane Transporter Activity Microvillus Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Early Endosome Sodium-independent Organic Anion Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Monocarboxylic Acid Transport Chemical Homeostasis Enzyme Binding Regulation Of Signaling Regulation Of Cell Communication Intracellular Monoatomic Cation Homeostasis Solute:inorganic Anion Antiporter Activity Positive Regulation Of Protein Localization To Endosome Inorganic Anion Transport Monoatomic Anion Transport Intracellular Monoatomic Ion Homeostasis	Protein-membrane Adaptor Activity Protein Localization To Plasma Membrane Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Cell Periphery Type 3 Metabotropic Glutamate Receptor Binding Protein Localization To Membrane Apical Plasma Membrane Signaling Receptor Binding Localization Within Membrane Microvillus Membrane Brush Border Membrane Phosphatase Binding Brush Border PDZ Domain Binding Cellular Localization Apical Part Of Cell Renal Phosphate Ion Absorption Guanylate Cyclase Inhibitor Activity Beta-catenin Binding Intracellular Protein Localization Susceptibility To T Cell Mediated Cytotoxicity Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Susceptibility To Natural Killer Cell Mediated Cytotoxicity Scavenger Receptor Binding Molecular Adaptor Activity Plasma Membrane Carnitine Transmembrane Transport Carnitine Transport Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Negative Regulation Of CGMP-mediated Signaling Endomembrane System Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Intracellular Phosphate Ion Homeostasis Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Transporter Activator Activity Glutathione Transport
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